Stimulation of renal phosphate secretion in the stenohaline freshwater teleost: Carassius auratus gibelio bloch

Kaune, R.; Hentschel, H.

doi:10.1016/0300-9629(87)90136-8

Cited by 15 publications

(5 citation statements)

References 9 publications

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“…Therefore, these animals must have the possibility to excrete excess phosphate by an additional tubular mechanism. This is corroborated by the observation of a significant secretion of serum phosphate by renal tubules in carp (26) and in the avian kidney (1). We have obtained evidence of glomerular intermittency of glomerular blood perfusion and/or filtration in conscious carp (15a).…”

Section: Functional Considerations Of Phosphate Excretion As Related To Glomerular Filtrationsupporting

confidence: 71%

“…39). Moreover, it was shown that freshwater carp respond to an intravenous infusion of P i by a considerable increase in tubular secretion of phosphate (26). Studies using micropuncture in elasmobranch fish (43), transport by isolated tubules (7), or cell culture (17) of teleost kidney tubules indicated that the proximal tubule is the site of net phosphate secretion.…”

mentioning

confidence: 99%

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Na-P_i cotransport sites in proximal tubule and collecting tubule of winter flounder (Pleuronectes americanus)

Elger

Werner

Herter

et al. 1998

American Journal of Physiology-Renal Physiology

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Localization of a recently described and cloned Na-Pi cotransport system from flounder was investigated by reverse transcription-polymerase chain reaction (RT-PCR) of microdissected tubules and by immunocytochemistry of kidney of winter flounder. Histological examination showed a small glomerulus, an extremely short proximal tubule PI with a selective affinity to Lens culinaris agglutinin from lentils, and an extensive second proximal tubule segment PII (>90% of proximal tubules), consisting of cells with numerous apical clear vesicles and extensive amplification of basolateral cell membranes. PII merged with the collecting tubule/collecting duct (CT/CD) system without a distal segment. By RT-PCR, PII cells revealed high levels of NaPi-II related RNA; low levels were also observed in CTs. Previously characterized antisera against different epitopes of flounder NaPi-II specifically labeled the basolateral regions of PII and the apical cell portion of CT/CD cells and of some PII cells. These results suggest that tubular secretion of Pi occurs in PII of teleost fish with modulation of urinary Picontent in the subsequent CT/CD system.

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Section: Functional Considerations Of Phosphate Excretion As Related To Glomerular Filtrationsupporting

confidence: 71%

mentioning

confidence: 99%

Na-P_i cotransport sites in proximal tubule and collecting tubule of winter flounder (Pleuronectes americanus)

Elger

Werner

Herter

et al. 1998

American Journal of Physiology-Renal Physiology

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“…DPW are excreted mostly as phosphate via the urine (Kaune & Hentschel 1987; Renfro 1997; Vielma & Lall 1998; Bureau & Cho 1999). In mammals, urinary phosphate excretion is determined mostly by plasma phosphate concentration (Bijvoet 1980).…”

Section: Reducing P Wastementioning

confidence: 99%

A review of diet formulation strategies and feeding systems to reduce excretory and feed wastes in aquaculture

Cho

Bureau

2001

Aquaculture Research

179

159

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Signi®cant efforts should be devoted to reducing waste outputs from aquaculture operations in order to lower the environmental impacts of aquaculture in many parts of the world. Since most aquaculture wastes are ultimately from dietary origin, reduction of waste outputs should ®rst be through improvements of diet formulation and feeding strategies. The ®rst step in the production of feeds producing less solid waste is to eliminate poorly digestible ingredients (such as whole grain or grain byproducts used as binders and ®llers in the feed formulae) and to use highly digestible ingredients with good binding properties. Further reduction of solid waste can then be achieved through careful selection of the ingredients to improve apparent digestibility and the nutrient balance of the feed. Nitrogen waste outputs can be reduced through the reduction of the digestible protein to digestible energy (DP/DE) ratio of the diet. Phosphorus waste outputs can be reduced through careful selection of the ingredients and optimization of the digestible phosphorus content of the diet to meet the requirement of the ®sh but avoid greatly exceeding this required level. Finally, feeding practices that minimize feed wastage should be adopted since feed wastage can have a very signi®cant impact on waste outputs from ®sh culture operations.

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“…However, under normal circumstances, the absolute concentration of phosphate in the urine is generally comparable that of ammonia on a molar basis ( Curtis and Wood, 1991 ; Curtis and Wood, 1992 ; Lawrence et al, 2015 ). In goldfish injected with exogenous phosphate, Kaune and Hentschel (1987) reported that 65% of the phosphate load was excreted by the kidneys, largely by secretion into the urine. As noted earlier, the urinary excretion rates of both phosphate and ammonia increase markedly during the compensation of respiratory and metabolic acidosis, in accord with the roles of these molecules as key urinary buffers in fish ( McDonald and Wood, 1981 ; Wheatly et al, 1984 ; Perry et al, 1987 ; Wood et al, 1999 ; Lawrence et al, 2015 ), just as in mammals ( Hills, 1973 ; Pitts, 1974 ).…”

Section: Excretion Of Ammonia and Phosphate By The Kidneysmentioning

confidence: 99%

Role of the kidneys in acid-base regulation and ammonia excretion in freshwater and seawater fish: implications for nephrocalcinosis

et al. 2023

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Maintaining normal pH levels in the body fluids is essential for homeostasis and represents one of the most tightly regulated physiological processes among vertebrates. Fish are generally ammoniotelic and inhabit diverse aquatic environments that present many respiratory, acidifying, alkalinizing, ionic and osmotic stressors to which they are able to adapt. They have evolved flexible strategies for the regulation of acid-base equivalents (H+, NH4+, OH− and HCO3−), ammonia and phosphate to cope with these stressors. The gills are the main regulatory organ, while the kidneys play an important, often overlooked accessory role in acid-base regulation. Here we outline the kidneys role in regulation of acid-base equivalents and two of the key ‘urinary buffers’, ammonia and phosphate, by integrating known aspects of renal physiology with recent advances in the molecular and cellular physiology of membrane transport systems in the teleost kidneys. The renal transporters (NHE3, NBC1, AE1, SLC26A6) and enzymes (V-type H+ATPase, CAc, CA IV, ammoniagenic enzymes) involved in H+ secretion, bicarbonate reabsorption, and the net excretion of acidic and basic equivalents, ammonia, and inorganic phosphate are addressed. The role of sodium-phosphate cotransporter (Slc34a2b) and rhesus (Rh) glycoproteins (ammonia channels) in conjunction with apical V-type H+ ATPase and NHE3 exchangers in these processes are also explored. Nephrocalcinosis is an inflammation-like disorder due to the precipitation of calcareous material in the kidneys, and is listed as one of the most prevalent pathologies in land-based production of salmonids in recirculating aquaculture systems. The causative links underlying the pathogenesis and etiology of nephrocalcinosis in teleosts is speculative at best, but acid-base perturbation is probably a central pathophysiological cause. Relevant risk factors associated with nephrocalcinosis are hypercapnia and hyperoxia in the culture water. These raise internal CO2 levels in the fish, triggering complex branchial and renal acid-base compensations which may promote formation of kidney stones. However, increased salt loads through the rearing water and the feed may increase the prevalence of nephrocalcinosis. An increased understanding of the kidneys role in acid-base and ion regulation and how this relates to renal diseases such as nephrocalcinosis will have applied relevance for the biologist and aquaculturist alike.

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Stimulation of renal phosphate secretion in the stenohaline freshwater teleost: Carassius auratus gibelio bloch

Cited by 15 publications

References 9 publications

Na-P_i cotransport sites in proximal tubule and collecting tubule of winter flounder (Pleuronectes americanus)

Na-P_i cotransport sites in proximal tubule and collecting tubule of winter flounder (Pleuronectes americanus)

A review of diet formulation strategies and feeding systems to reduce excretory and feed wastes in aquaculture

Role of the kidneys in acid-base regulation and ammonia excretion in freshwater and seawater fish: implications for nephrocalcinosis

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Stimulation of renal phosphate secretion in the stenohaline freshwater teleost: Carassius auratus gibelio bloch

Cited by 15 publications

References 9 publications

Na-Pi cotransport sites in proximal tubule and collecting tubule of winter flounder (Pleuronectes americanus)

Na-Pi cotransport sites in proximal tubule and collecting tubule of winter flounder (Pleuronectes americanus)

A review of diet formulation strategies and feeding systems to reduce excretory and feed wastes in aquaculture

Role of the kidneys in acid-base regulation and ammonia excretion in freshwater and seawater fish: implications for nephrocalcinosis

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Product

Resources

About

Na-P_i cotransport sites in proximal tubule and collecting tubule of winter flounder (Pleuronectes americanus)

Na-P_i cotransport sites in proximal tubule and collecting tubule of winter flounder (Pleuronectes americanus)