Abstract:Bovine aortic endothelial (BAE) cells contain two coexisting receptors for extracellular ATP [I], which have been designated the P2y and P2u purinoceptors. Agonist stimulation of these receptors leads to the release of the vasodilator substances prostacyclin (PGI2) and nitric oxide [2]. The aim of this study was to investigate the release of PG12 in BAE cells mediated by stimulation of these receptors.BAE cells were prepared from fresh bovine aortae by collagenase digestion essentially according to the method … Show more
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