Stimulation of Progesterone Release and Estrous Behavior by ACTH in Ovariectomized Rodents

Feder, Harvey H.; Ruf, K. B.

doi:10.1210/endo-84-1-171

Cited by 110 publications

(24 citation statements)

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“…In an attempt to test the suggested link between MAO activity and endocrine function an indirect assessment of progesterone production was made by measuring the progesterone content of the ovaries and the adrenal glands which can synthesize and secrete about equal amounts of progesterone in the rat (Feder & Ruf, 1969;Fajer et al, 1971).…”

Section: Discussionmentioning

confidence: 99%

The oestrous cycle and monoamine oxidase activity

Holzbauer

Youdim

1973

British J Pharmacology

127

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Summary1. During the oestrous cycle of the rat, monoamine oxidase (MAO) activity was studied in the uterus, the ovaries and the adrenal glands and also in 4 brain regions which are rich in monoamines. In all these structures the activity was lowest during the night between oestrus and metoestrus. High values were found in di-oestrus, with the exception of the uterus in which the MAO activity reached its peak during metoestrus. 2. A stimulating effect of progesterone on uterine, ovarian and adrenal MAO activity was observed.3. An index for the cyclic variations in progesterone production was obtained by measuring the adrenal and ovarian progesterone content at the same stages of the cycle as MAO activity. 4. The sum of the amounts of progesterone contained in the ovaries and adrenal glands was low in early oestrus but increased during late oestrus when MAO activity was at its minimum. Progesterone contents were high in metand di-oestrus when MAO activity was also high.

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Section: Discussionmentioning

confidence: 99%

The oestrous cycle and monoamine oxidase activity

Holzbauer

Youdim

1973

British J Pharmacology

127

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“…Risperidone had less marked effects (20-fold increases compared to vehicle at the highest dose tested) and haloperidol had minimal effects (2.7-fold increases compared to vehicle at the highest dose tested) on progesterone levels. While progesterone has been viewed most frequently in the context of ovarian secretion, adrenal synthesis appears to be functionally significant in rodents (Feder and Ruf, 1969;Walker et al, 2001) and may be relevant to nonreproductive functions in both males and females. For example, recent evidence suggests that progesterone actions contribute to central nervous system integrity.…”

Section: Olanzapine and Clozapine Effects On Serum Progesteronementioning

confidence: 99%

Olanzapine and Clozapine Increase the GABAergic Neuroactive Steroid Allopregnanolone in Rodents

Marx

VanDoren

Duncan

et al. 2003

Neuropsychopharmacol

132

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The neuroactive steroid allopregnanolone is a potent g-aminobutyric acid type A (GABA A ) receptor modulator with anxiolytic and anticonvulsant effects. Olanzapine and clozapine also have anxiolytic-like effects in behavioral models. We therefore postulated that olanzapine and clozapine would elevate allopregnanolone levels, but risperidone and haloperidol would have minimal effects. Male rats received intraperitoneal olanzapine (2.5-10.0 mg/kg), clozapine (5.0-20.0 mg/kg), risperidone (0.1-1.0 mg/kg), haloperidol (0.1-1.0 mg/ kg), or vehicle. Cerebral cortical allopregnanolone and peripheral progesterone and corticosterone levels were determined. Adrenalectomized animals were also examined. Both olanzapine and clozapine increased cerebral cortical allopregnanolone levels, but neither risperidone nor haloperidol had significant effects. Olanzapine and clozapine also increased serum progesterone and corticosterone levels. Adrenalectomy prevented olanzapine-and clozapine-induced elevations in allopregnanolone. Allopregnanolone induction may contribute to olanzapine and clozapine anxiolytic, antidepressant, and mood-stabilizing actions. Alterations in this neuroactive steroid may result in the modulation of GABAergic and dopaminergic neurotransmission, potentially contributing to antipsychotic efficacy.

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“…B. FAJER AND OTHERS Holzbauer, Newport, Birmingham & Traikov, 1969;. In the ovariectomized, oestrogen-primed rat and guinea-pig ACTH can stimulate the secretion of sufficient quantities of progesterone to facilitate female sexual receptivity (Feder & Ruf, 1969).…”

Section: Introductionmentioning

confidence: 99%