Stimulation of neuron‐like cell growth by Aloe substances

Bouthet, C.; Schirf, Virgil; Winters, Wendell D.

doi:10.1002/ptr.2650090306

Cited by 10 publications

(9 citation statements)

References 25 publications

(23 reference statements)

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“…Similarities between these presently described glycoprotein lectins and other lectins known to be glycoproteins from other Aloe species have been described (Winters et al, 1981;Winters, 1990;Winters, 1991;Winters, 1993;Imananishi, 1993;Saito, 1993;Suzuki et al, 1979). Yagi and coworkers (1985Yagi and coworkers ( , 1986Yagi and coworkers ( , 1987 (Bouthet and Winters, 1995).…”

Section: Discussionsupporting

confidence: 55%

“…Most recently, other investigators also described an Aloe fraction within the range of 5000-50 OOO MI with very active abilities to suppress ulcer formation and to heal induced ulcers in two in uiuo ulcer models (Teradaira et al, 1993). Our present results showed that 79% of peptides from young and 82% of peptides from mature plant whole leaf and leaf gel extracts are within the 5000 to 50 000 M I range and extracts containing these peptides have been shown to induce major bioactivities in haemagglutination and mitogenicity assays (Winters, 1990, 1991, 1993and Bouthet and Winters, 1995.…”

Section: Discussionmentioning

confidence: 62%

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Polypeptides of Aloe barbadensis miller

Winters

Bouthet

1995

Phytotherapy Research

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Major polypeptide species of proteins have been identified and analysed by sodium dodecyl sulphate polyacrylamide gel electrophoresis in fresh extracts of the whole leaf, leaf gel, root and stalk portions of Aloe barbudensis Miller plants of immature, young and mature ages. Extracts of the fresh Aloe plant portions were prepared by dissection, tissue disruption, differential centrifugation and gel filtration methods. Extracted plant portions analysed by separation electrophoresis were also assayed by biochemical and immunological techniques for the presence of lectin associated reactions, i.e. agglutination or mitogenicity. Results of the separation electrophoresis analysis of extracts prepared from fresh whole leaves and leaf gel of mature Aloe barbadensis Miller plants revealed 23 identifiable difterent polypeptides. Molecular weights of these polypeptides, calculated from sets of molecular weight reference standards, ranged from 70000 for the largest to 3OOO for the smallest. Electrophoresis profiles of commercially processed and freshly processed Aloe barbadensis Miller and Aloe suponaria Haw leaf gel extracts revealed similar patterns for major peptides. Treatment of mature whole Aloe leaf extracts with acidic and alkaline conditions revealed distinct changes in pH stability of ten peptides. Comparisons of separation electrophoresis profiles of fresh extracts of Aloe whole leaves and of leaf gel portions revealed marked differences in both molecular weights and concentrations of peptides found in extracts from mature, young or immature plants. This report is the first to describe the nature and types of polypeptides detected in extracts of whole leaf, leaf gel, stalk and root portions of immature, young and mature Aloe plants. Accordingly, information in this report may be of considerable value in helping to identify and characterize Aloe substances present during processing in extracts and in products.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 62%

Polypeptides of Aloe barbadensis miller

Winters

Bouthet

1995

Phytotherapy Research

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“…There is some evidence in literature on the effect of A. vera on neuronal activity. Bouthet and coworkers have demonstrated that A. vera increases proliferation in cultured ‘neuron‐like’ rat adrenal pheochromocytoma cells treated in suspension . Another study provides evidence of direct concentration‐dependent depressive effect of A. vera on the neurotransmission process with respect to presynaptic and postsynaptic mechanisms .…”

Section: Introductionmentioning

confidence: 96%

“…Bouthet and coworkers have demonstrated that A. vera increases proliferation in cultured 'neuron-like' rat adrenal pheochromo-cytoma cells treated in suspension. [11] Another study provides evidence of direct concentration-dependent depressive effect of A. vera on the neurotransmission process with respect to presynaptic and postsynaptic mechanisms. [12] Moreover, a recent study has reported that A. vera improves anti-oxidant activity within the hippocampus and cerebral cortex leading to improvement of motor and memory behavioural tasks in diabetic mice.…”

Section: Introductionmentioning

confidence: 98%

Anticonvulsant activity of Aloe vera leaf extract in acute and chronic models of epilepsy in mice

Rathor

Arora

Manocha

et al. 2013

Journal of Pharmacy and Pharmacology

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“…2 Bouthet and co-workers have demonstrated that A. vera increases proliferation in cultured 'neuron-like' rat adrenal pheochromocytoma cells treated in suspension. 8 Another study provides evidence of direct concentration-dependent depressive effect of A. vera on the neurotransmission process with respect to preand post-synaptic mechanisms. 2 Moreover, a recent study has reported that A. vera improves antioxidant activity within the hippocampus and cerebral cortex leading to improvement of the motor and memory behavioural tasks in diabetic mice.…”

Section: Introductionmentioning

confidence: 98%