Stimulation of lateral hypothalamic kainate receptors selectively elicits feeding behavior

Hettes, Stacey R.; Heyming, Theodore; Stanley, B. Glenn

doi:10.1016/j.brainres.2007.09.060

Cited by 13 publications

(3 citation statements)

References 45 publications

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“…For example, Leibowitz (1975) used a protocol (Wolf and Yen, 1968) modified from the original method of Klüver and Barrera (1953) to visualize anterior lateral hypothalamic sites where amphetamine suppresses feeding in rats, by labeling cells (using a Nissl stain) and myelin sheaths (using Luxol Fast Blue) in the same tissue (Figure 1H). Finally, extending work done by the Stanley laboratory establishing a role for glutamate and its receptor agonists in feeding control through actions within the lateral hypothalamic area (Stanley et al, 1993a,b,c, 1996; Khan et al, 1999, 2004; Duva et al, 2001, 2002, 2005; Hettes et al, 2003, 2007, 2010; see Stanley et al, 2011), Li et al (2011) have carefully delineated the locations of feeding-sensitive sites for the glutamate receptor agonists NMDA and AMPA by using rigorous methods for situating the locations of their hypothalamic injections that triggered feeding behavior (Figure 1S). …”

Section: The Experimental Control Of Food Intake Using Ici: a Briementioning

confidence: 78%

Controlling feeding behavior by chemical or gene-directed targeting in the brain: what's so spatial about our methods?

Khan

2013

Front. Neurosci.

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Intracranial chemical injection (ICI) methods have been used to identify the locations in the brain where feeding behavior can be controlled acutely. Scientists conducting ICI studies often document their injection site locations, thereby leaving kernels of valuable location data for others to use to further characterize feeding control circuits. Unfortunately, this rich dataset has not yet been formally contextualized with other published neuroanatomical data. In particular, axonal tracing studies have delineated several neural circuits originating in the same areas where ICI injection feeding-control sites have been documented, but it remains unclear whether these circuits participate in feeding control. Comparing injection sites with other types of location data would require careful anatomical registration between the datasets. Here, a conceptual framework is presented for how such anatomical registration efforts can be performed. For example, by using a simple atlas alignment tool, a hypothalamic locus sensitive to the orexigenic effects of neuropeptide Y (NPY) can be aligned accurately with the locations of neurons labeled by anterograde tracers or those known to express NPY receptors or feeding-related peptides. This approach can also be applied to those intracranial “gene-directed” injection (IGI) methods (e.g., site-specific recombinase methods, RNA expression or interference, optogenetics, and pharmacosynthetics) that involve viral injections to targeted neuronal populations. Spatial alignment efforts can be accelerated if location data from ICI/IGI methods are mapped to stereotaxic brain atlases to allow powerful neuroinformatics tools to overlay different types of data in the same reference space. Atlas-based mapping will be critical for community-based sharing of location data for feeding control circuits, and will accelerate our understanding of structure-function relationships in the brain for mammalian models of obesity and metabolic disorders.

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Section: The Experimental Control Of Food Intake Using Ici: a Briementioning

confidence: 78%

Controlling feeding behavior by chemical or gene-directed targeting in the brain: what's so spatial about our methods?

Khan

2013

Front. Neurosci.

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“…These effects on leptin and insulin signalling ultimately lead to an increase in the transcription of genes encoding for anorectic peptides including POMC, thyrotropin‐releasing hormone (TRH), and corticotropin‐releasing hormone (CRH) . Topiramate‐induced AMPA receptor inhibition could also have a role in the anorectic activity of this drug considering that the stimulation of hypothalamic AMPA receptors induces feeding in rats . The evidence that oestrogens control hypothalamic AMPA receptor expression suggests that topiramate anorectic efficacy could be different between men and women.…”

Section: Phentermine/topiramate Combinationmentioning

confidence: 99%

Gender‐related issues in the pharmacology of new anti‐obesity drugs

et al. 2018

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Four new medicines-liraglutide, lorcaserin, bupropion/naltrexone, and phentermine/ topiramate-have been recently added to the pharmacological arsenal for obesity treatment and could represent important tools to manage this epidemic disease. To achieve satisfactory anti-obesity goals, the use of these new medicines should be optimized and tailored to specific patient subpopulations also by applying dose adjustments if needed. In the present review, we posit that gender could be among the factors influencing the activity of the new obesity drugs both because of pharmacokinetic and pharmacodynamic factors. Although evidence from premarketing clinical studies suggested that no dose adjustment by gender is necessary for any of these new medicines, these studies were not specifically designed to identify genderrelated differences. This observation, together with the strong theoretical background supporting the hypothesis of a gender-dimorphic response, strongly call upon an urgent need of new real-life data on gender-related difference in the pharmacology of these new obesity drugs.

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“…Blocking excitatory glutamatergic input into the nucleus accumbens shell with the AMPA and kainate receptor antagonist DNQX stimulates food intake (Kelley and Swanson, 1997; Maldonadoirizarry et al, 1995). Within the lateral hypothalamus, ionotropic glutamate receptors appear to stimulate feeding, as injections of AMPA, NMDA or kainate into the lateral hypothalamus induce feeding (Stanley et al, 1993), and inhibiting these receptors suppresses feeding (Hettes et al, 2007; Hettes et al, 2010; Urstadt et al, 2013). Within the hindbrain, AMPA/KA receptors and NMDA receptors have opposing effects on feeding behavior.…”

Section: Introductionmentioning

confidence: 99%

NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract

Vance¹,

Rogers²,

Hermann³

2015

Brain Research

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Previous behavioral studies have demonstrated that presynaptic N-methyl-D-aspartate (NMDA) receptors expressed on vagal afferent terminals are involved in food intake and satiety. Therefore, using in vitro live cell calcium imaging of prelabeled rat hindbrain slices, we characterized which NMDA receptor GluN2 subunits may regulate vagal afferent activity. The nonselective NMDA receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (D,L-AP5) significantly inhibited vagal terminal calcium influx, while the excitatory amino acid reuptake inhibitor D,L-threo-β-benzyloxyaspartic acid (TBOA), significantly increased terminal calcium levels following pharmacological stimulation with ATP. Subunit-specific NMDA receptor antagonists and potentiators were used to identify which GluN2 subunits mediate the NMDA receptor response on the vagal afferent terminals. The GluN2B-selective antagonist, ifenprodil, selectively reduced vagal calcium influx with stimulation compared to the time control. The GluN2A-selective antagonist, 3-chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino] carbonyl] benzyl]benzenesulfonamide (TCN 201)produced smaller but not statistically significant effects. Furthermore, the GluN2A/B-selective potentiator (pregnenolone sulfate) and the GluN2C/D-selective potentiator [(3-chlorophenyl)(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-3,4-dihydroisoquinolin-2(1 H)-yl)methanone; (CIQ)] enhanced vagal afferent calcium influx during stimulation. These data suggest that presynaptic NMDA receptors with GluN2B, GluN2C, and GluN2D subunits may predominantly control vagal afferent excitability in the nucleus of the solitary tract.

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Stimulation of lateral hypothalamic kainate receptors selectively elicits feeding behavior

Cited by 13 publications

References 45 publications

Controlling feeding behavior by chemical or gene-directed targeting in the brain: what's so spatial about our methods?

Controlling feeding behavior by chemical or gene-directed targeting in the brain: what's so spatial about our methods?

Gender‐related issues in the pharmacology of new anti‐obesity drugs

NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract

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