Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors

Heringdorf, Dagmar Meyer zu; Lass, Holger; Kuchar, Igor; Lipinski, Mathias; Alemany, Regina; Rümenapp, Ulrich; Jakobs, Karl H.

doi:10.1016/s0014-2999(01)00789-0

Cited by 92 publications

(58 citation statements)

References 35 publications

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“…EDG-1 receptors have previously been shown to dominate in endothelial cells and to be expressed in lower amounts in epithelial, neural, and myocytic cells, whereas EDG-3 and EDG-5 are widely expressed in epithelial cells and fibroblasts, although EDG-3 is also found in brain neuronal cells (26). EDG-1, -3, and -5 are also expressed in HEK-293 cells (27). EDG-6 is an orphan that has been isolated from dendritic cells and lymphoid and hematopoietic tissue and lung (26,28).…”

Section: Discussionmentioning

confidence: 99%

Endothelial Differentiation Gene Receptors in Pancreatic Islets and INS-1 Cells

2003

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The endothelial differentiation gene (EDG) receptors are a class of G protein-coupled receptors. EDG-1, -3, -5, -6, and -8 bind the bioactive lipid sphingosine-1-phosphate (SPP) as the primary signaling ligand. EDG-2, -4, and -7 bind the ligand lysophosphatidic acid. EDG-1, -2, -3, -5, -6, and -7, but not -8, mRNAs were expressed in isolated rat pancreatic islets, whereas INS-1 insulinoma cells expressed only EDG-1, -2, -3, and -5 mRNAs. EDG-4 mRNA was expressed in mouse islets. EDG-1 mRNA but not EDG-3 mRNA was rapidly induced relative to 18S rRNA after stimulation of isolated islets with phorbol 12-myristate 13-acetate (PMA) or cholecystokinin-8S for 2 h. The protein kinase C inhibitor GF 109203X blocked the EDG-1 induction by PMA. Similarly, in islets stimulated for 2 h with 17 mmol/l glucose, the relative EDG-1 mRNA levels increased almost twofold compared with levels in control islets at 5.5 mmol/l glucose. In contrast, after 11 mmol/l glucose stimulation for 7 days, the relative levels of rat islet EDG-1 mRNA were significantly reduced to 54% below that of islets cultured at 5.5 mmol/l glucose. There was no change in relative EDG-3 mRNA levels. Stimulation of EDG receptors in islets and INS-1 cells with SPP inhibited glucagon-like peptide 1 (GLP-1)-stimulated cAMP production and insulin secretion in a concentration-dependent manner. Pertussis toxin antagonized the SPP effects on insulin release. Thus, EDG receptors are expressed in pancreatic islet ␤-cells and G i seems to mediate the inhibition by SPP of adenylyl cyclase and cAMP formation and inhibition of the stimulation of insulin secretion by GLP-1. Diabetes

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Section: Discussionmentioning

confidence: 99%

Endothelial Differentiation Gene Receptors in Pancreatic Islets and INS-1 Cells

2003

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“…Sphingosine kinase is activated by numerous external stimuli including PDGF (45), nerve growth factor (59), muscarinic acetylcholine agonists (31), cytokines such as tumor necrosis factor-␣ (38) and interleukin-1␤ (60), vitamin D3 (61), and cross-linking of the immunoglobulin receptors Fc⑀RI (62) and Fc␥RI (63) and GPCRs, including S1PRs themselves (64). Overexpression of SPHK1 in NIH 3T3 fibroblasts resulted in enhanced proliferation (48), growth in soft agar, and tumor formation in NOD/SCID mice (65).…”

Section: Metabolism Of Sphingosine 1-phosphatementioning

confidence: 99%

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

Spiegel

Milstien²

2002

Journal of Biological Chemistry

518

473

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“…The recently reported CKI1, receptor of cytokinin in Arabidopsis, was a histidine kinase. Sphingosine kinase, together with phospholipase C, phospholipae D and MAPK, were involved in the cell response to environmental stimuli including growth factors, cytokinin, G-protein coupled stimulator and so on [40], [42][43][44]. Up-regulation of rice histidine kinase and sphingosine kinase by ABA treatment may suggest their roles in ABA function.…”

Section: Possible Aba Related Signaling Pathwaysmentioning

confidence: 99%

“…Histidine kinase plays a role in many signal transduction pathways [38][39][40] Histidine kinase domain was found in phytochrome and related to rhymes [41]. The recently reported CKI1, receptor of cytokinin in Arabidopsis, was a histidine kinase.…”

Section: Possible Aba Related Signaling Pathwaysmentioning

confidence: 99%

Identification of ABA-responsive genes in rice shoots via cDNA macroarray

Lin

et al. 2003

Cell Res

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Phytohormone abscisic acid (ABA) was critical for many plant growth and developmental processes including seed maturation, germination and response to environmental factors. With the purpose to detect the possible ABA related signal transduction pathways, we tried to isolate ABA-regulated genes through cDNA macroarray technology using ABA-treated rice seedling as materials (under treatment for 2, 4, 8 and 12 h). Of 6144 cDNA clones tested, 37 differential clones showing induction or suppression for at least one time, were isolated. Of them 30 and 7 were up-or down-regulated respectively. Sequence analyses revealed that the putative encoded proteins were involved in different possible processes, including transcription, metabolism and resistance, photosynthesis, signal transduction, and seed maturation. 6 cDNA clones were found to encode proteins with unknown functions. Regulation by ABA of 7 selected clones relating to signal transduction or metabolism was confirmed by reverse transcription PCR. In addition, some clones were further shown to be regulated by other plant growth regulators including auxin and brassinosteroid, which, however, indicated the complicated interactions of plant hormones. Possible signal transduction pathways involved in ABA were discussed.

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Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors

Cited by 92 publications

References 35 publications

Endothelial Differentiation Gene Receptors in Pancreatic Islets and INS-1 Cells

Endothelial Differentiation Gene Receptors in Pancreatic Islets and INS-1 Cells

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

Identification of ABA-responsive genes in rice shoots via cDNA macroarray

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