Stimulation of Insulin Secretion by Guanidinoacetic Acid and Other Guanidine Derivatives<sup>1</sup>

Alsever, Robert N.; Georg, Ralph H.; Sussman, Karl E.

doi:10.1210/endo-86-2-332

Cited by 60 publications

(35 citation statements)

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“…Possibly, the mechanism through which creatine affects glucose metabolism is the stimulation of insulin pancreatic secretion, since, although glucose is the greatest stimulator of insulin secretion, it can also be induced by proteins and amino acids. The role of creatine as stimulator of insulin secretion has been demonstrated in in vitro (18)(19) as well as in vivo studies, confirming the very same alterations (16)(17) . Nevertheless, this long-term insulin hypersecretion may induce also to insulin resistance (20) , which has probably not been previously studied in creatine supplementation.…”

Section: Introductionsupporting

confidence: 57%

“…It has been demonstrated in vitro (18)(19) that creatine affects the metabolism of the carbohydrates when directly stimulates the insulin secretion of isolated pancreatic islets. Such fact was confirmed in vivo (16) in a work studying the creatine supplementation in rats in order to observe the long-term effects in the glucose transportation and storage in the skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

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Resistência à insulina com a suplementação de creatina em animais de experimentação

Costallat¹,

Miglioli²,

Silva³

et al. 2007

Rev Bras Med Esporte

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Introduction and objective:Creatine supplementation has been used in order to improve muscular performance. This substance affects glucose metabolism and stimulates the in vitro as well as the in vivo insulin secretion. Nevertheless, long-term insulin hypersecretion may also induce insulin resistance. The present work analyzed the effects of creatine oral supplementation in order to evaluate the possibility of occurrence of resistance to in vivo insulin. Methods: Forty-eight Wistar rats (24 female/ 24 male) were divided in two groups of 24 (control and study) and subdivided in six groups of eight. They were fed with standard food during four weeks, having water ad libitum. Moreover, the study group received dietetic supplement of creatine (0.4 g creatine for 30 ml of water per rat / day). In the 7 th , 14 th , 21 st and 28 th day of the experiment, 12 rats were anesthetized (sodium thiopental 0.15 mL/ 100 g) after six hour-fasting, being submitted to intravenous insulin tolerance test (0.5 mL of 30% regular human insulin and 70% saline solution). The blood samples were collected from the tail veins of the rats, in the basal, three, six, nine, 12 and 15 minutes after insulin administration times. The glucose measurement was performed through the glucose oxidase method. The study was previously approved by the Research Ethics Committee of CCMB-PUC-SP. Results: The mean of the glucose decrease constant (K ITT ) was calculated through the formula 0.693/ T 1/2 . The study group, when compared with the control group, presented insulin resistance at day 21 (p < 0.0004) and day 28 (p < 0.0001). Conclusion: This study shows that extended creatine supplementation may lead to insulin resistance. Besides that, it should be carefully used in individuals with glucose metabolism disturbances.

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Section: Introductionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Resistência à insulina com a suplementação de creatina em animais de experimentação

Costallat¹,

Miglioli²,

Silva³

et al. 2007

Rev Bras Med Esporte

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“…. r insulin secretion (4). However, the biological signmGuanidinoacetic acid is synthesized by glycine cance of guanidinoacetic acid in the body is most amidinotransferase 1 ) (transamidinase) mainly in the apparent when guanidinoacetic acid synthesis is dekidney (1).…”

Section: Ttmentioning

confidence: 99%

Biosynthesis of Guanidinoacetic Acid in Isolated Renal Tubules

Takeda¹,

Kiyatake²,

Koide³

et al. 1992

Clinical Chemistry and Laboratory Medicine

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Summary:Guanidinoacetic acid, a precursor of creatine, is an essential substrate for muscle energy metabolism. Since guanidinoacetic acid has been reported to be synthesized from arginine and glycine by glycine amidinotransferase (transamidinase) in kidney homogenates or slices, the purpose of this study was to provide evidence of guanidinoacetic acid synthesis in isolated tubules from rat kidneys, and to clarify the mechanism regulating it. Isolated rat tubules were incubated with various substrates. Guanidinoacetic acid was separated by high performance liquid chromatography and measured fluorometrically.Results obtained were as follows:(1) Guanidinoacetic acid was synthesized from arginine or canavanine and glycine in isolated rat tubules.(2) Z),Z,-Norvaline, ornithine and methionine suppressed guanidinoacetic acid synthesis.(3) Creatine suppressed guanidinoacetic acid synthesis, i.e. creatine was a negative feedback inhibitor of guanidinoacetic acid synthesis in this in vitro system.(4) Guanidinoacetic acid was not synthesized from hydroxyurea, citrulline, argininosuccinic acid or canaline.These data demonstrate that guanidinoacetic acid is synthesized only from arginine or canavanine and glycine, and that the guanidine cycle may not function fully in the rat renal tubule.

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“…Structure-function studies performed to investigate the betacytotropic effect of arginine, have suggested that the guanidino group may be involved in triggering insulin release, since several compounds that contain this radical within their molecule are capable of stimulating the secretion of insulin, both in vivo [l] and in vitro [2] .…”

Section: Introductionmentioning

confidence: 99%

Glucagon‐releasing activity of guanidine compounds in mouse pancreatic islets

et al. 1976

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Stimulation of Insulin Secretion by Guanidinoacetic Acid and Other Guanidine Derivatives¹

Cited by 60 publications

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Resistência à insulina com a suplementação de creatina em animais de experimentação

Resistência à insulina com a suplementação de creatina em animais de experimentação

Biosynthesis of Guanidinoacetic Acid in Isolated Renal Tubules

Glucagon‐releasing activity of guanidine compounds in mouse pancreatic islets

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Stimulation of Insulin Secretion by Guanidinoacetic Acid and Other Guanidine Derivatives1

Cited by 60 publications

References 0 publications

Resistência à insulina com a suplementação de creatina em animais de experimentação

Resistência à insulina com a suplementação de creatina em animais de experimentação

Biosynthesis of Guanidinoacetic Acid in Isolated Renal Tubules

Glucagon‐releasing activity of guanidine compounds in mouse pancreatic islets

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Stimulation of Insulin Secretion by Guanidinoacetic Acid and Other Guanidine Derivatives¹