Stimulation of Inflammatory Markers After Blunt Trauma

Giannoudis, P.V.; Smith, R. M.; Banks, Rosamonde E.; Windsor, Acj; Dickson, R. A.; Guillou, P. J.

doi:10.1097/00024382-199703001-00179

Cited by 18 publications

(19 citation statements)

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“…When interpreting the data it is important to recognize that high CD11b expression is not specific for infection-triggered inflammation and may, at least in adults, be induced by a variety of noninfectious conditions, such as trauma and autoimmune diseases (15)(16)(17)(21)(22)(23)(24)(25). In the present study, specificity and sensitivity of the CD11b test for sepsis were reasonably high in monocytes, but the specificity was quite poor in neutrophils.…”

Section: Discussionmentioning

confidence: 50%

Increased CD11b-Density on Circulating Phagocytes as an Early Sign of Late-Onset Sepsis in Extremely Low-Birth-Weight Infants

Turunen¹,

Andersson²,

Nupponen³

et al. 2005

Pediatr Res

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Section: Discussionmentioning

confidence: 50%

Increased CD11b-Density on Circulating Phagocytes as an Early Sign of Late-Onset Sepsis in Extremely Low-Birth-Weight Infants

Turunen¹,

Andersson²,

Nupponen³

et al. 2005

Pediatr Res

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“…2). This is due to similar disturbances of homeostasis in those two types of shock with excessive stimulation of the immune system leading in some cases to organ dysfunction or even multiple organ failure (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38).…”

Section: Resultsmentioning

confidence: 99%

“…This resulted from the fact that massive bleeding requires intensive fluid transfusions (3,14,23,(44)(45)(46)(47) and comprises the initial dominating disorder found in patients with multiple injuries. As a result of distinct inflammatory response found in both diseases, two patients suffering from acute pancreatitis were falsely classified into the MOC group, (27)(28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Models of Certain Types of Surgical Shock Based on the Assessment of Selected Critical Parameters

Budzyński

Brongel

Nazimek

et al. 2007

Polish Journal of Surgery

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The aim of the study was to devise models that describe three types of surgical shock based on a set of simple biochemical and clinical parameters and establish a method of assigning new patients to each surgical shock scenario. Material and methods. Prospective analysis included patients hospitalized in IInd Chair of Surgery from 2001 to 2005 who belonging to the following groups: multiple injuries (at least 7 points according to LSO), upper GI bleeding (in patients requiring blood transfusions during first day) and severe acute pancreatitis (at least 3 rd degree according to Trapnell's scale). A set of nineteen parameters was evaluated on the first, fourth and seventh day in every patient. Discrimination analysis was used for statistical analysis with calculation of Mahalanobis squared distances between groups that reflect their reciprocal differences. Discrimination functions were calculated allowing the assignment of a new observation to one of the models. Eventually, reliability of categorizing patients to the studied groups was evaluated. Results. Differences among the groups -reflected by Mahalanobis squared distances -proved statistically significant in every studied day. Overall, the ratio of proper classifications according to discrimination functions equaled about 87%. The most common mistake in categorizing was observed in groups of multiple injuries and acute pancreatitis -due to similar pathophysiological processes leading through SIRS to MOF. Conclusions. The abovementioned results indicate that the presented models can be successfully used in diagnostic processes, especially in emergency cases. The set of clinical and biochemical parameters used is simple and easy to obtain even in non-specialized centers. Key words: multiple injuries, acute pancreatitis, upper GI bleeding, discrimination analysis POLSKI PRZEGLĄD CHIRURGICZNY 10.2478/v10035-007-0054-2 2007 Significant effort was made to create a uniform system for the assessment of patient clinical status -regardless of the underlying disease, which would serve as a help for making therapeutic decisions and evaluating prognosis. For this purpose, many scales assessing the severity of homeostatic disturbances were created. In spite of their abundance, there is still a lack of single scale that can quickly, precisely and unequivocally set proper diagnosis in different life-threatening conditions. Moreover, many from the recently devised scales are based on parameters that require significant time or sophisticated techniques to obtain results (1-11). A system established to assess patient clinical status and aid in making proper diagnosis -especially in situations requiring immediate interventions -could improve the process of initial triage in Emergency Departments with limited access to highly specialized diagnostic techniques.The aim of this study was to create models of response in three commonly found settings of surgical and traumatological shock based on a set of selected critical parameters.

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“…IL-6 is one of the pro-inflammatory cytokines that is produced by various cells such as monocyte, macrophage, lymphocyte, fibroblast and endothelial cells. Giannoudis et al [29] have demonstrated that serum IL-6 concentration has an important role in tissue injury and in SIRS, and is significantly increased in patients with severe trauma. In one report, it has been found that in patients with a high Apache II and organ insufficiency score, IL-6 levels were significantly increased.…”

Section: Ast=aspartat Amino Transpherase Crp= C-reactive Protein Ilmentioning

confidence: 99%

The effects of immunosuppressive agents on inflammatory response in septic rats

Filiz

Öztürk²,

Kurt

et al. 2010

Open Medicine

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AbstractSepsis remains a serious clinical problems resulting in high morbidity and mortality. We aimed to investigate the inflammatory response in a septic rat model treated with immunomodulator agents. We used the cecal ligature and puncture model to establish septic peritonitis in rats. Male Wistar-Albino rats were randomized into groups of seven rats each and assigned different regimens: Tacrolimus 1 mg/kg/day, cyclosporin-A 5 mg/kg/day and methylprednisolone 15 mg/kg/day. These immunsuppressive agents were applied at the 6 and 48 hour intraperitoneally. The animals were euthanized after 6 and 48 hours and systemic parameters including, IL-2, IL-6, TNF-a, CRP, AST and creatinine were examined. Our study demonstrated that the experimental peritonitis model caused a meaningful rise in the values of systemic parameters. This was especially apparent for early-applied cyclosporin A; in addition, tacrolimus significantly decreased the levels both at the 6 and 48 hour. The excess immune response in complex sepsis treatment might be restrained using immunosuppressive agents administered early. Although additional supportive, comprehensive, experimental and clinical studies are still needed, this therapy model may prove to be an alternative for the future.

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Stimulation of Inflammatory Markers After Blunt Trauma

Cited by 18 publications

References 0 publications

Increased CD11b-Density on Circulating Phagocytes as an Early Sign of Late-Onset Sepsis in Extremely Low-Birth-Weight Infants

Increased CD11b-Density on Circulating Phagocytes as an Early Sign of Late-Onset Sepsis in Extremely Low-Birth-Weight Infants

Models of Certain Types of Surgical Shock Based on the Assessment of Selected Critical Parameters

The effects of immunosuppressive agents on inflammatory response in septic rats

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