Stimulation of Gastrin Release by Catecholamines

Hayes, J. R.; Kennedy, T. L.; Ardill, Joy; Shanks, R. G.; Buchanan, K. D.

doi:10.1016/s0140-6736(72)90802-1

Cited by 106 publications

(35 citation statements)

References 9 publications

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“…The finding of unchanged fasting serum gastrin levels following labetalol infusion is in agreement with some data obtained after administration of a- (Barbieri et al., 1980) and ,8-adrenoceptor blocking drugs in man, although reduced gastrin levels have also been reported by others (Hayes et al, 1972;Kronborg et al, 1974;Seino et al, 1980 …”

Section: Effect Of Labetalol An A-and 8-adrenoceptor Antagonist Onsupporting

confidence: 90%

Effect of labetalol, an alpha‐and beta‐adrenoceptor antagonist, on gastric acid and gastrin secretion in man.

Caldara¹,

Rampini²,

Piepoli³

et al. 1982

Brit J Clinical Pharma

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respectively. The mean percentage decrease in exercise heart rate produced by atenolol was 30 + 3 s.d. %.We conclude that, in a standard therapeutic dose, atenolol does not inhibit the metabolism of antipyrine in man. Taken together with our earlier observations concerning the inhibitory effects of propranolol and metoprolol this finding supports the proposed relationship between the lipid-solubility of ,Badrenoceptor blockers and their ability to inhibit oxidative drug metabolism.

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Section: Effect Of Labetalol An A-and 8-adrenoceptor Antagonist Onsupporting

confidence: 90%

Effect of labetalol, an alpha‐and beta‐adrenoceptor antagonist, on gastric acid and gastrin secretion in man.

Caldara¹,

Rampini²,

Piepoli³

et al. 1982

Brit J Clinical Pharma

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“…18 " 20 In the present study, all the patients with an increase in urinary adrenalin excretion did not show an elevation of serum gastrin concentration. However, with reference to this relationship, further investigation may be necessary.…”

Section: Acute Gastric Changes In Patients With Acute Stroke 2/kitamsupporting

confidence: 43%

Acute gastric changes in patients with acute stroke. Part 2: gastroendoscopic findings and biochemical observation of urinary noradrenalin, adrenalin, 17-OHCS and serum gastrin.

Kitamura¹,

K²

1976

Stroke

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SUMMARY To investigate the relationships between gastric change accompanying patients with acute stroke and the function of the autonomic nervous system and pituitary-adrenal system, studies on the gastroendoscopic technique and biochemical observations were done in 122 patients.The mean urinary noradrenalin and adrenalin excretions were elevated in patients with acute gastric changes, especially in patients with multiple erosions and acute ulcers.An elevation of the mean fasting serum gastrin concentration was found in patients with acute ulcers and no acute gastric changes.The mean urinary 17-OHCS excretion was increased in patients with multiple erosions, petechiae and acute ulcers.In conclusion, the sympathetic and parasympathetic nervous system and the pituitary-adrenal system have respectively different roles in the production of various types of acute gastric changes in patients.ACUTE CHANGES of the gastrointestinal tract in association with cerebral disease have been recognized since the first half of the nineteenth century. This subject has received much attention more recently, and a number of clinical and experimental studies on patients with various cerebral diseases and concomitant gastrointestinal changes have been reported.'"* These studies suggested that such gastrointestinal changes were induced by the accelerated function of the autonomic system and/or pituitary-adrenal system due to a lesion of the hypothalamus or its centrifugal tracts. But, in spite of considerable clinical and experimental work, the role of the autonomic nervous system and hypothalamicpituitary-adrenal system in the production of acute gastrointestinal changes still remains unclear.In the present study, in order to investigate the relationship between acute gastric change accompanying cases of acute stroke and the function of the autonomic nervous system and pituitary-adrenal system, studies using the gastroendoscopic technique, and analyses of urinary noradrenalin excretion, urinary adrenalin excretion, serum gastrin concentration and urinary 17-OHCS excretion were done on 122 patients with acute stroke. MethodsOne hundred twenty-two patients who were admitted to the Research Institute of Brain and Blood Vessels, Akita, Japan, from May 1973 to October 1974 were studied, including 50 with cerebral hemorrhage, 40 with cerebral infarction, and 32 with subarachnoid hemorrhage. In all patients positive results of these cerebral lesions were found by carotid and/or vertebral angiography, and stroke patients with a normal angiogram were excluded. There were 89 men and 33 women, age 29 to 80 years (mean age, 56.7 ± 10.9 years). Most patients were admitted within three days after the onset of stroke (85%), and all within 18 days after stroke.The first gastroendoscopic examination (Olympus GTF S-2) was done on the majority of patients within one week after the onset and on all within two to three weeks. On 44 patients the gastroendoscopic examination was done only once, and on the rest of the patients the examination was done severa...

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“…With pentagastrin (0.25 Mg/h) the inhibition declined from about 50% at 1 and 2.5 h to virtually zero at 5 h; the decline may be accounted for by an increased endogenous plasma gastrin concentration due to inhibited acid secretion and from direct stimulation of gastrin secretion by the 1-receptor agonist (compare Hayes, Ardill, Kennedy, Shanks &Buchanan, 1972 andSta4,il &Rehfeld, 1973). Nevertheless, isoprenaline strongly inhibited the rise in enzyme activity induced by infusion of pentagastrin, 16 M/hour.…”

Section: Discussionmentioning

confidence: 98%

Implication of Gastric Mucosal Histamine in Inhibition by Isoprenaline of Pentagastrin‐induced Gastric Secretion

Lundell

Svensson

1974

British J Pharmacology

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The effect of isoprenaline on pentagastrin‐induced gastric secretion was studied in conscious rats with Heidenhain pouches. The influence of isoprenaline on pentagastrin‐induced release and formation of gastric mucosal histamine was also examined. Isoprenaline strongly inhibited pentagastrin‐induced acid secretion, an inhibition which could not be overcome by increasing the dose of pentagastrin. Propranolol blocked the inhibitory effect of isoprenaline on pentagastrin‐induced acid secretion. Isoprenaline enhanced pepsin secretion induced by pentagastrin, an effect which was blocked by propranolol. Isoprenaline reduced the increase in formation and release of gastric mucosal histamine following pentagastrin infusion, an inhibitory influence which was almost completely blocked by propranolol. The inhibition by isoprenaline of pentagastrin‐induced acid secretion is tentatively related to alterations in gastric mucosal histamine occurring simultaneously.

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Stimulation of Gastrin Release by Catecholamines

Cited by 106 publications

References 9 publications

Effect of labetalol, an alpha‐and beta‐adrenoceptor antagonist, on gastric acid and gastrin secretion in man.

Effect of labetalol, an alpha‐and beta‐adrenoceptor antagonist, on gastric acid and gastrin secretion in man.

Acute gastric changes in patients with acute stroke. Part 2: gastroendoscopic findings and biochemical observation of urinary noradrenalin, adrenalin, 17-OHCS and serum gastrin.

Implication of Gastric Mucosal Histamine in Inhibition by Isoprenaline of Pentagastrin‐induced Gastric Secretion

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