Stimulation of erythrocyte phosphatidylserine exposure by chlorpromazine

Akel, Ahmad; Hermle, Tobias; Niemoeller, Olivier M.; Kempe, Daniela S.; Lang, Philipp A.; Attanasio, Philipp; Podolski, Marlis; Wieder, Thomas; Läng, Florian

doi:10.1016/j.ejphar.2005.12.037

Cited by 60 publications

(39 citation statements)

References 41 publications

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“…Some of these diseases may cause eryptosis by stimulating the formation of hemin. Furthermore, several eryptosis-triggering xenobiotics and endogeneous substances have been identified, such as cordycepin [50], methylglyoxal [54], amyloid peptides [53], lipopetides [71] retinoic acid [55], paclitaxel [44], amantadine [23], chlorpromazine [1], ciglitazone [58], cyclosporine [56], Bay-5884 [65], curcumin [4], valinomycin [64], listeriolysin [25], aluminum [57], copper [46], bismuth [13], tin [52], cadmium [68], selenium [67], vanadate [27], gold [69], and arsenic [51]. At least in theory, some of those substances may be effective through stimulation of hemin formation.…”

Section: Discussionmentioning

confidence: 99%

Hemin-induced suicidal erythrocyte death

2009

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Several diseases, such as malaria, sickle cell disease, and ischemia/reperfusion may cause excessive formation of hemin, which may in turn trigger hemolysis. A variety of drugs and diseases leading to hemolysis triggers suicidal erythrocyte death or eryptosis, i.e., cell membrane scrambling and cell shrinkage. Eryptosis is elicited by increased cytosolic Ca 2+ activity and by ceramide. The present study explored whether hemin stimulates eryptosis. Cell membrane scrambling was estimated from annexin Vbinding to phosphatidylserine exposed at the cell surface, cell shrinkage from forward scatter in fluorescence-activated cell sorter analysis, cytosolic Ca 2+ activity from Fluo3 fluorescence and ceramide formation from fluorescencelabeled antibody binding. Exposure to hemin (1-10 μM) within 48 h significantly increased annexin V-binding, decreased forward scatter, increased cytosolic Ca 2+ activity, and stimulated ceramide formation. In conclusion, hemin stimulates suicidal cell death, which may in turn contribute to the clearance of circulating erythrocytes and thus to anemia.

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Section: Discussionmentioning

confidence: 99%

Hemin-induced suicidal erythrocyte death

2009

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“…Eryptosis has been observed in a wide variety of further anemic conditions, including sickle-cell anemia [59,60], beta-thalassemia [55], glucose-6-phosphate dehydrogenase (G6PD)-deficiency [55], phosphate depletion [59], iron deficiency [61], Hemolytic Uremic Syndrome [62], sepsis [63], malaria [64] and Wilson disease [35]. Moreover, enhanced eryptosis could contribute to the anemia following excessive formation, treatment or intoxication with hemolysin Kanagawa [65], listeriolysin [66], PGE 2 [67], lipoxygenase inhibitor Bay-5884 [68], platelet activating factor [69], paclitaxel [70], methylglyoxal [71], chlorpromazine [72], amantadine [73], cyclosporine [34], curcumin [74], amyloid peptides [75], aluminium [34], lead [32], mercury [33] and copper ions [35]. …”

Section: Discussionmentioning

confidence: 99%

Stimulation of Eryptosis by Cadmium Ions

Sopjani

Föller²,

Dreischer

et al. 2008

Cell Physiol Biochem

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Cadmium ions are known to trigger apoptosis. Erythrocytes may similarly undergo suicidal death or eryptosis, which is characterized by exposure of phosphatidylserine at the erythrocyte surface. As macrophages are equipped with phosphatidylserine receptors, they bind, engulf and degrade phosphatidylserine exposing cells. Cellular mechanisms known to trigger cell membrane phospholipid scrambling include increased cytosolic Ca

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“…Eryptosis could be triggered by increase in the cytosolic Ca 21 activity, which leads to cell membrane vesiculation (68) and stimulates cell membrane scrambling resulting in phosphatidylserine exposure at the cell surface (54)(55)(56). Ca 21 further stimulates the cysteine endopeptidase calpain, which degrades the cytoskeleton and thus facilitates cell membrane blebbing (69) (Fig.…”

Section: Signaling In the Stimulation Of Eryptosismentioning

confidence: 99%

“…Suicidal erythrocyte death could be triggered by ligation of specific surface antigens, such as glycophorin-C (41), the thrombospondin-1 receptor CD47 (42) and the death receptor CD95/Fas (43). Further stimulators of eryptosis include ceramide (acylsphingosine) (44), prostaglandin E 2 (45), platelet activating factor (46), anti A IgG antibodies (47), hemolysin from Vibrio parahaemolyticus (48), listeriolysin (49), paclitaxel (50), amantadine (51), azathioprine (52), retinoic acid (53), chlorpromazine (54), cyclosporine (55), methylglyoxal (56), amyloid peptides (57), anandamide (58), Bay-Y5884 (59), curcumin (60), valinomycin (61), aluminium (62), mercury (63), lead (64), gold (65), vanadium (66) and copper (67).…”

Section: Triggers Of Eryptosismentioning

confidence: 99%