Stimulation of cytotoxic and non-cytotoxic functions of natural killer cells by bacterial membrane proteoglycans and ribosomes

Allavena, Paola; Erroi, Annalaura; Pirelli, Anna; Licciardello, Luciano; Mantovani, Alberto

doi:10.1016/0192-0561(89)90096-9

Cited by 15 publications

(3 citation statements)

References 18 publications

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“…This agent (Immucytal) can stimulate the activity of macrophages, polymorphonuclear cells and natural killer cells in leukocytes isolated from human peripheral blood, and to modulate polymorphonuclear leukocyte functions when administered alone or in associations with antibacterials [14,15].…”

Section: Discussionmentioning

confidence: 99%

Short ribosomal prophylaxis in the prevention of clinical recurrences of chronic otitis media in children

Mora

Ralli

Maria

et al. 2004

International Journal of Pediatric Otorhinolaryngology

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SummaryThe aim of this study was to compare the efficacy and the safety of a short oral ribosomal immunotherapy (Immucytal) in the prevention of chronic otitis media in children. Seventy-two patients were enrolled in this study, 41 males and 31 females, aged between 6 and 14 years, with an history of recurrent otitis media. Patients were randomised to receive Immucytal (group A) or placebo (group B) according to the following protocol: one tablet daily in the morning 8 days per month for three consecutive months. Immucytal and placebo were identical in shape and size, in order to maintain double-blind conditions. The efficacy parameters were (evaluated before, at the end and 6 months after the beginning of the therapy): clinical score; changes in immunological parameters; patient's parents assessment of symptoms on a scale from 0 (much worse) to 4 (much improved) and hearing tests. Patients of group A, had an improvement of clinical items measured, serum concentrations of immunoglobulins, subjective patient's parents assessment of symptoms and hearing tests. For all evaluations, a significant difference between treatment groups was found. Using this dosage and posology (shorter than others) the beneficial effects of Immucytal were maintained until the end of the 6-month study period.

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Section: Discussionmentioning

confidence: 99%

Short ribosomal prophylaxis in the prevention of clinical recurrences of chronic otitis media in children

Mora

Ralli

Maria

et al. 2004

International Journal of Pediatric Otorhinolaryngology

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“…Обзор исследований, оценивающих ее клиническую значимость в предотвращении инфекций верхних и нижних дыхательных путей у взрослых и детей были продемонстрированы в случае поликлональ ной стимуляции В [32,33] и Т лимфоцитов [34], активизации полиморфноядерных клеток [35][36][37][38][39], а также макрофагов через фагоцитоз [40], образова нии цитокинов [41][42][43] и стимуляции натуральных клеток киллеров [44]. Таким образом, благодаря своему составу Рибомунил ® имеет двойной меха низм действия, обеспечивающий профилактику как бактериальных, так и вирусных инфекций [24].…”

Section: рибосомальная иммуностимуляцияunclassified

Ribosomal immune stimulation. The review of trials evaluating clinical significance of the point in prevention of upper and lower respiratory tract infections in adults and children

Bellanti¹,

Olivieri²,

Serrano³

2005

Pulʹmonologiâ (Mosk.)

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“…Morphologically they are large granular lymphocytes (LGL) and express various specific surface molecules [20][21][22][23]. NK cells have no immunological memory and no antigenic specificity, and they represent a third and distinct functional population of lymphocytes in addition to T and B cells [24,25], NK cells migrate readily in vitro, and their avidity to adhere to EC can be enhanced by in vitro stimulation of the NK cells by various cytokines and other substances [26][27][28][29]. NK cells express ligands for endothelial cell adhesion molecules, e.g.…”

mentioning

confidence: 99%

Adhesion Molecules Involved in the Interaction of LGL/NK Cells and Human Endothelial Cells Stimulated with Salmonella Bacteria

Pinola

Saksela

1992

Scand J Immunol

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Previously we showed that pretreatment of LGL/NK or HUVE cells with Salmonella bacteria augments the adhesion of LGL/NK cells to endothelium. Here we analyse the roles of HUVEC adhesion molecules VCAM-1, ICAM-1 and E-selectin, and the counter-receptors VLA-4, LFA-1 and SLex in the increase of LGL/NK adhesion to HUVEC, stimulated with Salmonella Minnesota mR595 bacteria, LPS or TNF-alpha. On Salmonella-stimulated HUVEC, VCAM-1 and ICAM-1 were the major binding structures involved, and their effect was additive in monoclonal antibody inhibition experiments. We could demonstrate the induction of both structures on cultured HUVEC after 24 h of Salmonella stimulation in flow cytometric analysis. For Salmonella-stimulated LGL/NK, the principal binding structure was LFA-1. Stimulation of LGL/NK cells did not alter the expression of the adhesion structures (subunits CD11a/CD18, CD49d/CD29), as determined by flow cytometric analysis, and thus the increased adherence is presumably produced by an increased avidity of the receptors on LGL/NK cells. Pretreatment of endothelium or lymphocytes with various stimuli, including Salmonella bacteria or LPS, leads to an activation state which provides for characteristic anchorage sites for the increased migration of LGL/NK cells towards the site of inflammation.

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Stimulation of cytotoxic and non-cytotoxic functions of natural killer cells by bacterial membrane proteoglycans and ribosomes

Cited by 15 publications

References 18 publications

Short ribosomal prophylaxis in the prevention of clinical recurrences of chronic otitis media in children

Short ribosomal prophylaxis in the prevention of clinical recurrences of chronic otitis media in children

Ribosomal immune stimulation. The review of trials evaluating clinical significance of the point in prevention of upper and lower respiratory tract infections in adults and children

Adhesion Molecules Involved in the Interaction of LGL/NK Cells and Human Endothelial Cells Stimulated with Salmonella Bacteria

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