Stimulation of cell motility and expression of late markers of differentiation in human oral keratinocytes by<i>Candida albicans</i>

Rollenhagen, Christiane; Wöllert, Torsten; Langford, George M.; Sundstrom, Paula

doi:10.1111/j.1462-5822.2009.01303.x

Cited by 27 publications

(25 citation statements)

References 94 publications

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“…Invasion into epithelial cells is mediated by both induced endocytosis and active penetration, whereas degradation of epithelial cell junction proteins , such as E-cadherin occurs mainly via proteolysis by secreted aspartyl proteinases [51]. Studies show the potential for C. albicans to manipulate the stratified epithelial cells to a state of differentiation that is more [52]. …”

Section: Discussionmentioning

confidence: 99%

Distribution Patterns of E-Cadherin, Type VII Collagen and Fibronectin in Denture-Related Stomatitis: A Preliminary Study

Bars¹,

Soueidan²

2012

TODENTJ

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The distribution of epithelial E-cadherin, basement membrane type VII collagen, and underlying connective tissues fibronectin were investigated immunohistochemically and compared in normal palatal mucosa and in denture-related stomatitis (DRS) derivatives using monoclonal antibodies.Biopsies of palatal mucosa were obtained from twelve patients enrolled in this study, 8 with type II DRS and 4 with healthy mucosa.Our findings bring to the fore, using the expression of three components (E-cadherin, collagen type VII, fibronectin), the continuities of the disorder among epithelial, basement membrane and connective tissue in the case of DRS. In type II denture-related stomatitis, we found an expression of E-cadherinin all the strata of epithelia, and the diffuse and strong expression of type VII collagen at the interface between connective tissue and epithelial cells with discontinuities in BM. The strong expression of fibronectin in underlying connective tissue with penetration in some areas of the palatal mucosa may be an early consequence of advanced DRS. Nevertheless; no single change is pathognomonic of this inflammatory process.In normal tissues (healthy clinical aspect), E-cadherin was found to be restricted to the upper strata of the epithelia, and type VII collagen revealed thin linear staining in the basement membrane and fibronectin in underlying connective tissue combined epithelia.In the case of denture-related stomatitis DRS, these three markers reflect the immunohistological modifications from the superficial layer of the epithelium to the lamina propria.

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Section: Discussionmentioning

confidence: 99%

Distribution Patterns of E-Cadherin, Type VII Collagen and Fibronectin in Denture-Related Stomatitis: A Preliminary Study

Bars¹,

Soueidan²

2012

TODENTJ

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“…We therefore performed ultrastructural and histopatho- were also the result of supporting in vitro study (22).…”

Section: -D3)mentioning

confidence: 96%

Oral Candidiasis: A Histopathological, Ultrastructural and Immunohistochemical Study

Abe

2014

Int J Oral-Med Sci

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Oral candidiasis presents characteristic histopathological findings. The mucous epithelium at the site of candidiasis is covered by a hyperkeratinized layer. But, the factors leading to hyperkeratosis in candidiasis were unknown. To investigate the factors which led to hyperkeratosis in oral candidiasis, we histopathologicaly, histochemicaly, and ultrastructualy observed the morphological alteration of the epithelial tissue, and studied the factors in connection with those changes immunohistochemically.Candidiasis group (8 cases of papilloma, 5 cases of verrucous hyperplasia), non-candidiasis group (8 cases of papilloma, 7 cases of verrucous hyperplasia), and 5 subjects with normal oral mucosa were selected. Ultrastructually, Candidal hyphe internalized into the epithelial cytoplasmic vacuole resembling endocytosis.Destruction of desmosomal cell junction and deficit of tonofilament was also observed at the tip of the hypha. Immunohistochemistry, weaker expression for E-cadherin was seen in the candidiasis group. Strong positive Ecadherin reaction was seen along the insertion sites of the hyphae. CK13 was negative in non-candidiasis group, and weakly positive in candidiasis groups in the basal layer, respectively. Weakly positive EGFR reactions were observed in the prickle layer in candidiasis group. Inflammatory reaction with NE, CD68, COX-2, CD105 and Ki-67 were markedly observed in candidiasis group.The above result suggested that the hyperkeratosis in oral candidiasis was related with Ecadherin in connection with adhesion and penetration of Candidal hyphae and the precocious expression of the stratified squamous epithelium later differentiated marker CK13. Furthermore, it was surmised that inflammatory response by Candidal hyphae invasion itself led to hyperkeratosis.

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“…HIV infection is involved in changes in the normal vaginal flora that favour the development of local infections, which in turn lead to increased local viral replication [127,128]. These increase sexual transmission of HIV [129].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

OGIJ

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Stimulation of cell motility and expression of late markers of differentiation in human oral keratinocytes byCandida albicans

Cited by 27 publications

References 94 publications

Distribution Patterns of E-Cadherin, Type VII Collagen and Fibronectin in Denture-Related Stomatitis: A Preliminary Study

Distribution Patterns of E-Cadherin, Type VII Collagen and Fibronectin in Denture-Related Stomatitis: A Preliminary Study

Oral Candidiasis: A Histopathological, Ultrastructural and Immunohistochemical Study

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