Stimulation of Bone Healing by Sustained Bone Morphogenetic Protein 2 (BMP-2) Delivery

Fassbender, M; Minkwitz, Susann; Strobel, Catrin; Schmidmaier, Gerhard; Wildemann, Britt

doi:10.3390/ijms15058539

Cited by 42 publications

(35 citation statements)

References 31 publications

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“…It can induce new bone formation in vivo, and have a strong osteoinductive effect on human bone marrow stromal cells in vitro . Therefore, researches on BMP‐2 would be helpful for understanding bone formation, fracture healing, and bone growth around implants . However, BMP‐2 has a very short half‐life and is easy to degenerate after implantation in the human body .…”

Section: Introductionmentioning

confidence: 99%

The interaction of chitosan and BMP‐2 tuned by deacetylation degree and pH value

Wang

et al. 2018

J Biomedical Materials Res

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Integrating proteins with chitosan (CS) can not only improve the biocompatibility of CS, but also enable the sustained release of proteins. The deacetylation degree (DD) and pH conditions are considered as the two most important factors affecting the interaction between CS and proteins. In this study, the effects of CS with different DDs and pH conditions on bone morphogenetic protein‐2 (BMP‐2) adsorption were evaluated using the molecular dynamics (MD) method. The results showed that the interaction energy first increased and then decreased, with the increase of the DD in the range of 0–100%; the strongest interaction was found between BMP‐2 and 75% DD‐CS surface. Furthermore, decreasing pH values favor the interaction between BMP‐2 and CS surfaces. These results are useful to gain a better understanding of the interaction mechanism between polysaccharides and proteins and provide a meaningful reference for the application of CS with different DDs and pH conditions. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 769–779, 2019.

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Section: Introductionmentioning

confidence: 99%

The interaction of chitosan and BMP‐2 tuned by deacetylation degree and pH value

Wang

et al. 2018

J Biomedical Materials Res

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“…The most utilized drug in bone tissue engineering studies has been by far bone morphogenetic protein (BMP). In particular, BMP-2 is known to play an essential role in bone healing, namely by influencing osteogenesis as well as vascularization [3]. This effect has been clearly demonstrated in various studies where BMP-2 was loaded into various types of implantable carriers [4, 5•, 6, 7].…”

Section: Commonly Employed Drugs In Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering Drug Delivery

Costa

2015

Curr Mol Bio Rep

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Tissue engineering shows the potential to address the growing demand for bone tissue substitutes resulting from trauma, disease, and ageing. The utilization of drugs in combination with tissue engineering strategies has resulted in a new generation of osteoinductive scaffolds which are able to improve the speed and quality of new bone formation. This review briefly describes some of the most recent and innovative advances resulting from the combination of drug delivery methodologies with tissue engineering strategies directed at the regeneration of bone tissue. It describes some of the most commonly utilized drugs as well as some of the strategies most commonly employed to accurately direct the delivery of drugs to specific sites and cells. This review also describes several strategies which enable controlled drug release in response to specific stimuli which can be provided by the surrounding environment or medically induced.

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“…In different studies, vancomycin was incorporated into polyurethane or chitosan materials for local delivery to treat and prevent infection (Li, Brown, Wenke, & Guelcher, ; Stinner, Noel, Haggard, Watson, & Wenke, ), whereas another group combined vancomycin delivered in a fibrin gel with alginate beads to deliver stem cells (Hou, Xu, Li, Feng, & Zen, ). In addition to antibiotics, growth factors such as bone morphogenetic proteins are often included in bone regenerative strategies for osteoinduction (Brown et al, ; Faßbender, Minkwitz, Strobel, Schmidmaier, & Wildemann, ; Jiang et al, ; Li, Vepari, Jin, Kim, & Kaplan, ). The efficacy of these complex systems however must be confirmed at the scaffold level due to the effects of infection on the graft itself.…”

Section: Introductionmentioning

confidence: 99%

In vivo hydroxyapatite scaffold performance in infected bone defects

et al. 2019

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Critically sized bone defects are often compounded by infectious complications. The standard of care consists of bone autografts with systemic antibiotics. These injuries and treatments lead to donor site morbidity, antibiotic resistant strains of bacteria, and often end stage amputation. This study proposes an alternative to the autograft using a porous, hydroxyapatite (HA) scaffold evaluated with and without infection and antibiotics. Twenty‐four New Zealand white rabbits received either our HA scaffold or a pulverized autograft (PBA) within a surgically created critical‐sized defect in the femur. The two grafts were evaluated in either septic or aseptic defects and with or without antibiotic treatment. The HA scaffolds were characterized with micro computed tomography. Post‐euthanasia, micro computed tomography, histology, and white blood cells component analysis were completed. The HA had significantly greater (p < .001) mineralization to total volume than the PBA groups with 27.56% and 14.88%, respectively, and the septic HA groups were significantly greater than the aseptic groups both with and without antibiotics (p = .016). The bone quality denoted by bone mineral density was also significantly greater (p < .001) in the HA groups (67.01 ± 0.38 mgHA/cm3) than the PBA groups (64.66 ± 0.85 mgHA/cm3). The HA scaffold is a viable alternative to the bone autograft in defects with and without infection as shown by the quality and quantity of bone.

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Stimulation of Bone Healing by Sustained Bone Morphogenetic Protein 2 (BMP-2) Delivery

Cited by 42 publications

References 31 publications

The interaction of chitosan and BMP‐2 tuned by deacetylation degree and pH value

The interaction of chitosan and BMP‐2 tuned by deacetylation degree and pH value

Bone Tissue Engineering Drug Delivery

In vivo hydroxyapatite scaffold performance in infected bone defects

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