2000
DOI: 10.1016/s0169-5002(00)80670-4
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Stimulation of be-ta1 integrin down-regulates ICAM-1 expression and ICAM-1 dependent adhesion of lung cancer cells through focal adhesion kinase

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Cited by 21 publications
(21 citation statements)
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“…Integrins, in turn, have been reported to downregulate ICAM1 expression via FAK [63] , suggesting that migration requires the downregulation of this adhesion molecule. It was therefore not surprising at first that FGF2 decreased ICAM1 expression while increasing migration via CCL2, all phenomena depending on FAK.…”
Section: Discussionmentioning
confidence: 99%
“…Integrins, in turn, have been reported to downregulate ICAM1 expression via FAK [63] , suggesting that migration requires the downregulation of this adhesion molecule. It was therefore not surprising at first that FGF2 decreased ICAM1 expression while increasing migration via CCL2, all phenomena depending on FAK.…”
Section: Discussionmentioning
confidence: 99%
“…The potential involvement of intercellular adhesion molecule-1 (ICAM-1 or CD54), a ligand of lymphocyte function-associated antigen-1 (LFA-1), in the interaction between CTL and target cells and thus in the regulation of CTL-mediated cytotoxicity has been well documented in a variety of studies (6)(7)(8). There is strong evidence that the engagement of LFA-1 on CTL by ICAM-1 on target cells is essential for T-cell activation and for directing the released of cytolytic granules into the tumor cells (9)(10)(11).…”
Section: Introductionmentioning
confidence: 99%
“…Among these alterations, an increase in expression of immediate-early response genes as well as different transcription factors in monocytes responding to injury or infection (21), an increase in c-myc protein levels in breast epithelial cells (22), a decrease in intercellular adhesion molecule-1 expression in lung cancer cells (23), the induction of matrix metalloproteinase gene expression (24), and >32 genes differentially modulated in salivary epithelial cells undergoing morphologic differentiation (25). Finally, expression of h 1 variants per se has been shown to increase p21 mRNA levels in hepatocellular carcinoma cells (26) or p27 kip1 levels (27) in several cell types and a V h 3 expression in LNCaP prostate cancer cells causes increased cdc2 mRNA, protein, and kinase activity levels (28).…”
Section: Introductionmentioning
confidence: 99%