Stimulation of Alveolar Macrophages in Asthmatic Patients After Local Provocation Test

Tonnel, A. B.; Gosset, P.; Joseph, M.; Fournier, E; Càpron, André

doi:10.1016/s0140-6736(83)92356-5

Cited by 127 publications

(46 citation statements)

References 12 publications

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“…Allergy as a local disease. Endobronchial allergen challenge carried out on nonasthmatic patients with seasonal rhinitis induced bronchoconstriction (1989) and the secretion of proinflammatory mediators and cytokines as well as the recruitment of inflammatory cells in the lavage fluid (1990)(1991)(1992). These studies combine to indicate that patients with nasal symptoms can develop asthma only if the allergen is properly administered into the airways.…”

Section: Commonalities and Differences In Mechanisms Between Rhinitismentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,818

1,761

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Section: Commonalities and Differences In Mechanisms Between Rhinitismentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,818

1,761

View full text Add to dashboard Cite

“…Both neutrophils and macrophages may contribute to eosinophil-dominated inflammatory reaction via release of eicosanoids and reactive oxygen species and cytokines [255][256][257][258]. Toxic properties by intact neutrophils and macrophages are considerably increased when eosinophil-derived EPO is bound to the target cell surface, presumably due to a more sufficient utilization of H 2 O 2 by the phagocytes [259].…”

Section: Neutrophils and Macrophagesmentioning

confidence: 99%

Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part I)

Kroegel¹,

Virchow²,

Luttmann³

et al. 1994

Eur Respir J

129

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P Pu ul lm mo on na ar ry y i im mm mu un ne e c ce el ll ls s i in n h he ea al lt th h a an nd d d di is se ea as se e: : t th he e e eo os si in no op ph hi il l l le eu uc co oc cy yt te e ( (P Pa ar rt t I I) ) ABSTRACT: Increasing evidence has accumulated to suggest that eosinophils play a key role in the pathogenesis of asthma and other pulmonary diseases by damaging infiltrated bronchial tissue and lung parenchyma. The first part of this review on eosinophils describes the cellular characteristics and properties of the cell, which help in understanding its role in disease. The article focuses on origin, maturation and differentiation of the eosinophil, its morphological and phenotypical properties, as well as its preformed and newly generated mediators of inflammation. The cause and putative significance of eosinophil heterogeneity in respect to function and density will also be discussed. In addition, the naturally occurring mediators through which eosinophils are activated and communicate with other inflammatory cells are outlined.The first part closes with new aspects of eosinophil recruitment from the circulation into perivascular tissue, including nonselective and putative selective adhesion mechanisms and chemotaxis.

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“…Airway macrophages are found in increased numbers in asthmatic bronchi (26). They appear to be in an activated state and release enzymes (27), eicosanoids (28), PAF, oxygen free radicals (29) and cytokines, including TNF (30) that might be deleterious to the bronchi.…”

Section: Inflammation and Repair In Asthmamentioning

confidence: 99%