Stimulation of adenosine A1 receptors prevents the EEG arousal due to dopamine D1 receptor activation in rabbits

Popoli, Patrizia; Ferré, Sergi; Pézzola, Antonella; Reggio, Rosaria; Carolis, A. Scotti de; Fuxé, Kjell

doi:10.1016/0014-2999(96)00242-7

Cited by 23 publications

(17 citation statements)

References 14 publications

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“…Activation of NMDA receptors conversely leads to decreased DARPP-32 phosphorylation (Halpain et al 1990). A fourth interaction is between dopamine D 1 receptors and adenosine A 1 receptors, which have been shown to act antagonistically (Ferré et al 1994(Ferré et al , 1998Popoli et al 1996). All these interactions may be functionally connected (Harvey and Lacey 1997).…”

Section: Interactionsmentioning

confidence: 91%

Structure and function of adenosine receptors and their genes

Fredholm

Arslan

Halldner

et al. 2000

Naunyn-Schmied Arch Pharmacol

511

497

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Four adenosine receptors have been cloned from many mammalian and some non-mammalian species. In each case the translated part of the receptor is encoded by two separate exons. Two separate promoters regulate the A1 receptor expression, and a similar situation may pertain also for the other receptors. The receptors are expressed in a cell and tissue specific manner, even though A1 and A2B receptors are found in many different cell types. Emerging data indicate that the receptor protein is targeted to specific parts of the cell. A1 and A3 receptors activate the Gi family of G proteins, whereas A2A and A2B receptors activate the Gs family. However, other G proteins can also be activated even though the physiological significance of this is unknown. Following the activation of G proteins several cellular effector pathways can be affected. Signaling via adenosine receptors is also known to interact in functionally important ways with signaling initiated via other receptors.

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Section: Interactionsmentioning

confidence: 91%

Structure and function of adenosine receptors and their genes

Fredholm

Arslan

Halldner

et al. 2000

Naunyn-Schmied Arch Pharmacol

511

497

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“…As previously reported [10], the baseline EEG tracing recorded from acute rabbits was characterized by highvoltage, low-frequency waves and spindles ('synchroniza tion', fig. 1A).…”

Section: Resultsmentioning

confidence: 74%

“…Specifically, while the acute EEG preparation has proved to be suitable for the study of drug-induced EEG arousal [10], the EEG effects of sedative drugs (which induce syn chronization and slowing of the EEG tracing) would be better studied on chronically implanted rabbits. The choice of the most appropriate EEG preparation would allow to better recognize drug-induced EEG effects, to obtain more reproducible results, and to use a reduced number of animals.…”

Section: Discussionmentioning

confidence: 99%

Baseline Electroencephalographic Tracings in Rabbits Differ Significantly According to ‘Acute’ or ‘Chronic’ Preparation

Pézzola

Reggio²,

Popoli³

1997

Neuropsychobiology

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Baseline electroencephalographic (EEG) tracings recorded from ‘acute’ and ‘chronic’ rabbits were compared by computerized spectral analysis. The results showed that baseline EEG activity of rabbits differ significantly and markedly according to acute or chronic preparation. It is suggested that this finding should be taken into account when studying the EEG effects of centrally acting drugs.

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“…Noxious stimulation also travels to the brainstem reticular formation, especially the ascending reticular activating system, and may evoke an EEG arousal response [15,16]. However, EEG arousal is a very complex phenomenon, in which several activating systems and neurotransmitters are involved [12,13,15,16]. We speculate that a difference in intensity of noxious stimulation, which travels along the vagal and glossopharyngeal afferents, through the brainstem and spinal cord, to the sympathetic nervous system, disappears during extensive processing of impulses from the brainstem to the cortex under propofol anaesthesia.…”

Section: Discussionmentioning

confidence: 99%

Electroencephalographic arousal response during tracheal intubation and laryngeal mask airway insertion after induction of anaesthesia with propofol

Inada¹,

Shingu

Nakao

et al. 1999

Anaesthesia

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SummaryLaryngoscopy and tracheal intubation, or insertion of a laryngeal mask airway may lead to an arousal response on the electroencephalogram. We studied whether more intense stimulation (laryngoscopy and tracheal intubation) causes a greater arousal response than less intense stimulation (laryngeal mask airway insertion). Thirty-four patients (ASA I-II) were anaesthetised with propofol 3 mg.kg ¹1 , followed by vecuronium 0.15 mg.kg ¹1 and a propofol infusion of 10 mg.kg ¹1.h ¹1. Three minutes after induction of anaesthesia, either laryngoscopy and tracheal intubation (n ¼ 18), or laryngeal mask airway insertion (n ¼ 16) was performed. Laryngoscopy and tracheal intubation caused a significantly greater increase in blood pressure (but not heart rate) than laryngeal mask airway insertion (p < 0.05 Noxious stimulation, such as tracheal intubation and laryngeal mask airway (LMA) insertion induce an arousal response on the electroencephalogram (EEG) [1][2][3][4]. A previous study showed that different anaesthetics are associated with different degrees of EEG arousal response when presented with a similar noxious stimulation [3]. However, whether noxious stimulations of different intensity cause different degrees of EEG arousal response has not been studied. We hypothesised that more intense noxious stimulation would cause a greater EEG arousal response. Laryngoscopy and tracheal intubation present a greater noxious stimulation than LMA insertion [5-9], both usually being restricted to the time of induction of anaesthesia. Therefore, we compared, after the induction of anaesthesia with propofol, EEG arousal during laryngoscopy followed by tracheal intubation with that during LMA insertion. Methods

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Stimulation of adenosine A1 receptors prevents the EEG arousal due to dopamine D1 receptor activation in rabbits

Cited by 23 publications

References 14 publications

Structure and function of adenosine receptors and their genes

Structure and function of adenosine receptors and their genes

Baseline Electroencephalographic Tracings in Rabbits Differ Significantly According to ‘Acute’ or ‘Chronic’ Preparation

Electroencephalographic arousal response during tracheal intubation and laryngeal mask airway insertion after induction of anaesthesia with propofol

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