Stimulation of acyl-CoA oxidase by α-linolenic acid-rich perilla oil lowers plasma triacylglycerol level in rats

Kim, Hyekyeong; Choi, Hyeong In

doi:10.1016/j.lfs.2004.10.082

Cited by 21 publications

(16 citation statements)

References 44 publications

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“…It has been reported that the addition of 0.5% of trans-10, cis-12 conjugated linoleic acid isomer to the diet increases liver fatty acid oxidation leading to decreased hepatic and serum triacylglycerols [17]. Stimulation of acetyl-CoA oxidase by alpha-linolenic acid-rich perilla oil was reported to lower plasma triacylglycerol level in rats [18]. However, Staels et al have shown that fibrates down regulate APOClll expression independent of induction of peroxisomal acyl coenzyme A oxidase [19].…”

Section: Resultsmentioning

confidence: 99%

Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms

et al. 2008

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Previously we have shown that intestinal cells efficiently take up oxidized fatty acids (OxFAs) and that atherosclerosis is increased when animals are fed a high cholesterol diet in the presence of oxidized linoleic acid. Interestingly, we found that in the absence of dietary cholesterol, the oxidized fatty acid fed low-density lipoprotein (LDL) receptor negative mice appeared to have lower plasma triglyceride (TG) levels as compared to animals fed oleic acid. In the present study, we fed C57BL6 mice a normal mice diet supplemented with oleic acid or oxidized linoleic acid (at 18 mg/animal/ day) for 2 weeks. After the mice were sacrificed, we measured the plasma lipids and collected livers for the isolation of RNA. The results showed that while there were no significant changes in the levels of total cholesterol and high-density lipoprotein cholesterol (HDLc), there was a significant decrease (41.14%) in the levels of plasma TG in the mice that were fed oxidized fatty acids.The decreases in plasma TG levels were accompanied by significant increases (P < 0.001) in the expressions of APOA5 and acetyl-CoA oxidase genes as well as a significant (P < 0.04) decrease in APOClll gene expression. Oxidized lipids have been suggested to be ligands for peroxisome proliferator-activated receptor (PPARα). However, there were no increases in the mRNA or protein levels of PPARα in the oxidized linoleic acid fed animals. These results suggest that oxidized fatty acids may act through an APOA5/APOClll mechanism that contributes to lowering of TG levels other than PPARα induction.

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Section: Resultsmentioning

confidence: 99%

Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms

et al. 2008

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“…Lipid accumulations in the perilla oil groups were less than the lard fed groups regardless of animal type, indicating that ALA (66.8 vs. 0.5% to the total fatty acid Values are mean±SD (n=5 for wild type mice group, n=9 for apoE KO mice group); Different superscript letters within a row indicate significantly differences (p<0.05); NS, not significant for perilla oil and lard, respectively) could be recognized as a responsible principle compound for these action. N-3 PUFAs are known to have benefits on reducing plasma and hepatic lipids (7)(8)(9)25). Suppression of fatty acid synthase (FAS) in the liver plays a significant role in controlling the serum lipid levels which might subsequently affect hepatic lipid accumulation.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, n-3 PUFAs are known to have benefits on reducing plasma and hepatic lipids (7)(8)(9)(10), and their roles as a gene regulator in the lipid metabolism have also been extensively reviewed (11). Fish oil exerted inhibitory effects on hepatic TG accumulation in mouse by down regulating SREBP-1c (12).…”

Section: Introductionmentioning

confidence: 99%

Perilla oil rich in α-linolenic acid suppresses hepatic SREBPs and NF-κB expression in hypercholesterolemia-induced apolipoprotein E knockout mice

Lee

Song

2012

Food Sci Biotechnol

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Abstracts This study is to examine whether perilla oil rich in α-linolenic acid, n-3 fatty acid, would affect the expression of transcription factors involved in the regulation of hepatic lipid metabolism and in the inflammatory responses. Apolipoprotein E knockout (apoE KO) mice (n=18) and its wild type mice (n=10) were fed a high cholesterol diet containing perilla oil or lard for 10 weeks. In apoE KO mice, perilla oil group demonstrated significant decrease in hepatic triglyceride (7.95%) and total cholesterol concentrations (35.76%) than lard fed group. Expression for nuclear transcription factor, sterol regulatory elementbinding protein (SREBP)-1 (32.37%) and SREBP-2 (25.6%) were dropped off whereas that for the peroxisome proliferator-activated receptor α elevated (48.15%, p<0.05), compared with lard group. Inhibition in nuclear factor-κB and increase in inhibitor κ-Bα expressions subsequently decreased cyclooxygenase-2 and inducible nitric oxide synthase expressions in the perilla oil group. Beneficial effects of perlla oil observed in apoE KO mice were greater than those from the wild type mice.

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“…These molecule exhibit plasma triacylglycerol lowering effect (Kim & Choi, 2005). Ascorbic acid is also abundant in perilla leaves, and its content in the leaf can be controlled by applying artificial light regimes (Iwai et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Enhanced accumulation of caffeic acid, rosmarinic acid and luteolin-glucoside in red perilla cultivated under red diode laser and blue LED illumination followed by UV-A irradiation

Iwai

Ohta

Suzuki

2010

Journal of Functional Foods

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Stimulation of acyl-CoA oxidase by α-linolenic acid-rich perilla oil lowers plasma triacylglycerol level in rats

Cited by 21 publications

References 44 publications

Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms

Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms

Perilla oil rich in α-linolenic acid suppresses hepatic SREBPs and NF-κB expression in hypercholesterolemia-induced apolipoprotein E knockout mice

Enhanced accumulation of caffeic acid, rosmarinic acid and luteolin-glucoside in red perilla cultivated under red diode laser and blue LED illumination followed by UV-A irradiation

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