Stimulation of 5-HT1A and 5-HT1B receptors in brain regions and its effects on male rat sexual behaviour

Fernández‐Guasti, Alonso; Escalante, A.; Ahlénius, Sven; Hillegaart, Viveka; Larsson, Knut

doi:10.1016/0014-2999(92)90662-n

Cited by 104 publications

(65 citation statements)

References 23 publications

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“…It is not clear which 5-HT receptor subtypes mediate these effects. However, systemic injections of a 5-HT 2 agonist (Foreman et al, 1989) and intracranial injections of a 5-HT 1B agonist (Fernandez-Guasti et al, 1992) have impaired copulatory ability of male rats.…”

Section: Discussionmentioning

confidence: 99%

“…Because of its importance in the expression of masculine sexual behaviors, 5-HT may mediate inhibitory influences by altering MPOA functioning. Microinjection of 5-HT into the M POA of male rats has been shown to impair sexual activity (Verma et al, 1989;Fernandez-Guasti et al, 1992). Furthermore, results from ex vivo and in vivo analysis of 5-HT activity in the POA have led to the suggestion that 5-HT may be released in this area after ejaculation and may promote the postejaculatory interval (PEI).…”

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confidence: 99%

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Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats

et al. 1997

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Serotonin (5-HT) is generally inhibitory to masculine sexual behavior. It has been suggested that 5-HT released after ejaculation may promote the sexual quiescence of the postejaculatory interval (PEI). The following experiments were conducted to test (1) whether extracellular 5-HT increases in either the anterior lateral hypothalamic area (LHA A ) or the medial preoptic area (MPOA) of male rats after ejaculation; (2) whether increasing 5-HT in these sites, by microinjecting the selective serotonin reuptake inhibitor alaproclate, could inhibit copulatory abilities; and (3) whether copulation deficits produced by alaproclate were attributable to locomotor impairments. The effects of local application of alaproclate on extracellular 5-HT levels in the LHA A and the MPOA were also tested. Extracellular serotonin was measured in all experiments using in vivo microdialysis.Ejaculation was correlated with enhanced 5-HT release from the LHA A ; no 5-HT increases were observed before ejaculation, and levels were decreased toward basal values during a subsequent copulatory series. Elevating 5-HT in the LHA A by microinjecting alaproclate inhibited copulation by increasing the latency to mount, intromit, and ejaculate. This inhibition did not result from nonspecific locomotor impairments. In the MPOA, 5-HT release remained stable throughout copulation, and microinjecting alaproclate into this site did not significantly alter sexual behavior.These data support the large body of evidence suggesting that 5-HT is inhibitory to masculine sexual behavior. Furthermore, the LHA A , but not the MPOA, may be one site responsible for serotonergic inhibition of copulation during the PEI.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats

et al. 1997

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“…Apart from their nonselective b-adrenoreceptor blockade, propranolol and pindolol in addition exhibit binding affinity for various 5-HT 1 receptor subtypes, 21 which have been demonstrated in many studies to modify sexual behavior. 22,23 There is also clinical and experimental evidence for the reduction of testosterone levels in the course of continued medication with propranolol. 24 These various mechanisms may explain why propranolol seems to have more side effects on sexual behavior than other b-blockers.…”

Section: Discussionmentioning

confidence: 99%

The Influence of prolonged β-blockers treatment on male rabbit's sexual behavior and penile microcirculation

et al. 2006

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The aim of the study was to assess the effect of the prolonged intake of three b-blocking drugs (propranolol, metoprolol and nebivolol) on the sexual behavior and penile microcirculation of rabbits. Drugs were administered p.o. for 9 weeks and every three weeks in each group (n ¼ 13) one subgroup (n ¼ 7) performed behavioral tests, whereas in the second subgroup (n ¼ 6) penile microcirculation was measured with a laser Doppler flowmeter. The copulation studies revealed significant impairment of sexual function only in the propranolol treated group. The measured behavioral parameters suggest that at a given dose propranolol affects more performance rather than arousal aspects of rabbits' sexual behavior. In the course of the whole study no significant difference was observed among groups in penile blood flow. The data indicate that among the b-blockers given only propranolol interferes with sexual behavior, and that b-blockers do not appear to have a negative effect on penile microcirculation.

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“…On the other hand, a few studies have demonstrated that manipulation of the NAc affected copulation performance (Fernández-Guasti et al, 1992;Kippin et al, 2004). The NAc plays a critical role in partner-preference formation in male prairie voles (Aragona et al, 2006); moreover, in male rats, it is activated by odors associated with females (West et al, 1992;Kippin et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Neuronal Responses in the Nucleus Accumbens Shell during Sexual Behavior in Male Rats

Matsumoto¹,

Urakawa²,

Hori³

et al. 2012

J. Neurosci.

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Previous behavioral studies have indicated that the nucleus accumbens (NAc) shell of a male rat is involved in its sexual behavior; however, no previous studies have investigated neuronal activities in the male rat NAc shell during sexual behavior. To investigate this issue, we recorded single unit activities in the NAc shell of male rats during sexual behavior. Of 123 NAc shell neurons studied, 53, 47, and 40 neurons exhibited significantly changed firing rates at various times during intromission, genital auto-grooming, and sniffing of females, respectively. The two types of NAc shell neurons [putative fast spiking interneurons (pFSIs) and medium spiny neurons (pMSNs)] responded differently during sexual behavior. First, more pFSIs than pMSNs exhibited inhibitory responses to thrusting with intromission and genital grooming, while pFSIs and pMSNs responded similarly to sniffing of females. Second, both pFSIs and pMSNs responded differently to thrusting with and without intromission. Furthermore, NAc shell neuronal activity was significantly different across the different phases of sexual behavior, and the number of NAc shell neurons with delta oscillation, which is related to behavioral inhibition, and high gamma oscillation, which is related to reward perception, increased after ejaculation. Together, our results suggest that the NAc shell is deeply involved in sexual behavior, and changes in NAc shell neuronal activity are related to performance of sexual behavior, encoding cues or contexts related to sexual behavior, reward-related processing, and the inhibition of sexual behavior after ejaculation.

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Stimulation of 5-HT1A and 5-HT1B receptors in brain regions and its effects on male rat sexual behaviour

Cited by 104 publications

References 23 publications

Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats

Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats

The Influence of prolonged β-blockers treatment on male rabbit's sexual behavior and penile microcirculation

Neuronal Responses in the Nucleus Accumbens Shell during Sexual Behavior in Male Rats

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