Stimulation magnétique transcrânienne répétée dans la prise en charge des épisodes dépressifs majeurs : facteurs prédictifs de réponse thérapeutique

Dumas, R.; Padovani, R.; Richieri, Raphaëlle; Lançon, Christophe

doi:10.1016/j.encep.2011.08.004

Cited by 29 publications

(11 citation statements)

References 33 publications

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“…This is due to the naturalistic design of the study, which is not strictly optimal as it would be in a controlled assay. Second, we did not record and analyze the duration of the current episode, or the degree of pharmacological resistance, which seem to be predominant in rTMS treatment outcome (Dumas et al, 2012;Fregni et al, 2006;Lisanby et al, 2009). Third, the switch from HF to LF stimulations may also be a limitation as the number of subjects receiving HF stimulations is very small in comparison with the group receiving LF stimulation.…”

Section: Discussionmentioning

confidence: 96%

rTMS for pharmacoresistant major depression in the clinical setting of a psychiatric hospital: Effectiveness and effects of age

Ciobanu¹,

Girard²,

Marin³

et al. 2013

Journal of Affective Disorders

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Section: Discussionmentioning

confidence: 96%

rTMS for pharmacoresistant major depression in the clinical setting of a psychiatric hospital: Effectiveness and effects of age

Ciobanu¹,

Girard²,

Marin³

et al. 2013

Journal of Affective Disorders

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“…Compte tenu de l'hétérogénéité de la dépression quant à son origine, ses mécanismes, et sa présentation clinique, quel profil de patient est susceptible de répondre plus significativement à la tDCS et donc constituer une meilleure indication ? Comme pour la rTMS [53][54][55], on peut aussi se demander s'il existe des facteurs prédictifs de réponse à la tDCS et si la tDCS est susceptible d'améliorer la qualité de vie des patients au quotidien, notamment les patients âgés, au-delà même des effets statistiques démontrés sur des scores de dépression. Toutes ces questions et bien d'autres encore restent en suspens.…”

Section: Discussionunclassified

La stimulation transcrânienne à courant continu (tDCS) dans la dépression : bilan de près d’une décennie de recherche clinique

Palm

Ayache²,

Padberg³

et al. 2016

L'Encéphale

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“…With regard to recent scientific literature, various points must be specifically investigated: controlled comparison of protocols with the enrolment of a homogeneous population in terms of treatment and clinical form of the condition (most studies combine both bipolar and unipolar disorder); duration of the effect with longitudinal follow-up; and predictive response factors [20]. The main predictive therapeutic response factors identified to date are age, duration of the episode, degree of therapeutic resistance, clinical profile and, in particular, cognitive impairment and psychomotor retardation [21, 22]. A study of cortical excitability, which reflects the gabaergic and glutamatergic transmission of cortical interneurones (IN), could also prove promising in distinguishing neurostimulation responder profiles.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of intermittent Theta Burst Stimulation (iTBS) and 10-Hz high-frequency repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant unipolar depression: study protocol for a randomised controlled trial

Bulteau

Sébille

Fayet

et al. 2017

Trials

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BackgroundThe treatment of depression remains a challenge since at least 40% of patients do not respond to initial antidepressant therapy and 20% present chronic symptoms (more than 2 years despite standard treatment administered correctly). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy but still not ideal. Intermittent Theta Burst Stimulation (iTBS), which has only been used recently in clinical practice, could have a faster and more intense effect compared to conventional protocols, including 10-Hz high-frequency rTMS (HF-rTMS). However, no controlled study has so far highlighted the superiority of iTBS in resistant unipolar depression.Methods/designThis paper focuses on the design of a randomised, controlled, double-blind, single-centre study with two parallel arms, carried out in France, in an attempt to assess the efficacy of an iTBS protocol versus a standard HF- rTMS protocol. Sixty patients aged between 18 and 75 years of age will be enrolled. They must be diagnosed with major depressive disorder persisting despite treatment with two antidepressants at an effective dose over a period of 6 weeks during the current episode. The study will consist of two phases: a treatment phase comprising 20 sessions of rTMS to the left dorsolateral prefrontal cortex, localised via a neuronavigation system and a 6-month longitudinal follow-up. The primary endpoint will be the number of responders per group, defined by a decrease of at least 50% in the initial score on the Montgomery and Asberg Rating Scale (MADRS) at the end of rTMS sessions. The secondary endpoints will be: response rate 1 month after rTMS sessions; number of remissions defined by a MADRS score of <8 at the endpoint and 1 month after; the number of responses and remissions maintained over the next 6 months; quality of life; and the presence of predictive markers of the therapeutic response: clinical (dimensional scales), neuropsychological (evaluation of cognitive functions), motor (objective motor testing) and neurophysiological (cortical excitability measurements).DiscussionThe purpose of our study is to check the assumption of iTBS superiority in the management of unipolar depression and we will discuss its effect over time. In case of a significant increase in the number of therapeutic responses with a prolonged effect, the iTBS protocol could be considered a first-line protocol in resistant unipolar depression.Trial registrationClinicalTrials.gov, Identifier NCT02376491. Registered on 17 February 2015 at http://clinicaltrials.gov.Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-016-1764-8) contains supplementary material, which is available to authorized users.

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Stimulation magnétique transcrânienne répétée dans la prise en charge des épisodes dépressifs majeurs : facteurs prédictifs de réponse thérapeutique

Cited by 29 publications

References 33 publications

rTMS for pharmacoresistant major depression in the clinical setting of a psychiatric hospital: Effectiveness and effects of age

rTMS for pharmacoresistant major depression in the clinical setting of a psychiatric hospital: Effectiveness and effects of age

La stimulation transcrânienne à courant continu (tDCS) dans la dépression : bilan de près d’une décennie de recherche clinique

Efficacy of intermittent Theta Burst Stimulation (iTBS) and 10-Hz high-frequency repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant unipolar depression: study protocol for a randomised controlled trial

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