STIMULATION BY Β2-Adrenergic RECEPTORS OF THE PRODUCTION OF CYCLIC AMP AND PROGESTERONE IN RAT OVARIAN TISSUE

Ratner, Albert; Weiss, Gerald K.; Sanborn, Carolyn R.

doi:10.1677/joe.0.0870123

Cited by 37 publications

(17 citation statements)

References 13 publications

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“…This phenomenon is produced by catecholamines and the specific agonists of the ␤ 2 type when they act on the specific receptors of the ovary (Ratner et al, 1980). Besides, it has been reported that the adrenergic effect on granulosa cells in culture totally depends on the presence of FSH (Adashi and Hsueh, 1981;Aguado and Ojeda, 1984a,b).…”

Section: Catecholamines and Adrenergicmentioning

confidence: 98%

“…(Aguado and Ojeda, 1984a,b). It is important to emphasize that granulosa as well as luteal cells have adrenergic receptors (Adashi and Hsueh 1981;Aguado et al, 1982;Ratner et al, 1980) but they are not directly innervated (Erikson et al 1985;Hsueh et al, 1984).…”

Section: Catecholamines and Adrenergicmentioning

confidence: 99%

“…These receptors are coupled to the release of progesterone and androgens, which can be demonstrated by short incubation of complete ovaries as well as by culture of the ovarian cells (Adashi and Hsueh, 1981;Aguado et al, 1982;Dyer and Erickson, 1985;Ratner et al, 1980).…”

Section: Innervation and Ovarian Functionmentioning

confidence: 99%

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Role of the central and peripheral nervous system in the ovarian function

Aguado

2002

Microscopy Res & Technique

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This review attempts to give a comprehensive overview of ovarian innervation, considering the whole nervous system and its different levels that may modify the ovarian function. The connection between the ovary and the central nervous system through the autonomic pathways, including the peripheral ganglia, is highlighted. The evidence obtained over the last years highlights the role of the superior ovarian nerve (SON) in the ovarian phenomena. Besides, the effect on the ovary of conventional neurotransmitters and others such as indolamines and peptides, which have been found in this organ, are discussed. Various reproductive diseases have been studied almost exclusively from the endocrine point of view. It is evident that a better knowledge about the role of the neural factors involved in the ovarian physiology may facilitate the understanding of some of these. A review of the concepts and an update of some experimental designs is made that permits clarifying several aspects of the relationship between the neural system and the ovary. At present, there is no doubt that the innervation of the ovary is involved in several physiological aspects of this gland function. However, the relationship of some levels of the nervous system and the ovary offer a wide avenue for future research.

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Section: Catecholamines and Adrenergicmentioning

confidence: 98%

Section: Catecholamines and Adrenergicmentioning

confidence: 99%

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Role of the central and peripheral nervous system in the ovarian function

Aguado

2002

Microscopy Res & Technique

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“…The physiological significance of ovarian adrenergic innervation remains unresolved, in spite of reports of the involvement of sympathetic nerves in ovulation (13,14) and that catecholamines can stimulate progesterone production by granulosa (15)(16)(17) and corpus luteum cells (18)(19)(20)(21)(22)(23)(24). Although progesterone production by granulosa and luteal cells can be stimulated by catecholamines, neither cell type is directly innervated.…”

mentioning

confidence: 99%

Norepinephrine Amplifies Human Chorionic Gonadotropin-Stimulated Androgen Biosynthesis by Ovarian Theca-Interstitial Cells*

Dyer

Erickson

1985

Endocrinology

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Ovarian theca-interstitial cells, when cultured in serum-free medium, secreted androgens in response to hCG stimulation. This production was dependent on time (maximum production attained after 96 h) and dose (half-maximal effective dose of hCG, 9 ng/ml). When the sympathomimetics norepinephrine, epinephrine, and isoproterenol were added to the medium, androgen production in response to hCG was enhanced by 100-300%. The ability of the catecholamines to stimulate androgen production was dependent on the continuous presence of hCG. Treatment with catecholamines alone did not induce theca-interstitial cells to produce androgens. Catecholamine stimulation of steroid hormone metabolism was selective for intermediates in the delta 4-pathway, with greatest increases occurring in the production of androstenedione and testosterone. It was found that the effect of the catecholamines on androgen production was dependent on both beta 1-and beta 2-adrenergic receptors. The acquisition of catecholamine responsiveness was specific to hCG; if theca-interstitial cells were induced to differentiate with either prostaglandin E2 or cholera toxin, then isoproterenol did not enhance androgen synthesis. The catecholamine-induced increases in androgen production were not due to a granulosa cell contribution of steroid. The interstitial cells are the only steroid-producing cells in the ovary that are directly innervated by norepinephrine-containing fibers of the sympathetic nervous system. Our finding of catecholamine-augmented androgen production provides a direct link between the autonomic nervous system and regulation of ovarian steroid synthesis.

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“…Since the effects of the mainly P?-adrenergic hexoprenaline on P production could be inhibited by propranolol, and since the rat ovary contains mostly p2-adrenergic recep tors [7,14], it can be supposed that the effects of hexoprenaline on P secretion are mediated through p2-adrenergic receptors. Catecholamine receptors of luteal cells are independent of gonadotropic hormone re ceptors and catecholamines activate adenyl ate-cyclase like gonadotropic hormones [6].…”

Section: Discussionmentioning

confidence: 99%

Increase of Progesterone Production in Human and Rat Luteal Cells by Beta-Adrenergic Stimulation

Horvath

Varga

Zsolnai

et al. 1987

Gynecol Obstet Invest

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The effects of the Β₂-adrenergic agonist hexoprenaline were studied on the progesterone production of rat and human corpora lutea and compared to hCG-induced hormone production. Human corpora lutea were obtained from healthy patients, rat corpora lutea were harvested on day 6 of pseudopregnancy. Corpora lutea were digested by trypsin and homogeneous luteal cell suspension (6 × 10⁵ cells/ml) was incubated for 2 h. Hexoprenaline and hCG were added to the medium and progesterone production was measured by RIA. Hexoprenaline or hCG dose-dependently increased the progesterone production of rat luteal cells and of human cells in mid- and late luteal phase. Moreover, hexoprenaline further increased the hCG-induced hormone production. The stimulatory effect of hexoprenaline could be prevented by propranolol. It is supposed that Β₂-adrenergic stimulation induces an increase in progesterone production of luteal cells and potentiates the effects of gonadotropic hormones.

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STIMULATION BY Β2-Adrenergic RECEPTORS OF THE PRODUCTION OF CYCLIC AMP AND PROGESTERONE IN RAT OVARIAN TISSUE

Cited by 37 publications

References 13 publications

Role of the central and peripheral nervous system in the ovarian function

Role of the central and peripheral nervous system in the ovarian function

Norepinephrine Amplifies Human Chorionic Gonadotropin-Stimulated Androgen Biosynthesis by Ovarian Theca-Interstitial Cells*

Increase of Progesterone Production in Human and Rat Luteal Cells by Beta-Adrenergic Stimulation

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