Abstract:Tracheal antimicrobial peptide (TAP) is a β-defensin with microbicidal activity against bacterial pathogens causing bovine respiratory disease. Lipopolysaccharide stimulates TAP gene expression, with maximal effect after 16 hours of stimulation. This study investigated other agonists of TAP gene expression to enhance immunity in calves during times of increased disease risk. Unstimulated bovine tracheal epithelial cells grown in culture expressed mRNA for IL-17RA and Toll-like receptors (TLR) 1-6 and 9. These … Show more
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