Stimulating both eyes with matching stimuli enhances V1 responses

Mitchell, Blake; Dougherty, Kacie; Westerberg, Jacob A.; Carlson, Brock M.; Daumail, Loïc; Maier, Alexander; Cox, Michele A.

doi:10.1016/j.isci.2022.104182

Cited by 10 publications

(13 citation statements)

References 90 publications

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“…As shown in Fig. 4A, the median of binocular neuronal responses is slightly higher than that of monocular responses of either eye (black vs. red/blue arrows), consistent with earlier reports (Prince et al, 2002; Mitchell et al, 2022). However, individually, compared to monocular responses, responses of monocular neurons more preferring the stimulated eye are actually suppressed, and only responses of binocular neurons are increased by binocular stimulation.…”

Section: Discussionsupporting

confidence: 92%

“…Relevant to this issue, Fig. 4A shows that the median of binocular neuronal responses is only slightly higher than that of monocular responses of either eye (black vs. red/blue arrows), consistent with earlier reports (Prince et al, 2002; Mitchell et al, 2022). The overall similar monocular and binocular responses may account for a large proportion of the stable vision under both viewing conditions.…”

Section: Discussionsupporting

confidence: 90%

“…Previous neurophysiological recording studies have revealed that overall the binocular responses of macaque V1 neurons are lower than the sum of monocular responses to each eye (Prince et al, 2002;Mitchell et al, 2022), but are stronger than monocular responses either when one eye was stimulated (Prince et al, 2002;Mitchell et al, 2022), or when neurons' preferred eye was stimulated (Mitchell et al, 2022). Further, there is evidence that neurons' eye preference may have important functional roles.…”

Section: Introductionmentioning

confidence: 97%

“…It has been reported that overall the binocular responses of macaque V1 neurons are lower than the sum of monocular responses to each eye (Prince et al, 2002; Mitchell et al, 2022), but are stronger than monocular responses either when one eye was stimulated (Prince et al, 2002; Mitchell et al, 2022), or when neurons’ preferred eye was stimulated (Mitchell et al, 2022). Further, Dougherty et al (2019) reported that the responses of monocular neurons are found to be more likely suppressed than facilitated by binocular stimulation.…”

Section: Introductionmentioning

confidence: 99%

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Ocular dominance-dependent binocular combination of monocular neuronal responses in macaque V1

Zhang,

Zhao,

Tang

et al. 2023

Preprint

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Primates rely on two eyes to see depth, while keeping a stable vision when one eye is closed. Although psychophysical and modeling studies have investigated how monocular signals are combined to form binocular vision, the corresponding neuronal mechanisms, especially in V1 where most neurons become binocular but with different eye preferences, are not well understood. Here we used two-photon calcium imaging to compare monocular and binocular responses of thousands of V1 superficial-layer neurons in three awake macaques. Under monocular stimulation, neurons preferring the stimulated eye responded substantially stronger than those preferring both eyes. However, under binocular stimulation, the responses of neurons preferring either eye were suppressed, and those preferring both eyes were enhanced, so that neuronal responses became similar regardless of eye preferences. A neuronally realistic model of binocular combination, which includes ocular dominance-dependent divisive interocular inhibition, and binocular summation, is proposed to account for these observations.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ocular dominance-dependent binocular combination of monocular neuronal responses in macaque V1

Zhang,

Zhao,

Tang

et al. 2023

Preprint

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“…Different involvement of parallel pathways in binocular rivalry could be also due to their differences in the neural circuitry of binocular interactions. Recent studies show that binocular facilitation occurs at low contrast level (M-biased) and at an early stage of visual processing, while binocular suppression occurs at high contrast level (P-biased) and at a later stage (K Dougherty et al, 2019; Mitchell et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Hierarchical and fine-scale mechanisms of binocular rivalry for conscious perception

Cui

Chen

Hollander

et al. 2023

Preprint

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Conscious perception alternates between the two eyes' images during binocular rivalry. How hierarchical processes in our brain interact to resolve visual competition remains unclear. Here we investigated mesoscale neural circuitry of binocular rivalry in human cortical and subcortical areas using high-resolution functional MRI at 7 Tesla. Eye-specific rivalry modulation was strongest in the superficial layers of V1 ocular dominance columns (ODCs), and more synchronized in the superficial and deep layers. The intraparietal sulcus (IPS) generated stronger eye-specific modulation and increased feedback connectivity to the early visual cortex during binocular rivalry compared to stimulus replay. Although there was no evidence of eye-specific rivalry modulation in the lateral geniculate nucleus (LGN) of the thalamus, strong perceptual rivalry modulation can be found in its parvocellular (P) subdivision. Finally, IPS and ventral pulvinar showed robust perceptual rivalry modulation and increased connectivity to the early visual cortex. These findings demonstrate that local interocular competition arises from lateral mutual inhibition between V1 ODCs, and feedback signals from IPS to visual cortex and visual thalamus further resolve and synchronize visual competitions to generate conscious perception.

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