2010
DOI: 10.1016/j.vetimm.2009.11.004
|View full text |Cite
|
Sign up to set email alerts
|

Stimulated expression of TNF-α and IL-8, but not of lingual antimicrobial peptide reflects the concentration of pathogens contacting bovine mammary epithelial cells

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
44
1

Year Published

2010
2010
2023
2023

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 45 publications
(47 citation statements)
references
References 26 publications
2
44
1
Order By: Relevance
“…We note that the induction kinetics for these factors are grossly different between both studies. We observed a strong downregulation of the mRNA concentration for all these cytokines, commencing 1 to 3 h p.i., as has often been found (17,26,49,58) but which was not recorded in the that study (15). We cannot conclusively reconcile these differences.…”
Section: Vol 79 2011 Kinetics Of Pathogen-specific Immune Response contrasting
confidence: 62%
See 3 more Smart Citations
“…We note that the induction kinetics for these factors are grossly different between both studies. We observed a strong downregulation of the mRNA concentration for all these cytokines, commencing 1 to 3 h p.i., as has often been found (17,26,49,58) but which was not recorded in the that study (15). We cannot conclusively reconcile these differences.…”
Section: Vol 79 2011 Kinetics Of Pathogen-specific Immune Response contrasting
confidence: 62%
“…Also, the induction of this gene is retarded compared to that with the E. coli stimulation. Conceivably, increasing the challenge dose might speed up the induction of IL-6 expression, following our own experiences regarding the dosage-dependent kinetics of cytokine expression in this cell system (17). However, increasing the challenge intensity would conceivably also accelerate the induction kinetics subsequent to the E. coli stimulus.…”
Section: Discussionmentioning
confidence: 88%
See 2 more Smart Citations
“…Sensing the pathogen and initiating an immune response depends on the initial number of bacteria present at the start of the IMI. Increase the initial challenge dose of E. coli resulted in faster immune response in primiparous cows (Vangroenweghe et al, 2004;Schukken et al, 2011), which the extend of induced cytokines synthesis, such as TNF-α and IL-8, in mammary epithelial cells positively correlated with the concentration of E. coli particles (Guntler et al, 2010). Congruently, expression of IL-8 and Interferon (IFN)-γ by milk somatic cells was increased in E. coli challenged mammary glands .…”
Section: Mastitis Caused By Escherichia Colimentioning
confidence: 98%