Stimulant laxatives for constipation and soiling in children

Evaluation and Treatment of Functional Constipation in Infants and Children

“…The search identified 252 studies including 5 systematic reviews (9,56,(70)(71)(72). Among the 5 systematic reviews, the review of Price et al (70) did not include any drug trial. Lee-Robichaud et al (71) performed a review to determine whether lactulose or polyethylene glycol (PEG) was more effective in treating chronic constipation and fecal impaction in adults and children.…”

“…The search identified 252 studies including 5 systematic reviews (9,56,(70)(71)(72). Among the 5 systematic reviews, the review of Price et al (70) did not include any drug trial.…”

Evaluation and Treatment of Functional Constipation in Infants and Children

“…The search identified 252 studies including 5 systematic reviews (9,56,(70)(71)(72). Among the 5 systematic reviews, the review of Price et al (70) did not include any drug trial. Lee-Robichaud et al (71) performed a review to determine whether lactulose or polyethylene glycol (PEG) was more effective in treating chronic constipation and fecal impaction in adults and children.…”

“…The search identified 252 studies including 5 systematic reviews (9,56,(70)(71)(72). Among the 5 systematic reviews, the review of Price et al (70) did not include any drug trial.…”

The ten “hard” questions in pediatric functional constipation

“…The stimulant laxatives mainly used in pediatric clinical practice are sennosides, bisacodyl and sodium picosulfate. Although controlled trials on the use of these agents for constipation in children are still lacking [ 82 ], extensive clinical experience and expert opinion-based guidelines support their use as second-line treatment options. Due to the paucity of well-designed data in children on the efficacy and tolerability of the long-term use, children refractory to PEG therapy should be referred for the treatment to a specialized unit of pediatric GI [ 52 ] Table 3 shows the recommended dosages of most frequently used oral and rectal laxatives.…”

Behavioural and cognitive interventions with or without other treatments for the management of faecal incontinence in children

“…Cochrane Database of Systematic Reviews behavioural interventions. A recent Cochrane review on "Stimulant laxatives for constipation and soiling in children"(Price 2001) failed to identify any suitable randomised controlled trial in the existing literature demonstrating the lack of evidence to guide the use of stimulant laxatives as well as the urgent need for further research in this subject.…”

Evaluation and Treatment of Functional Constipation in Infants and Children

“…The search identified 252 studies including 5 systematic reviews (9,56,(70)(71)(72). Among the 5 systematic reviews, the review of Price et al (70) did not include any drug trial. Lee-Robichaud et al (71) performed a review to determine whether lactulose or polyethylene glycol (PEG) was more effective in treating chronic constipation and fecal impaction in adults and children.…”

“…The search identified 252 studies including 5 systematic reviews (9,56,(70)(71)(72). Among the 5 systematic reviews, the review of Price et al (70) did not include any drug trial.…”

The ten “hard” questions in pediatric functional constipation

“…The stimulant laxatives mainly used in pediatric clinical practice are sennosides, bisacodyl and sodium picosulfate. Although controlled trials on the use of these agents for constipation in children are still lacking [ 82 ], extensive clinical experience and expert opinion-based guidelines support their use as second-line treatment options. Due to the paucity of well-designed data in children on the efficacy and tolerability of the long-term use, children refractory to PEG therapy should be referred for the treatment to a specialized unit of pediatric GI [ 52 ] Table 3 shows the recommended dosages of most frequently used oral and rectal laxatives.…”

Behavioural and cognitive interventions with or without other treatments for the management of faecal incontinence in children

“…Cochrane Database of Systematic Reviews behavioural interventions. A recent Cochrane review on "Stimulant laxatives for constipation and soiling in children"(Price 2001) failed to identify any suitable randomised controlled trial in the existing literature demonstrating the lack of evidence to guide the use of stimulant laxatives as well as the urgent need for further research in this subject.…”

Evaluation and Treatment of Functional Constipation in Infants and Children

“…The search identified 252 studies including 5 systematic reviews (9,56,(70)(71)(72). Among the 5 systematic reviews, the review of Price et al (70) did not include any drug trial. Lee-Robichaud et al (71) performed a review to determine whether lactulose or polyethylene glycol (PEG) was more effective in treating chronic constipation and fecal impaction in adults and children.…”

“…The search identified 252 studies including 5 systematic reviews (9,56,(70)(71)(72). Among the 5 systematic reviews, the review of Price et al (70) did not include any drug trial.…”

The ten “hard” questions in pediatric functional constipation

“…The stimulant laxatives mainly used in pediatric clinical practice are sennosides, bisacodyl and sodium picosulfate. Although controlled trials on the use of these agents for constipation in children are still lacking [ 82 ], extensive clinical experience and expert opinion-based guidelines support their use as second-line treatment options. Due to the paucity of well-designed data in children on the efficacy and tolerability of the long-term use, children refractory to PEG therapy should be referred for the treatment to a specialized unit of pediatric GI [ 52 ] Table 3 shows the recommended dosages of most frequently used oral and rectal laxatives.…”

Behavioural and cognitive interventions with or without other treatments for the management of faecal incontinence in children

“…Cochrane Database of Systematic Reviews behavioural interventions. A recent Cochrane review on "Stimulant laxatives for constipation and soiling in children"(Price 2001) failed to identify any suitable randomised controlled trial in the existing literature demonstrating the lack of evidence to guide the use of stimulant laxatives as well as the urgent need for further research in this subject.…”