Stillbirths in Macaca fascicularis

Sesbuppha, Wacharaporn; Chantip, Surachai; Dick, Edward J.; Schlabritz‐Loutsevitch, Natalia; Guardado-Mendoza, Rodolfo; Butler, Stephanie D.; Frost, Patrice A.; Hubbard, Gene B.

doi:10.1111/j.1600-0684.2007.00275.x

Cited by 19 publications

(18 citation statements)

References 15 publications

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“…describe features like early presence of intravascular trophoblast, superficial implantation and absence of decidual reaction in Old World NHP as compared to humans (12, 16, 17). Data describing premature placental separation in NHP is limited to a few cases of both experimental and spontaneous abruption (18–25). There are no published data available in any NHP regarding the incidence of placental abruption.…”

Section: Introductionmentioning

confidence: 99%

Abruptio placentae in the baboon (Papio spp.)

Schenone

Schlabritz‐Loutsevitch

Zhang

et al. 2012

Placenta

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Introduction Placental abruption is a serious condition that increases perinatal morbidity and mortality. Clinical prevention and treatment options are limited, especially in human preterm deliveries. Knowledge of the mechanisms that keep the placenta in place during pregnancy is critical for developing strategies for the prevention of abruption. Failure of physiological transformation of spiral arteries has been described as a major contributing factor of the placental abruption development. Baboons (Papio spp.) share striking similarities with humans in regard to placental structure, utero-placental blood flow, and fetal development; however, the mode of trophoblast invasion is shallow in baboons. This fact prompted the hypothesis that the incidence of placental abruption will be increased in baboons compared to humans. Material and methods Baboon placentas were collected between 2002 and 2008. Two independent veterinary pathologists evaluated the slides. A certified physician pathologist performed additional histology. Results Placental abruption was diagnosed in 22 baboons among 2,423 live births during the study period (0.9% prevalence). The most common clinical presentations were fetal demise and vaginal bleeding. The most common pathological findings were intraplacental hemorrhage with or without hematoma formation (86.4%). Other findings consisted of neutrophil infiltration (50%), decidual necrosis (22.7%), decidual vascular congestion and inflammation, villous congestion and retroplacental hemorrhage/hematoma (18.2%). These pathologic findings were the same for term and preterm deliveries. Conclusion This is the first systematic study of placental abruption in non-human primates, analyzing a large colony of baboons. Despite differences in trophoblast invasion, the clinical features observed in placental abruption affecting baboons resembled those reported in humans. The cluster of placental pathological findings in baboons also agreed with clinical reports, but the prevalence of these findings differed between baboons and humans. We discuss a mechanism of anti-abruption forces that offset shallow trophoblast invasion observed in baboons.

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Section: Introductionmentioning

confidence: 99%

Abruptio placentae in the baboon (Papio spp.)

Schenone

Schlabritz‐Loutsevitch

Zhang

et al. 2012

Placenta

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“…Despite the fact that the natural occurrence of such pregnancy-related complications as stillbirths and placenta abruption cases in Old World NHP (baboons and macaques) are similar to humans [26,27,28], the differences between NHP and humans including shallow trophoblast invasion, decreased amount of amniotic fluid in the third trimester, the mechanism of labor [13], and myometrial thickness [27], might be the reason behind the reported increased complication rate and technical difficulties in NHP. Interestingly, van der Wildt et al [25] found the absence of myometrial electrical activity in rhesus monkeys after simple fetoscopic manipulations.…”

Section: Discussionmentioning

confidence: 99%

“…In this case, the surgery was performed at 163 dGA (it was a second surgery in the S-FETO group). This gestational age is defined as ‘at term' in baboons [28]. The animal was close to delivery as indicated by vaginal discharge, position of fetal head and cervical opening at the ultrasound evaluation.…”

Section: Discussionmentioning

confidence: 99%

A Novel Translational Model of Percutaneous Fetoscopic Endoluminal Tracheal Occlusion - Baboons (Papio spp.)

et al. 2014

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Introduction: Percutaneous fetoscopic endoluminal reversible tracheal occlusion (FETO) was developed to prevent the pulmonary complications of fetal congenital diaphragmatic herniation. There is an urgent need to establish the closest to human translational model of FETO in order to improve fetal outcomes and to determine new clinical approaches and applications. Material and Methods: Seven non-human primates underwent two subsequent surgeries: the first, the FETO in the experimental group (n = 3) or sham operation in the control animals (S-FETO, n = 4) at 132-142 days of gestation (dGA); the second, the reversal of occlusion or sham operation at 162 ± 5 dGA. Maternal stress axis, complete blood count, and biochemical parameters were evaluated and newborn tracheal radiography was performed. Results: The average pregnancy duration and neonatal weights in the FETO group did not differ from the animals in the S-FETO group. There was no bleeding or premature fetal membrane rupture during the procedures in any of the baboons. The maximal tracheal width was 7.02 ± 0.6 mm in the FETO versus 5.46 ± 0.6 mm in S-FETO group. Discussion: This is the very first report of a successful FETO model in non-human primates. Similarities to human tracheomegaly were for the first time documented in any model studied.

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“…The overall stillbirth rate is 12-22% in cynomolgus monkeys [55,56]. Infant losses in the first month after delivery range from 12% to 22%, with the possibility of a similar amount of additional infant loss during the first year postpartum [54,56].…”

Section: Developmental Toxicity Studiesmentioning

confidence: 99%