Stillbirth: Case definition and guidelines for data collection, analysis, and presentation of maternal immunization safety data

Silva, Fernanda Tavares Da; Gonik, Bernard; McMillan, Mark; Keech, Cheryl; Dellicour, Stephanie; Bhange, Shraddha; Tila, Mihaela; Harper, Diana M.; Woods, Charles R.; Kawai, Alison Tse; Kochhar, Sonali; Muñoz, Flor M.

doi:10.1016/j.vaccine.2016.03.044

Cited by 143 publications

(105 citation statements)

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“…There were insufficient numbers to study spontaneous abortion (defined as pregnancies with gestational length <22 weeks or birthweight <500 g) as a separate outcome (Da Silva et al, 2016). In addition, we excluded births from the referent cohort where the mother had been identified as being at-risk of having an ED in HUNT3.…”

Section: Methodsmentioning

confidence: 99%

Impact of eating disorders on obstetric outcomes in a large clinical sample: A comparison with the HUNT study

Eik‐Nes

Horn

Strohmaier

et al. 2018

Intl J Eating Disorders

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Section: Methodsmentioning

confidence: 99%

Impact of eating disorders on obstetric outcomes in a large clinical sample: A comparison with the HUNT study

Eik‐Nes

Horn

Strohmaier

et al. 2018

Intl J Eating Disorders

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“…18 Twentyone standardized case definitions for obstetric outcomes and neonatal outcomes were developed and standardized case definitions for preterm birth, stillbirth, congenital abnormalities, spontaneous abortion, small for gestational age and low birth weight have been published. [19][20][21][22][23][24] Preterm birth (PTB)…”

Section: Definitions Related To Outcomes Of Interestmentioning

confidence: 99%

The safety of inactivated influenza vaccines in pregnancy for birth outcomes: a systematic review

Giles

Krishnaswamy

Macartney

et al. 2018

Human Vaccines & Immunotherapeutics

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Pregnant women are at increased risk of morbidity and mortality from influenza and are recognized as a priority group for influenza vaccination. Despite this, uptake is often poor and one reason cited for this is concerns about safety. The objective of this study was to perform a systematic review of the safety of inactivated influenza vaccination (IIV) in pregnancy. Studies were included if they were: (i) observational or experimental design; (ii) included a comparator group comprising of unvaccinated pregnant women; (iii) comprised of either seasonal IIV or monovalent H1N1 IIV (including adjuvanted vaccines); and (iv) addressed one of the following outcomes: preterm birth (PTB), small for gestational age (SGA), fetal death (including stillbirth or spontaneous abortion), low birth weight (LBW) or congenital abnormalities. Two reviewers screened abstracts and titles and selected full texts for retrieval. Crude odds ratios were calculated from reported event rates, using binomial standard errors. Adjusted odds ratios, hazard ratios and relative rates were extracted as reported in each paper. After removal of duplicates and full text eligibility assessment, 40 studies remained. The aOR for PTB was 0.87 (0.78-0.96), for LBW 0.82 (0.76-0.89), congenital abnormality 1.03 (0.99-1.07), SGA 0.99 (0.94-1.04) and stillbirth 0.84 (0.65-1.08). This study contributes to the increasing body of safety data for IIV in pregnancy and reports a protective effect on PTB and LBW.

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“…Stillbirth is defined as the delivery of a fetus born with no signs of life. However, the definition varies across countries by gestational age and birthweight, which complicates international comparisons [11]. Georgian national guidelines define stillbirth as a fetus born with no sign of life at 22 completed gestational weeks or more, or a birthweight of >500 g, if the gestational age is unknown.…”

Section: Introductionmentioning

confidence: 99%

“…In areas with low healthcare service coverage, the main causes of PM are asphyxia, neonatal tetanus, and infections [13]. Comparing specific causes of stillbirth is a challenge as a universal worldwide classification of causes of stillbirth is missing [11,14,15].…”

Section: Introductionmentioning

confidence: 99%

Incidence and Causes of Perinatal Mortality in Georgia

Manjavidze¹,

Rylander²,

Skjeldestad³

et al. 2019

JEGH

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KeywordsBirth registry perinatal mortality stillbirth early neonatal death cause of death A B S T R A C TGeorgia has one of the highest perinatal mortality rates (i.e., stillbirths and early neonatal deaths combined) in Europe. The Georgian Birth Registry was started in 2016 to provide data for preventive measures of maternal and child health. In this study, we aim to determine the incidence of perinatal mortality, assess the distribution of stillbirths and early neonatal deaths, and to determine the major causes of perinatal mortality in Georgia. Data sources were the Georgian Birth Registry and the vital registration system for the year 2017. Causes of early neonatal deaths were assigned into five categories, using the Wigglesworth classification with the Neonatal and Intrauterine deaths Classification according to Etiology modification. The study used descriptive statistics only, specifically counts, means, proportions, and rates, using the statistical software STATA version 15.0 (StataCorp, College Station, TX, USA). In 2017, 489 stillbirths and 238 early neonatal deaths were recorded, resulting in a perinatal mortality rate of 13.6 per 1000 births. About 80% of stillbirths had an unknown cause of death. The majority of stillbirths occurred before the start of labor (85%), and almost one-third were delivered by caesarean section (28%). Prematurity (58%) and congenital malformations (23%) were the main causes of early neonatal deaths, and 70% of early neonatal deaths occurred after the first day of life. The perinatal mortality rate in Georgia remained high in 2017. The major causes of early neonatal deaths were comparable to those of many high-income countries. Contrary to global data, most early neonatal deaths occurred after the first day of life.

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Stillbirth: Case definition and guidelines for data collection, analysis, and presentation of maternal immunization safety data

Cited by 143 publications

References 100 publications

Impact of eating disorders on obstetric outcomes in a large clinical sample: A comparison with the HUNT study

Impact of eating disorders on obstetric outcomes in a large clinical sample: A comparison with the HUNT study

The safety of inactivated influenza vaccines in pregnancy for birth outcomes: a systematic review

Incidence and Causes of Perinatal Mortality in Georgia

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