Still Fighting for Breath: a patient survey of the challenges and impact of severe asthma

Κatsaounou, Paraskevi; Odemyr, Mikaëla; Spranger, O.; Hyland, Michael E.; Kroegel, Claus; Conde, Lorena Garcia; Gore, Robin; Menzella, Francesco; Ribas, Christian; Morais‐Almeida, Mário; Gasser, Μatthias; Kasujee, Ismail

doi:10.1183/23120541.00076-2018

Cited by 24 publications

(27 citation statements)

References 31 publications

(31 reference statements)

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“…Stomach pain was reported by 20% of the asthma patients weekly, compared with 79% for IBS. The levels of depression (36%) and anxiety (45%) are comparable with those of an international survey of severe asthma …”

Section: Discussionsupporting

confidence: 63%

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Evidence for similarity in symptoms and mechanism: The extra‐pulmonary symptoms of severe asthma and the polysymptomatic presentation of fibromyalgia

Hyland

Lanario

Wei

et al. 2019

Immunity Inflam & Disease

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BackgroundAsthma is a disease of the lung and a systemic disease. Functional disorders are associated with multiple systemic abnormalities that have been explained by complexity models. The aim was to test the similarity in type and aetiology between the extra‐pulmonary symptoms of severe asthma and the symptoms of fibromyalgia.MethodsOne Hundred patients recruited from a specialist severe asthma clinic and 1751 people reporting different functional disorder diagnoses recruited via the internet completed the same 60‐item questionnaire. Symptom patterns were compared between groups using a new measure, the symptom pattern similarity index where 0 = no relationship, 1 = identical patterns between groups.ResultsSevere asthma patients report numerous extra‐pulmonary symptoms. The similarity index between the symptom pattern of the asthma patients with other groups was irritable bowel syndrome = 0.54, chronic fatigue syndrome = 0.69, and fibromyalgia = 0.75. The index between fibromyalgia and asthma patients with the most and least frequent extra‐pulmonary symptoms was 0.81 and 0.55 respectively.ConclusionsPatients with severe asthma have numerous extra‐pulmonary symptoms similar in type and pattern to the symptoms of fibromyalgia. The similarity of the symptom pattern between asthma and fibromyalgia increases as the number of extra‐pulmonary symptoms increases as predicted by network theory and previously shown to be the case with other functional disorders. These findings support the hypothesis that functional disorders and extra‐pulmonary asthma symptoms have a common complexity or network aetiology. Evidence based behavioural interventions for fibromyalgia may be helpful for patients with severe asthma reporting extra‐pulmonary symptoms.

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Section: Discussionsupporting

confidence: 63%

“…The levels of depression (36%) and anxiety (45%) are comparable with those of an international survey of severe asthma. 35 Similarity in symptoms between two groups does not mean similarity of cause. Irritability is a symptom of all four groups but is also a side effect of oral corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Evidence for similarity in symptoms and mechanism: The extra‐pulmonary symptoms of severe asthma and the polysymptomatic presentation of fibromyalgia

Hyland

Lanario

Wei

et al. 2019

Immunity Inflam & Disease

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“…Европейская федерация аллергии и Ассоциация пациентов с болезнями дыхательных путей В настоящее время нет сомнений в необходимости вовлечения пациентов в процесс лечения; уже были достигнуты определенные успехи в продвижении и организации самопомощи при заболевании (http:// www.efanet.org/annual-report/2017; http://www.efanet. org/resources/library/3296-severely-asthma-project) [16,17]. Однако прогресс в этом направлении неоднозначен: финансирование распределяется неравномерно, недостаточно средств для проведения мероприятий для профилактики аллергических болезней и бронхиальной астмы, нет скооординированных профилактических рекомендаций для пациентов.…”

Section: всемирная организация здравоохраненияunclassified

Prioritizing Research Challenges and Funding for Allergy and Asthma and the Need for Translational Research — The European Strategic Forum on Allergic Diseases

et al. 2020

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The European Academy of Allergy and Clinical Immunology (EAACI) organized the first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring together all relevant stakeholders and decision‐makers in the field of allergy, asthma and clinical Immunology around an open debate on contemporary challenges and potential solutions for the next decade. The Strategic Forum was an upscaling of the EAACI White Paper aiming to integrate the Academy’s output with the perspective offered by EAACI’s partners. This collaboration is fundamental for adapting and integrating allergy and asthma care into the context of real‐world problems. The Strategic Forum on Allergic Diseases brought together all partners who have the drive and the influence to make positive change: national and international societies, patients’ organizations, regulatory bodies and industry representatives. An open debate with a special focus on drug development and biomedical engineering, big data and information technology and allergic diseases and asthma in the context of environmental health concluded that connecting science with the transformation of care and a joint agreement between all partners on priorities and needs are essential to ensure a better management of allergic diseases and asthma in the advent of precision medicine together with global access to innovative and affordable diagnostics and therapeutics.

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“…Adult patients (>18 years) and caregivers of pediatric and adolescent patients (6-17 years) from nine countries were enrolled in this survey. Patients invited to complete the screening questionnaire were mainly identifi ed via databases (consumer panels) [63].…”

Section: Participantsmentioning

confidence: 99%

“…Here, we present fi ndings from the Still Fighting for Breath II global survey [63], regarding the prevalence of smoking in patients with severe asthma, impact of smoking on asthma control and correlation of smoking with different aspects of QoL in patients with severe persistent asthma.…”

Section: Introductionmentioning

confidence: 99%

Smoking asthmatics, a neglected large phenotype of asthmatic patients

Κatsaounou¹,

Ioannou²,

Hyland³

et al. 2019

Open J Asthma

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Introduction: Smoking in asthma patients is an important factor contributing to worsened control of asthma. Despite increased awareness of the harmful effects of smoking in patients with asthma, a signifi cant proportion of asthmatics remain smokers. Here, we present fi ndings from the Still Fighting for Breath global survey regarding the prevalence of smoking in patients with severe asthma, impact of smoking on asthma control and correlation of smoking with different aspects of quality of life in patients with severe persistent asthma. Methods: This online survey conducted by GfK Switzerland in 2016 collected data from 1333 adults (>18 years) and caregivers of children (6-17 years) with severe persistent asthma in 9 countries. Results: Our results showed that smoking was common in asthma patients with 46% of adult patients either current smoker (20%), ex-smoker (24%) or e-cigarette smokers (2%).The proportion of patients with asthma who were current smokers/ ex-smokers or e-cigarette smokers was higher than in the general population in many countries. Overall, 63% of adult patients avoided smoky premises; however, 20% of adults were active smokers .Current smokers with asthma were signifi cantly more frequently diagnosed with anxiety (47%) and depression (41%) than non-smokers (40% and 27%, respectively) and ex-smokers (42% and 28%, respectively). A positive correlation was observed between the number of days that patients with severe asthma used OCS and asthma control according to both the Global Initiative for Asthma (GINA)defi ned control (Spearman's rho=0.24, P<0.001) and patient-perceived control (Spearman's rho=0.13, P< 0.001). Conclusion: This survey shows a high prevalence of smoking in patients with severe persistent asthma. Smoking was associated with increased risk of anxiety/depression and show slight increase in use of oral corticosteroid in these patients. These highlight the need for improved strategies for better management of the disease in smokers with severe persistent asthma.

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Still Fighting for Breath: a patient survey of the challenges and impact of severe asthma

Cited by 24 publications

References 31 publications

Evidence for similarity in symptoms and mechanism: The extra‐pulmonary symptoms of severe asthma and the polysymptomatic presentation of fibromyalgia

Evidence for similarity in symptoms and mechanism: The extra‐pulmonary symptoms of severe asthma and the polysymptomatic presentation of fibromyalgia

Prioritizing Research Challenges and Funding for Allergy and Asthma and the Need for Translational Research — The European Strategic Forum on Allergic Diseases

Smoking asthmatics, a neglected large phenotype of asthmatic patients

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