Stilbenes: Chemistry and Molecular Mechanisms of Anti-obesity

Chou, Ya-Chun; Ho, Chi‐Tang; Pan, Min‐Hsiung

doi:10.1007/s40495-018-0134-5

Cited by 18 publications

(7 citation statements)

References 47 publications

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“…Stilbenes are organic compounds that have a compact structure with a central ethylene fraction and one phenyl group. The phenyl group is located at the ends of the carbon double bonds (Chou et al, 2018) [39] . The common name for stilbenes is Tran's stilbenes.…”

Section: Stilbenesmentioning

confidence: 99%

Classifications of polyphenols and their potential application in human health and diseases

Prabhu¹,

Molath²,

Choksi³

et al. 2021

Int. J. Physiol. Nutr. Phys. Educ.

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Polyphenols are naturally occurring organic compounds composed of several phenols' units. The polyphenols are the secondary metabolites produced by the plants which played an imperative role in industrial and therapeutic applications. The polyphenols are composed of the phenolic ring and structural element that bind these phenolic rings to one another. The polyphenols were categorized under different sub-categories according to their nature of action and their structural components. Different polyphenols were categorized under phenolics acids, flavonoids, stilbenes, lignans and other polyphenols together with xanthones, tannins and anthraquinones. Fruits, vegetables, cereals, legumes, herbs and spices are the prime source of polyphenols. The composition of these polyphenols is significantly altered by internal and external conditions like agro-climatic conditions, harvesting time, cultivation, origin and so on. Polyphenols represent pharmaconutrients that can be utilized in the manufacturing of drugs, functional foods, coloring and other human health supplements. With the advancement of scientific knowledge these polyphenols isolated from their natural source via different emerging techniques like ultra-highpressure extractions, supercritical fluid extraction, ultrasonic and heat reflux. Data from the clinical trials, In-Virto/Vivo, placebo-control, randomized and animals' trials suggest that the polyphenols have the potential in the pre-treatment or prevention of numerous chronic ailments including cardiovascular (CVD), degenerative diseases, neurodegenerative diseases, Parkinson's and Alzheimer's and other immune-related disorder.

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Section: Stilbenesmentioning

confidence: 99%

Classifications of polyphenols and their potential application in human health and diseases

Prabhu¹,

Molath²,

Choksi³

et al. 2021

Int. J. Physiol. Nutr. Phys. Educ.

View full text Add to dashboard Cite

show abstract

“…Similar to flavonoids, stilbenes are synthesized to defense plants against various environmental stresses such as wounding, fungal infection, UV radiation, etc. They are also important drug substances because of their anti-cancer, anti-inflammatory and anti-obesity activities [112, 113]. Well-known stilbenes produced by microbial systems are resveratrol, pterostilbene, piceatannol, pinosylvin, etc.…”

Section: Engineering the Biosynthesis Pathway Of Aromatic Amino Acidsmentioning

confidence: 99%

Metabolic engineering of microorganisms for production of aromatic compounds

2019

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Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non-food biomass. Even though microbial production of various chemicals has successfully been conducted and commercialized, there are still numerous chemicals and materials that await their efficient bio-based production. Aromatic chemicals, which are typically derived from benzene, toluene and xylene in petroleum industry, have been used in large amounts in various industries. Over the last three decades, many metabolically engineered microorganisms have been developed for the bio-based production of aromatic chemicals, many of which are derived from aromatic amino acid pathways. This review highlights the latest metabolic engineering strategies and tools applied to the biosynthesis of aromatic chemicals, many derived from shikimate and aromatic amino acids, including l -phenylalanine, l -tyrosine and l -tryptophan. It is expected that more and more engineered microorganisms capable of efficiently producing aromatic chemicals will be developed toward their industrial-scale production from renewable biomass.

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“…4',3,5tetrahydroxystilbene), commonly found in berries, grapes, rhubarb, and white tea, is very similar in structure to resveratrol, except for an additional hydroxyl group. Scirpusin B is one of the many possible dimeric structures of Piceatannol (Chou et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Pharmacokinetic Profile of Cirpusins®, Extract of Cyperus rotundus in Presence of Bioavailability Enhancer, BioPerine®

Majeed

Bani

Pandey

et al. 2023

JAB

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Obesity, a condition accompanying abnormal or excessive accumulation of fat in the body has become a major public health concern globally. Various herbs hailed from traditional systems of medicine like Ayurveda have gained importance in recent years to combat obesity. One such herb Cyperus rotundus (nutgrass), is known for its beneficial effects in obesity, in Ayurveda. Cirpusins® a patented extract from the dried rhizomes of Cyperus rotundus (standardized for minimum of 6% total identified stilbenes - Piceatannol, Scirpusin A & Scirpusin B) and BioPerine®, a bioavailability enhancer, obtained from the dried fruits of Piper nigrum (standardized to minimum 95% piperine). In this study, we examined the pharmacokinetic profile and bioavailability of Cirpusins® in Sprague-Dawley rats at two different doses (45 and 90 mg/kg) in the presence and absence of BioPerine® respectively. The results signifies that addition of BioPerine® (0.45 mg/kg) with Cirpusins® (45 mg/kg) enhances the bioavailability by reducing the effective dose of Cirpusins® (90 mg/kg) to half.

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Stilbenes: Chemistry and Molecular Mechanisms of Anti-obesity

Cited by 18 publications

References 47 publications

Classifications of polyphenols and their potential application in human health and diseases

Classifications of polyphenols and their potential application in human health and diseases

Metabolic engineering of microorganisms for production of aromatic compounds

Evaluation of Pharmacokinetic Profile of Cirpusins®, Extract of Cyperus rotundus in Presence of Bioavailability Enhancer, BioPerine®

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