Stilbenes and Their Derivatives in Traditional Medicine

Vijayan, Nimisha; Haridas, M.; Sabu, Abdulhameed

doi:10.1007/978-981-10-4284-3_17

Cited by 4 publications

(2 citation statements)

References 68 publications

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“…Stilbenes are naturally occurring non-flavonoid phenolics characterized by the presence of 1,2-diphenylethylene nuclei [85]. This group of phenolic compounds exerts a multifunctional impact on human health via modulation of antioxidant, anti-inflammatory, and cardioprotective cascade [86]. Resveratrol (3,4ʹ,5-trihydroxy-trans-stilbene) represents the most extensively studied stilbene which possesses a wide range of health-associated impacts, including antithrombotic and antiplatelet effects [87].…”

Section: Stilbenesmentioning

confidence: 99%

Antithrombotic and antiplatelet effects of plant-derived compounds: a great utility potential for primary, secondary, and tertiary care in the framework of 3P medicine

et al. 2022

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Thromboembolism is the third leading vascular disease, with a high annual incidence of 1 to 2 cases per 1000 individuals within the general population. The broader term venous thromboembolism generally refers to deep vein thrombosis, pulmonary embolism, and/or a combination of both. Therefore, thromboembolism can affect both – the central and peripheral veins. Arterial thromboembolism causes systemic ischemia by disturbing blood flow and oxygen supply to organs, tissues, and cells causing, therefore, apoptosis and/or necrosis in the affected tissues. Currently applied antithrombotic drugs used, e.g. to protect affected individuals against ischemic stroke, demonstrate significant limitations. For example, platelet inhibitors possess only moderate efficacy. On the other hand, thrombolytics and anticoagulants significantly increase hemorrhage. Contextually, new approaches are extensively under consideration to develop next-generation antithrombotics with improved efficacy and more personalized and targeted application. To this end, phytochemicals show potent antithrombotic efficacy demonstrated in numerous in vitro, ex vivo, and in vivo models as well as in clinical evaluations conducted on healthy individuals and persons at high risk of thrombotic events, such as pregnant women (primary care), cancer, and COVID-19-affected patients (secondary and tertiary care). Here, we hypothesized that specific antithrombotic and antiplatelet effects of plant-derived compounds might be of great clinical utility in primary, secondary, and tertiary care. To increase the efficacy, precise patient stratification based on predictive diagnostics is essential for targeted protection and treatments tailored to the person in the framework of 3P medicine. Contextually, this paper aims at critical review toward the involvement of specific classes of phytochemicals in antiplatelet and anticoagulation adapted to clinical needs. The paper exemplifies selected plant-derived drugs, plant extracts, and whole plant foods/herbs demonstrating their specific antithrombotic, antiplatelet, and fibrinolytic activities relevant for primary, secondary, and tertiary care. One of the examples considered is antithrombotic and antiplatelet protection specifically relevant for COVID-19-affected patient groups.

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Section: Stilbenesmentioning

confidence: 99%

Antithrombotic and antiplatelet effects of plant-derived compounds: a great utility potential for primary, secondary, and tertiary care in the framework of 3P medicine

et al. 2022

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“…Stilbenes, such as resveratrol, found in grapes and red wine, are known for their cardioprotective and anti-aging effects. Resveratrol in particular has garnered significant attention for its antioxidant, anti-inflammatory, and potential anticancer properties [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Baptista,

Paié-Ribeiro,

Almeida

et al. 2024

Molecules

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Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in six adults over 25. This review explores the potential of phenolic compounds in managing CKD and its complications. By examining the existing research, we highlight their diverse biological activities and potential to combat CKD-related issues. We analyze the nutritional benefits, bioavailability, and safety profile of these compounds. While the clinical evidence is promising, preclinical studies offer valuable insights into underlying mechanisms, optimal dosages, and potential side effects. Further research is crucial to validate the therapeutic efficacy of phenolic compounds for CKD. We advocate for continued exploration of their innovative applications in food, pharmaceuticals, and nutraceuticals. This review aims to catalyze the scientific community's efforts to leverage phenolic compounds against CKD-related challenges.

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Vegetable phytochemicals: An update on extraction and analysis techniques

Sharma

Kaushik

2021

Biocatalysis and Agricultural Biotechnology

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Stilbenes and Their Derivatives in Traditional Medicine

Cited by 4 publications

References 68 publications

Antithrombotic and antiplatelet effects of plant-derived compounds: a great utility potential for primary, secondary, and tertiary care in the framework of 3P medicine

Antithrombotic and antiplatelet effects of plant-derived compounds: a great utility potential for primary, secondary, and tertiary care in the framework of 3P medicine

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Vegetable phytochemicals: An update on extraction and analysis techniques

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