Stilbene Derivatives from <i>Cissus</i> <i>quadrangularis</i>

This review highlights why careful consideration of the biosynthetic origin (the how) and the biological function (the why) of a natural product can be so useful during the determination of its structure. Recent examples of structural reassignments inspired by biosynthetic and functional insights will be presented. This review will demonstrate the importance of viewing the origin, structure and function of a natural product as intertwined threads of a single story, best viewed as a whole rather than as discrete topics.

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“…natural products 21-24, see Fig. 5), [20][21][22][23] prompted Brill and Snyder to further investigate the structures of caraphenol B and C.…”

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confidence: 99%

The importance of asking “how and why?” in natural product structure elucidation

Brown

Lawrence

2017

Nat. Prod. Rep.

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“…[1] Several analogues of 1, compounds 2-6, have been obtained from other plants ( Scheme 1). [1,2] These molecules are all dimers or substituted dimers of resveratrol (7) with an indane skeleton. To date, no synthetic effort towards this family of compounds has been reported.…”

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confidence: 99%

Total Synthesis of (±)‐Quadrangularin A

Liu

et al. 2006

Angew Chem Int Ed

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“…Magano et al (2008) reported that the root extracts of S. italica subsp arachoides β-sitosterol, δ-amyrin, δ-amyrone, and flavonoids (quercetin) having different potential metabolic and physiological effects has also been reported to be present (Jainu and Devi, 2004;Jakikasem et al, 2000). There are also unique stilbene derivatives termed quadrangularins A, B and C (Adesanya et al, 1999). Phytochemical screening of the ethanolic extract of the stem of C. quadrangularis also revealed the presence of alkaloids, flavonoids, phenols and tannins in C. quadrangularis (Chidambara Murthy ).…”

Section: Discussionmentioning

confidence: 99%

Acaricidal activity of the organic extracts of thirteen South African plants against Rhipicephalus (Boophilus) decoloratus (Acari: Ixodidae)

Fouché

Ramafuthula

Maselela

et al. 2016

Veterinary Parasitology

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Highlights• The African blue tick, R. (B.) decoloratus, is found in Africa and Asia.• This tick affects cattle production as well as vector pathogens.• The extracts of two plants species have potent activity against R. (B.) decoloratus.• The extracts of these plants species have low toxicity against Vero cells. AbstractThe African blue tick, Rhipicephalus (Boophilus) decoloratus, is a common tick species found in South Africa and affects cattle production as well as vectoring pathogens in regions of Africa and Asia. In an attempt to develop a non-toxic, lower cost and environmentally friendly tick control method, twenty-six plant extracts were prepared from thirteen plant species using 99.5% acetone and 99% ethanol. The adapted Shaw Larval Immersion Test (SLIT) was used to test the efficacy of the extracts. A 1% solution of each of the plant extracts was prepared for efficacy testing and the ethanol extracts were found to have better acaricidal activity than the acetone extracts. The ethanol extract from the leaves and flowers of Calpurnia aurea had the best activity 2 [Corrected Mortality (CM) = 82.9%] which was followed by the stem extract of Cissus quadrangularis (CM = 80.4%). The plant species were screened against Vero cells and were found to have low toxicity. From this study it is apparent that there is potential for the development of botanicals as natural acaricides against R. (B.) decoloratus.

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Stilbene Derivatives from Cissus quadrangularis

Cited by 113 publications

References 6 publications

The importance of asking “how and why?” in natural product structure elucidation

The importance of asking “how and why?” in natural product structure elucidation

Total Synthesis of (±)‐Quadrangularin A

Acaricidal activity of the organic extracts of thirteen South African plants against Rhipicephalus (Boophilus) decoloratus (Acari: Ixodidae)

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