Polyphenylalkene derivatives Q 0740Stilbene-Based Inhibitors of Estrone Sulfatase with a Dual Mode of Action in Human Breast Cancer Cells. -A variety of sulfamoyloxy-substituted stilbenes such as (VII) and (VIII) with side chains that guarantee antiestrogenic activity are synthesized and evaluated as inhibitors of estrone sulfatase. Compound (VIIc), the most potent derivatives, inhibits the growth of wild-type human MCF-7 cells with an IC50 value of 13 nM. -(WALTER, G.; LIEBL, R.; VON ANGERER, E.; Arch. Pharm. (Weinheim, Ger.) 337 (2004) 12, 634-644; Inst. Pharm., Univ. Regensburg, D-93053 Regensburg, Germany; Eng.) -R. Langenstrassen 15-083