“…Recent studies have demonstrated that, among the CD4 T cells, a subset expressing CD25 has strong suppressor activity (Shevach, 2000, Suripayer et al, 1998. There is also evidence that some subsets of CD8 T cells are functionally suppressive (Sun et al, 1988b, Sun et al, 1999b, Jiang et al, 1992, Endharti et al, 2005, Najafian et al, 2003 (Bloom et al, 1992, Jiang et al, 1992, Rifa'i et al, 2004, Sun et al, 1999a. It is important to note that, during the late phases of chronic autoimmune diseases, CD8 autoreactive T cells accumulate in the damaged organ and in the periphery (Friese and Fugger, 2005, Bradl et al, 2005, Sun et al, 2001.…”