Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment

Cleavage and Noncleavage Chemistry in Reactive Oxygen Species (ROS)-Responsive Materials for Smart Drug Delivery

“…In another case, Cao's group developed an injectable ROS-sensitive cross-linked poly(vinyl alcohol) hydrogel which was used for marrow-derived macrophages. 156 Within the ROS-enriched periodontitis microenvironment, this PBA-based hydrogel responded by releasing mechano-stimulated macrophages. Simultaneously, the ROS-triggered response of the hydrogel worked to diminish ROS levels, suppressing periodontal inflammation and mitigating tissue damage.…”

Catechol-Modified and MnO2-Nanozyme-Reinforced Hydrogel with Improved Antioxidant and Antibacterial Capacity for Periodontitis Treatment

“…However, some flaws remain, such as patient intolerance, dental plaque recolonization, and a longer treatment period. The periodontal local drug delivery system (LDDS) is necessary to assist clinical treatment, which can retain certain amount of drug concentration and prevent recolonization of biofilms in periodontal pockets. , However, the overuse of antibiotics may cause the development of resistant strains of bacteria, and the time of drug remains in the periodontal pocket is too short to maintain effective drug concentration due to the complex environment in the oral cavity and the flushing effect of saliva. , In comparison, the hydrogel with a highly crosslinked structure has excellent encapsulating effect, allowing for long-term drug release . Besides, due to its biocompatibility and adhesiveness, the hydrogel has becoming an promising material for encapsulating drugs for periodontal delivery .…”

“…6,7 However, the overuse of antibiotics may cause the development of resistant strains of bacteria, and the time of drug remains in the periodontal pocket is too short to maintain effective drug concentration due to the complex environment in the oral cavity and the flushing effect of saliva. 8,9 In comparison, the hydrogel with a highly crosslinked structure has excellent encapsulating effect, allowing for long-term drug release. 10 Besides, due to its biocompatibility and adhesiveness, the hydrogel has becoming an promising material for encapsulating drugs for periodontal delivery.…”

Dual Glucose/ROS-Sensitive Injectable Adhesive Self-Healing Hydrogel with Photothermal Antibacterial Activity and Modulation of Macrophage Polarization for Infected Diabetic Wound Healing

“…Moreover, high-efficiency photothermal synergistic antibacterial TP@Ag NPs were prepared and dispersed into the hydrogel through phenylborate or imine reactions between catechol or quinone groups on TP@Ag NPs and phenylboronic acid in HAAPBA or amino group in GCHCA, respectively (Figure a–d). And the glucose/ROS responsive borate bond ,− in the hydrogel network could realize the responsive release of TP@Ag NPs, thereby promoting M2 polarization to achieve efficient anti-inflammatory effect, and the excess reactive oxygen could also be scavenged by the synergistic effect of catechol group and ROS-sensitive borate bond in the hydrogel. In addition, excellent biocompatibility and antioxidant performance were shown in the hydrogels.…”

“…Clinically, the healing of infected diabetic wound was usually hindered by a high concentration of glucose, so the glucose-responsive release of TP@Ag NPs from the HAAPBA/GVHCA/TP@Ag NPs hydrogel could show its superiority in use as dressings for promoting infected diabetic wound healing. It was reported − that dynamic phenylborate ester bonds would undergo cleavage under ROS stimulation, to achieve the ROS-sensitive drug release performance. And it could be seen that the accumulated release of TP@Ag NPs under ROS stimulation was approximately 10% more than that in PBS and lower than that under glucose stimulation.…”