Stiffness of tongue squamous cell carcinoma measured using strain elastography correlates with the amount of collagen fibers in the tumor

Shibata, Masami; Ishikawa, Ayataka; Ishii, Junichi; Anzai, Eri; Yagishita, Hisao; Izumo, Toshiyuki; Sumino, Jun; Katsurano, Miki; Kim, Yusoon; Kanda, Hiroaki; Ushijima, Masaru; Yagihara, Kazuhiro; Yoda, Tetsuya

doi:10.1007/s11282-021-00556-0

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…It recently has been shown that biomechanical properties of the tongue change at the onset of malignancies due to the synthesis and remodeling of collagen fibers, which indicates that tongue biomechanics evaluation may contribute to early diagnosis of tongue cancer. [ 19 , 20 ] Optical coherence elastography (OCE), as a functional extension of OCT, has a superior micrometer scale resolution and is therefore suitable for imaging subtle mechanical changes in early stages of diseases. [ 21 – 23 ] There is evidence suggesting that OCE has the capability to identify tissue microarchitecture in benign and malignant human breast tissues.…”

Section: Introductionmentioning

confidence: 99%

Viscoelasticity quantification of cancerous tongue using intraoral optical coherence elastography: a preliminary study

Zhang,

Han,

Luo

et al. 2024

Biomed. Opt. Express

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Quantifying the biomechanical properties of the tongue is significant for early diagnosis of tongue carcinoma. Therefore, an intraoral optical coherence elastography system based on a miniature probe was proposed here to evaluate the viscoelasticity of in vivo tongue for the first time. Results of experiments with Sprague-Dawley rats indicate that considerable elasticity diversity occurred between cancerous and normal tongues, and the corresponding ratio of their Young’s modulus was evaluated to be 3.74. It is also found that, viscosity in diseased tissue is smaller than that in normal tissue. Additionally, healthy, transitional and cancerous regions in the cancerous tongue can be distinguished easily by calculating viscoelasticity characteristics. Based on this preliminary attempt, our method with advantages of noninvasive, high-resolution, high-sensitivity and real-time detection and convenient operation may have good potential to become a useful tool for tongue carcinoma assessment after further optimization.

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Section: Introductionmentioning

confidence: 99%

Viscoelasticity quantification of cancerous tongue using intraoral optical coherence elastography: a preliminary study

Zhang,

Han,

Luo

et al. 2024

Biomed. Opt. Express

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Stiffness as measured with strain elastography is a prognostic factor for pT1/T2 tongue squamous cell carcinoma with muscle-layer invasion

Shibata

Ishikawa

Ishii

et al. 2023

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Minimally invasive correction of stress urinary incontinence in women with pelvic floor dysfunction

Rusina,

Zhevlakova,

Shelayeva

et al. 2024

Journal of obstetrics and women's diseases

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BACKGROUND: Pelvic floor dysfunction is widespread among young women. Stress urinary incontinence is a common manifestation of the dysfunction and, even in mild forms, affects the quality of life of patients. Much attention is focused on finding and improving minimally invasive methods for treating stress urinary incontinence in women of reproductive and perimenopausal age to prevent disease progression and improve quality of life. AIM: The aim of this study was to evaluate the immediate and long-term results of paraurethral injections of a high-density hyaluronic biopolymer for the correction of stress urinary incontinence in women of reproductive and perimenopausal age. MATERIALS AND METHODS: We examined 37 patients aged 44.6 ± 4.7 years with mild to moderate stress urinary incontinence combined with grade I to II genital prolapse. After general clinical and special studies (urination diaries, King’s and Pelvic Organ Prolapse / Urinary Incontinence Sexual Questionnaire, cough test, complex urodynamic study, ultrasound examination of the urethrovesical junction and pelvic floor ultrasound with compression elastography), paraurethral injection of 4.0 ml of the high-density hyaluronic biopolymer crosslinked with 1,4-butanediol diglycidyl ether was performed. The effectiveness of therapy was evaluated 1, 6 and 12 months after the procedure. RESULTS: A negative cough test was detected after one, six and 12 months of follow-up in 96.9, 73.1 and 43.8 % of women, respectively; the absence of stress urinary incontinence episodes according to urination diaries was in 85.7, 61.3 and 35.0 % of patients, respectively. Gradual resorption of the drug was monitored over 12 months of observation. An ultrasound examination showed a decrease in urethral mobility one month after the procedure. According to the results of elastography before treatment, the average value of the strain ratio of paraurethral tissues was 0.50 (0.30–0.69) (p 0.001), after one and six months — 0.88 (0.76–1.03) and 0.79 (0.66–1.07) (p 0.001 and p = 0.005 respectively). Thus, the stiffness of the paraurethral tissues of the proximal posterior wall of the urethra increased within six months after the procedure. When observing women after 12 months, the stiffness values of the studied tissues decreased and approached the values before treatment. During the entire observation period, the patients noted a decrease in the degree of discomfort due to problems with urination according to the questionnaires. CONCLUSIONS: The introduction of the high-density hyaluronic biopolymer helps to increase the stiffness of paraurethral tissues and improve the structural support of the urethra in patients with stress urinary incontinence. After the procedure, a 12-month follow-up revealed a decrease or absence of stress urinary incontinence episodes according to urination diaries and the preservation of the positive effect of treatment according to the results of the cough test. A gradual decrease in the effect of therapy is associated with biodegradation of the drug. This method of treating mild forms of stress urinary incontinence is effective for women of reproductive and perimenopausal age who do not plan surgical treatment, are interested in achieving a quick result of therapy and are informed that the effect decreases over time after the procedure.

show abstract

Stiffness of tongue squamous cell carcinoma measured using strain elastography correlates with the amount of collagen fibers in the tumor

Cited by 4 publications

References 37 publications

Viscoelasticity quantification of cancerous tongue using intraoral optical coherence elastography: a preliminary study

Viscoelasticity quantification of cancerous tongue using intraoral optical coherence elastography: a preliminary study

Stiffness as measured with strain elastography is a prognostic factor for pT1/T2 tongue squamous cell carcinoma with muscle-layer invasion

Minimally invasive correction of stress urinary incontinence in women with pelvic floor dysfunction

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