Stiffness and strength tailoring of cobalt chromium graded cellular structures for stress-shielding reduction

Limmahakhun, Sakkadech; Oloyede, Adekunle; Sitthiseripratip, Kriskrai; Xiao, Yin; Chen, Yan

doi:10.1016/j.matdes.2016.11.090

Cited by 181 publications

(107 citation statements)

References 33 publications

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“…In recent years, additively manufactured gradient structures for tissue engineering have been studied [37][38][39]41,44,64,65]; however these studies either focused on the mechanical properties or biological response independently. In this work, the biological and mechanical responses were assessed simultaneously allowing us to study the overall impact of the designed geometry of the scaffolds.…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have investigated the mechanical or biological response of metallic-based gradient porous designs produced by additive manufacturing [37][38][39][40][41][42][43][44][45]. The majority of these studies focused on gradient structures generated by abrupt changes between layers based on change in strut diameter or unit cell volume.…”

Section: Introductionmentioning

confidence: 99%

“…This design approach resulted in free nodes of outer layers that are not connected to inner layers, which caused a negative effect on the mechanical properties. Another approach frequently used to generate gradient structures is based on a sharp change in strut diameter between layers [41,42]. This design principle also results in a mismatch between layers negatively effecting the mechanical properties as well as tissue ingrowth and mineralization [42].…”

Section: Introductionmentioning

confidence: 99%

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Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds

Onal

Frith

Jurg

et al. 2018

Metals

122

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Abstract:Functionally graded lattice structures produced by additive manufacturing are promising for bone tissue engineering. Spatial variations in their porosity are reported to vary the stiffness and make it comparable to cortical or trabecular bone. However, the interplay between the mechanical properties and biological response of functionally graded lattices is less clear. Here we show that by designing continuous gradient structures and studying their mechanical and biological properties simultaneously, orthopedic implant design can be improved and guidelines can be established. Our continuous gradient structures were generated by gradually changing the strut diameter of a body centered cubic (BCC) unit cell. This approach enables a smooth transition between unit cell layers and minimizes the effect of stress discontinuity within the scaffold. Scaffolds were fabricated using selective laser melting (SLM) and underwent mechanical and in vitro biological testing. Our results indicate that optimal gradient structures should possess small pores in their core (~900 µm) to increase their mechanical strength whilst large pores (~1100 µm) should be utilized in their outer surface to enhance cell penetration and proliferation. We suggest this approach could be widely used in the design of orthopedic implants to maximize both the mechanical and biological properties of the implant.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds

Onal

Frith

Jurg

et al. 2018

Metals

122

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“…Stress shielding occurs when there is bone loss to the decrease in mechanical stress on the bone [10]. This can lead to the loosening between the implant and bone due to bone degeneration [11]. Stress shielding can occur when there is a difference between the Young's modulus of the implant and bone, leading to an inhomogeneous stress transfer [12].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Insight into cytotoxicity of Mg nanocomposites using MTT assay technique

Ong

Meenashisundaram

et al. 2017

Materials Science and Engineering: C

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“…Traditionally manufactured lattice constructions using casting and forging techniques cannot achieve the levels of additive manufacturing. However, problems appear because of melting: A manifestation of brittle properties and geometry deviations [4][5][6][7]. Different materials and melting modes are investigated to improve the quality of constructions [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Design and Optimization Lattice Endoprosthesis for Long Bones: Manufacturing and Clinical Experiment

Bolshakov

Raginov

Egorov³

et al. 2020

Materials

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The article is devoted to the construction of lattice endoprosthesis for a long bone. Clinically, the main idea is to design a construction with the ability to improve bone growth. The article presents the algorithm for such a design. The construction should be produced by additive manufacturing. Such an approach allows using not only metallic materials but also ceramics and polymers. The algorithm is based on the influence function as a method to describe the elementary cell geometry. The elementary cell can be described by a number of parameters. The influence function maps the parameters to local stress in construction. Changing the parameters influences the stress distribution in the endoprosthesis. In the paper, a bipyramid was used as an elementary cell. Numerical studies were performed using the finite element method. As a result, manufacturing construction is described. Some problems for different orientations of growth are given. The clinical test was done and histological results were presented.

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Stiffness and strength tailoring of cobalt chromium graded cellular structures for stress-shielding reduction

Cited by 181 publications

References 33 publications

Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds

Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds

Insight into cytotoxicity of Mg nanocomposites using MTT assay technique

Design and Optimization Lattice Endoprosthesis for Long Bones: Manufacturing and Clinical Experiment

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