Sticholysin II shows similar immunostimulatory properties to LLO stimulating dendritic cells and MHC-I restricted T cell responses of heterologous antigen

Marine natural products

“…Sticholysin II, and likely also its isoform sticholysin I, induce maturation of dendritic cells through a toll-like receptor 4/myeloid differentiation primary response gene 88-dependent pathway, 597 and that sticholysin II shares similar abilities to act as an immunostimulant to those of the evolutionarily distinct pore-forming peptide listeriolysin O (bacteria Listeria monocytogenes ). 598 Kunitz-type peptides from the sea anemone Heteractis crispa protect neuronal cells from the toxic effects of 6-hydroxydopamine. 599 The search for new insulin-like peptides has identified the tentacles of the sea anemone Oulactis sp.…”