Stężenie TSH wiąże się z podwyższonym ryzykiem raka tarczycy u pacjentów z guzkami tarczycy

Fighera, Tayane Muniz; Perez, Camila Luhm Silva; Faris, Nadia; Scarabotto, Patrícia Cristina; Silva, Thamires Tixiliski da; Cavalcanti, Teresa Cristina Santos; Mesa, Cléo Otaviano; Miasaki, Fabíola Yukiko; Filho, Gilberto Da Paz; Carvalho, Gisah Amaral de

doi:10.5603/ep.a2015.0059

Cited by 10 publications

(5 citation statements)

References 33 publications

(38 reference statements)

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“…Tumors were developed from the injected PCCL3‐Neo cells. That tumors were developed from the injected PCCL3 cells in mice with elevated TSH are consistent with accumulated evidence to indicate that high TSH concentrations are closely associated with an increased risk of thyroid cancer . Thus, PCCL3 cells xenograft tumors could serve as a model to reflect the effects of TSH on follicular cell tumorigenesis.…”

Section: Discussionsupporting

confidence: 78%

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Loss of tyrosine phosphorylation at Y406 abrogates the tumor suppressor functions of the thyroid hormone receptor β

Park

Zhao

Cheng

2016

Molecular Carcinogenesis

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We have recently identified that phosphorylation at tyrosine (Y)406 is critical for the tumor suppressor functions of the thyroid hormone receptor β1 (TRβ) in a breast cancer line. However, still unclear is whether the critical tumor suppressor role of phosphorylated Y406 of TRβ is limited to only breast cancer cells or could be extended to other cell types. In the present studies, we addressed this question by stably expressing TRβ, a mutated TRβ oncogene (PV), or a TRβ mutated at Y406 (TRβY406F) in rat PCCL3 thyroid follicular cells and evaluated their tumor characteristics in athymic mice with elevated thyroid stimulating hormone. PCCL3 cells stably expressing PV (PCCL3-PV), TRβY406F (PCCL3-TRβY406F), or vector only (PCCL3-Neo) developed tumors with sizes in the rank order of TRβY406F>PV = Neo, whereas PCCL3 cells expressing TRβ (PCCL3-TRβ) barely developed tumors. As evidenced by markedly elevated Ki67, cyclin D1, and p-Rb protein abundance, proliferative activity was high in PV and TRβY406F tumors, but low in TRβ tumors. These results indicate that TRβ acted as a tumor suppressor in PCCL3 cells, whereas TRβY406F and PV had lost tumor suppressor activity. Interestingly, TRβY406F tumors had very low necrotic areas with decreased TNFα-NFκB signaling to lower apoptotic activity. In contrast, PV tumors had prominent large necrotic areas, with no apparent changes in TNFα-NFκB signaling, indicating distinct oncogenic activities of mutant PV and TRβY406F. Thus, the present studies uncovered a novel mechanism by which TRβ could function as a tumor suppressor through modulation of the TNFα-NFκB signaling. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 78%

“…The role of TSH in thyroid carcinogenesis has been debated for years. Some studies have implied that TSH could act to initiate thyroid carcinogenesis , and suggested that high TSH concentrations are closely associated with an increased risk of thyroid cancer . However, other reports have disputed this possibility .…”

Section: Discussionmentioning

confidence: 99%

Loss of tyrosine phosphorylation at Y406 abrogates the tumor suppressor functions of the thyroid hormone receptor β

Park

Zhao

Cheng

2016

Molecular Carcinogenesis

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“…The carcinoma risk in patients with thyroid nodules increased with increasing serum thyroid-stimulating hormone concentration, with a significant elevation in patients with serum thyroid-stimulating hormone levels above 1.64 mU/L ( P < 0.001). [25] Furthermore, Betry et al [26] confirmed an increase of thyroid-stimulating hormone in conjunction with BMI in obese subjects and this increase was correlated with leptin independently of BMI.…”

Section: Discussionmentioning

confidence: 98%

Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer

Wang²,

Chen³

et al. 2017

Medicine

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Epidemiological studies suggest that obesity is a risk of thyroid cancer, especially papillary thyroid cancer (PTC). However, the associations of obesity and clinic–pathological features, especially the association of body mass index (BMI) and lymph node metastasis of thyroid cancer are unclear. Seven hundred ninety-six primary patients with PTC were enrolled in this retrospective cohort study. The relationships between BMI and clinic-pathological features of PTC were evaluated by logistic regression models based on the 5-point increase in BMI and BMI quartiles (underweight, normal weight, overweight, and obesity). The 5-point increase in BMI was strongly associated with extra-thyroidal invasion [odds ratio (OR) 2.201, P < 0.001], primary tumor size larger than 1 cm (OR 1.267, P = 0.027), advanced tumor node metastasis (TNM) staging (OR 1.479, P = 0.004), and multifocality (OR 1.31, P = 0.01) in multivariable-adjusted models. The relationships between BMI and lymph node metastasis of PTC were evaluated by Mann–Whitney U test. The mean number of positive central lymph nodes and lateral nodes were increased with the increase of BMI when BMI ≥18.5 kg/m2. It was not shown in underweight group. The present study found that increased BMI was associated with the lymph node metastases (LNMs) of patients with PTC, and other invasive features, including large tumor size, extra-thyroidal invasion, advanced TNM staging, and multifocality. Further studies with long-term follow-up are needed to confirm this finding.

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“…In humans there was a statistically significant increase of the TSH level following mobile phone use [ 63 ]. Elevated levels of TSH in humans is associated with thyroid growth and has been postulated to increase the risk for thyroid cancer [ 67 , 68 ]. Certainly thyroid function deserves to be further studied in person using wireless phones.…”

Section: Discussionmentioning

confidence: 99%

Increasing incidence of thyroid cancer in the Nordic countries with main focus on Swedish data

Carlberg

Hedendahl

Ahonen³

et al. 2016

BMC Cancer

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BackgroundRadiofrequency radiation in the frequency range 30 kHz–300 GHz was evaluated to be Group 2B, i.e. ‘possibly’ carcinogenic to humans, by the International Agency for Research on Cancer (IARC) at WHO in May 2011. Among the evaluated devices were mobile and cordless phones, since they emit radiofrequency electromagnetic fields (RF-EMF). In addition to the brain, another organ, the thyroid gland, also receives high exposure. The incidence of thyroid cancer is increasing in many countries, especially the papillary type that is the most radiosensitive type.MethodsWe used the Swedish Cancer Register to study the incidence of thyroid cancer during 1970–2013 using joinpoint regression analysis.ResultsIn women, the incidence increased statistically significantly during the whole study period; average annual percentage change (AAPC) +1.19 % (95 % confidence interval (CI) +0.56, +1.83 %). Two joinpoints were detected, 1979 and 2001, with a high increase of the incidence during the last period 2001–2013 with an annual percentage change (APC) of +5.34 % (95 % CI +3.93, +6.77 %). AAPC for all men during 1970–2013 was +0.77 % (95 % CI −0.03, +1.58 %). One joinpoint was detected in 2005 with a statistically significant increase in incidence during 2005–2013; APC +7.56 % (95 % CI +3.34, +11.96 %). Based on NORDCAN data, there was a statistically significant increase in the incidence of thyroid cancer in the Nordic countries during the same time period. In both women and men a joinpoint was detected in 2006. The incidence increased during 2006–2013 in women; APC +6.16 % (95 % CI +3.94, +8.42 %) and in men; APC +6.84 % (95 % CI +3.69, +10.08 %), thus showing similar results as the Swedish Cancer Register. Analyses based on data from the Cancer Register showed that the increasing trend in Sweden was mainly caused by thyroid cancer of the papillary type.ConclusionsWe postulate that the whole increase cannot be attributed to better diagnostic procedures. Increasing exposure to ionizing radiation, e.g. medical computed tomography (CT) scans, and to RF-EMF (non-ionizing radiation) should be further studied. The design of our study does not permit conclusions regarding causality.

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Stężenie TSH wiąże się z podwyższonym ryzykiem raka tarczycy u pacjentów z guzkami tarczycy

Abstract: Our results suggest that in patients with nodular thyroid disease the carcinoma risk rose in parallel with serum TSH concentration, with significant increases evident in patients with serum TSH greater than 1.64 mU/L.

Cited by 10 publications

References 33 publications

Loss of tyrosine phosphorylation at Y406 abrogates the tumor suppressor functions of the thyroid hormone receptor β

Loss of tyrosine phosphorylation at Y406 abrogates the tumor suppressor functions of the thyroid hormone receptor β

Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer

Increasing incidence of thyroid cancer in the Nordic countries with main focus on Swedish data

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