Stewartiacids A–N, C-23 carboxylated triterpenoids from Chinese Stewartia and their inhibitory effects against ATP-citrate lyase and NF-κB

Abstract

Fourteen new C-23 carboxylated triterpenoids (stewartiacids A–N, 1–14) were obtained from the ‘vulnerable’ plant Stewartia sinensis. 11 and 12 showed inhibitory effects against ACL.

Forrestiacids E–K: Further [4 + 2]-Type Triterpene–Diterpene Hybrids as Potential ACL Inhibitors from the Vulnerable Conifer Pseudotsuga forrestii

“…And thus, ACL has emerged as a promising drug target in cardiovascular medicine, as well as cancer. , Traditionally, natural products have inherent advantages for drug discovery . In the course of finding new ACL inhibitors from plant sources, a great deal of effort has been paid by our lab in recent years. ,,, In this study, all the isolates (except for 5 , due to decomposition of the sample) were evaluated for their ACL inhibitory effects. The known inhibitor BMS 303141 was used as the positive control (IC 50 : 0.46 ± 0.13 μM). ,,, …”

Highly Oxygenated Triterpenoids and Diterpenoids from Fructus Rubi (Rubus chingii Hu) and Their NF-kappa B Inhibitory Effects

“…It has been regarded as a potential target for the regulation of dysfunction of immunity and inflammation. Recently, a few triterpenoids and diterpenoids from Stewartia sinensis [ 11 ] and Pseudotsuga sinensis [ 12 ] were found to have significant NF- κ B inhibitory effects. In the present study, all the isolated terpenoids ( 1 – 25 ) were evaluated for their NF- κ B inhibitory activities.…”

“…HEK293 with a stable NF- κ B expression cell line was used for the luciferase assay [ 11 , 12 , 47 ]. Cells were maintained at 37 °C and 5% CO 2 atmosphere in Dulbecco’s modified Eagle’s medium with 100 U/mL benzylpenicillin 100 μg/mL streptomycin, 2 mM glutamine, and 10% fetal bovine serum.…”

“…Modern pharmacological studies have revealed that the chemical components from Fructus Rubi exhibit a broad spectrum of bioactivities, such as being anti-aging [ 6 ], anti-cancer [ 7 ], anti-oxidant [ 7 , 8 ], and anti-diabetic [ 9 ]. With the aim of obtaining more structurally interesting and bioactive naturally occurring triterpenoids and diterpenoids [ 10 , 11 , 12 ], a phytochemical investigation of a commercially available sample of Fructus Rubi was carried out, which resulted in the isolation of three new highly oxygenated pentacyclic triterpenoids ( 1 – 3 ) and one new ent -kaurane-type diterpenoid ( 21 ), along with 21 related known terpenoid compounds ( 4 – 20 and 22 – 25 ) ( Figure 1 ). Herein, the isolation, structural elucidation, and NF- κ B inhibitory activities of these compounds are reported.…”

Amentotaxins C–V, Structurally Diverse Diterpenoids from the Leaves and Twigs of the Vulnerable Conifer Amentotaxus argotaenia and Their Cytotoxic Effects

“…Appropriate amounts of the endangered/vulnerable plant samples are suitable for phytochemical studies, especially the renewable twigs and leaves/needles . The identification of new molecules from REPs reveals the importance of conservation efforts to prevent species diversity loss in the control of human diseases. , Since 2013, a special program has been launched to systematically identify bioactive/novel natural products from REPs endemic to China. ,, Of these, the endangered conifers (formally the Division Coniferophyta) have aroused our special interest. , Globally, ca. 34% of the conifer species on the IUCN Red List are currently threatened with extinction .…”