Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats

Jeppesen, Per Bendix; Gregersen, Søren; Alstrup, Kirsten; Hermansen, Kjeld

doi:10.1078/0944-7113-00081

Cited by 242 publications

(152 citation statements)

References 15 publications

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“…Effect of stevioside in isolated mouse islets and the clonal beta cell line INS-1 was investigated and found that glycoside stevioside exerts antihyperglycaemic, insulinotropic, and glucagonostatic actions in the type 2 diabetic GK rat [41] . In another study it was concluded that stevioside and steviol stimulate insulin secretion via a direct action on beta cells [42] .…”

Section: Stevia Rebaudiana (Asteraceae)mentioning

confidence: 99%

An overview on antidiabetic medicinal plants having insulin mimetic property

Patel

Prasad

Kumar

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

612

379

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Section: Stevia Rebaudiana (Asteraceae)mentioning

confidence: 99%

An overview on antidiabetic medicinal plants having insulin mimetic property

Patel

Prasad

Kumar

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

612

379

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“…Stevioside and its aglucone steviol directly potentiate the glucose-stimulated insulin secretion, insulin utilization decreased protein levels of phosphoenol pyruvate carboxykinase by slowing down gluconeogenesis [243]. Stevioside also possess blood pressure lowering properties [244] which can be used as an effective means of preventing diabetic macrovascular complications [242]. Therefore, a multifactorial approach combining blood glucose, blood pressure and lipid lowering would be most effective in treating diabetes and preventing diabetic complications [245].…”

Section: Plants Possessing Hypoglycemic Activitymentioning

confidence: 99%

A Review of Recent Investigations on Medicinal Herbs Possessing Anti-Diabetic Properties

Aggarwal¹,

Shishu²

2011

J Nutrition Disorder Ther

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Globally, the pervasiveness of chronic, non-communicable disease diabetes mellitus is growing by leaps and bounds. It is one of the major causes of premature morbidity and mortality worldwide. Almost 3.2 million people die of diabetes across the world every year. The worldwide prevalence of diabetes is 6.4% (corresponding to 285 million people); this varies from 10.2% in the Western Pacific to 3.8% in the African region and expected to grow up to 7.4% (439 million) of the adult population by 2030. In the last 20 years there has been a threefold increase in the prevalence of diabetes. It is estimated that there are 30 to 33 million diabetics in India now, and every fourth diabetic in the world today is an Indian. Indians are genetically more susceptible to diabetes and the WHO predicts the number of diabetics in India would go up to 80 million by 2030. WHO has also issued a warning that India is going to be the diabetes capital of the world with Chennai emerging as the diabetic capital of India. Many plants possessing hypoglycemic principles/ properties are known to exist in nature. Also a large number of polyherbal formulations (PHF's) derived from these plants are presently being prescribed as medicinal/dietary supplements for diabetes mellitus. Even the WHO (World Health Organization) approves the use of plant drugs for different diseases, including diabetes mellitus. However, these formulations lack proper standardization of the active constituents. There is an urgent need to address to the issues of scientific authenticity about their efficacy, safety and their interaction with modern allopathic drugs. The paper reviews composition, active principles and pharmacological effects of some important plants which are widely used in commercially available herbal and polyherbal formulations and provides a detailed list of plants reported to possess potential anti-diabetic activity.

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“…Aliment., 14(1), 5-13. DOI: 10.17306/J.AFS.2015.1.1 www.food.actapol.net of Paraguay sweet leaves exhibit cholagogic (Kochikyan et al, 2006), anti-infl ammatory (Jayaraman et al, 2008;Sehar et al, 2008) diuretic activity, prevent gastrointestinal ulcers (Kochikyan et al, 2006), exhibit antihypertensive (Chan et al, 2000;Lee et al, 2001;Jeppesen et al, 2002), antihiperglycemic (Suanarunsawat and Chaiyabutr, 1997;Jeppesen et al, 2000Jeppesen et al, , 2002Chen et al, 2006), antirotaviral activity (Suanarunsawat and Chaiyabutr, 1997;Takahashi et al, 2001), exhibit a benefi cial effect on glucose (Shivanna et al, 2013;Suanarunsawat and Chaiyabutr, 1997;Toskulkao et al, 1995) and kidney (Jutabha et al, 2000) metabolisms.…”

Section: Stevia Leaves In the Prevention Of Civilization Diseasesmentioning

confidence: 99%

Untitled

2015

Acta Sci Pol Technol Aliment

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Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats

Cited by 242 publications

References 15 publications

An overview on antidiabetic medicinal plants having insulin mimetic property

An overview on antidiabetic medicinal plants having insulin mimetic property

A Review of Recent Investigations on Medicinal Herbs Possessing Anti-Diabetic Properties

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