Stevioside and Related Compounds – Molecules of Pharmaceutical Promise: A Critical Overview

Brahmachari, Goutam; Mandal, L. N.; Roy, Rustum; Mondal, Sudip; Brahmachari, A. K.

doi:10.1002/ardp.201000181

Cited by 118 publications

(64 citation statements)

References 98 publications

(146 reference statements)

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“…Posterior research performed by Geuns, et al [46] have shown that steviol or related metabolites do not accumulate in the human body, and that at least in healthy human subjects pure stevioside taken at a dose of 750 mg/day had no effect on either blood pressure of insulin levels. Following those reviews, clinical evidence emerged that suggested stevioside can be used by diabetics and hypertensive patients and they may also offer therapeutic benefits, as they have anti-hyperglycemic, anti-hypertensive, anti-inflammatory, anti-tumor, antidiarrheal, diuretic, and immuno-modulatory actions [38,[47][48][49][50][51][52][53][54]. Stevia extracts, besides having therapeutic properties, contain a high level of sweetening compounds, known as steviol glycosides, which are thought to possess antioxidant, antimicrobial and antifungal activity.…”

Section: Studies On Safe Consumption Of the Stevia And Its Use By Conmentioning

confidence: 99%

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2016

Journal of Nutrients

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Section: Studies On Safe Consumption Of the Stevia And Its Use By Conmentioning

confidence: 99%

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2016

Journal of Nutrients

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“…, v i is the number of ions formed when the solute dissociates, R is the universal gas constant (83.133 dm 3 ·bar·kmol…”

Section: Determination Of Stevioside Rejectionmentioning

confidence: 99%

“…Recently, there is an increasing demand for low calorie natural sweeteners as a substitute for sucrose and other synthetic sweeteners such as saccharine and aspartame. Stevia a perennial plant species commonly called as "sweet herb" is gaining significant importance as a natural sweetner in different parts of the world and is expected to develop into a major source of high potency sweetener for the growing natural food market [2][3][4]. Steviol glycosides are natural diterpene glycosides extracted from the leaves of Stevia rebaudiana Bertoni.…”

Section: Introductionmentioning

confidence: 99%

Simple extraction and membrane purification process in isolation of steviosides with improved organoleptic activity

Rao¹,

Prasad²,

Sridhar³

et al. 2012

ABB

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In recent years there has been increasing demand for natural non-nutritive high intensity sweeteners with low-calorie value as an alternative to sucrose. Extracts of the leaves of Stevia rebaudiana (Bertoni), have been known for their sweet taste. Steviosides and rebaudioside-A are the two major diterpenoid glucosides components present in the leaf extracts of the stevia, these glycosides are 300 times sweeter than sugar and also exhibits wide therapeutic activity. The conventional methods of isolation of steviosides involve long extraction and purification procedures; therefore optimization of product yields is a challenging problem. The present study, establishes a new improvised process of extraction of steviosides from the stevia leaves in which the dry treated leaves were grounded, defatted, and extracted through pressurized hot water extractor (PHWE), followed by purification and concentration of the sweet glycosides through ultra (UF) and nano (NF) membrane filtration in obtaining high (98.2%) purity steviosides. This process established "green" method for isolation of high quality steviol glycosides, with improved final yield is 10.1% from 11% of crude leaf extract and observed the improved organoleptic and biological activity (antioxidant). Thus the method confirms a simple, in-expensive and eco-friendly process in obtaining pure steviosides.

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“…Stevia leaves are thought to possess useful pharmaceutical properties (Brahmachari et al, 2011) and several studies have reported a number of health benefits associated with stevia consumption. It has been found that the leaves of S. Rebaudiana have medicinal properties; antimicrobial, antiviral, antifungal, antihypertensive, anti-hyperglycaemic, anti-inflammatory, anti-tumour and diuretic effects (Wheeler et al, 2008;Roberts and Munro, 2009;Gheisar and Kim, 2014;Onakpoya and Heneghan, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of Stevia Consumption on Blood Pressure, Stress Hormone Levels and Anthropometrical Parameters in Healthy Persons

Al-Dujaili¹,

Twaij²,

Bataineh³

et al. 2017

American Journal of Pharmacology and Toxicology

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Stevia is a natural sweetener containing steviol glycosides known to be several times sweeter than sucrose. It is thought to have several beneficial properties though some evidence state it may have detrimental effects. The aim of this study was to investigate the potential beneficial or harmful effects of stevia consumption by exploring its effects on blood pressure, stress hormone levels and anthropometrical markers in A crossover placebo controlled study was conducted on 16 volunteers randomly assigned to consume either stevia or a placebo (sugar) for one week. The measurements were attained on three different occasions and each volunteer was allowed a 3-day initiation period before baseline and in between interventions. The systolic BP increased following stevia intake from 114.5±12.7 to 119.9±12.9mmHg (p<0.001) and diastolic BP from 70.8±9.4 to 75.7±9.6mmHg (p<0.01). Systolic BP increased slightly after the sugar placebo to 115.3±13.6 mmHg (not significant). The mean free cortisol excreted in urine has increased from 91.8±49.1 to 125.7±60.5nmole/day (p<0.01) after the stevia and to 109.1±42.6nmole/day after the placebo (p = 0.210). The ratio of urinary free cortisol/cortisone showed a statistically significant increase from 1.73±0.78 to 2.65±1.03 after stevia (p<0.0001). Salivary cortisol levels have also increased (p<0.01 at AM) after stevia. Placebo intake did not produce a significant change in salivary cortisol. The ratio of salivary cortisol/cortisone during the stevia has increased only in the morning (from 1.22±0.65 to 1.75±0.72, p = 0.05) and a modest increase in the daily average of salivary cortisol/cortisone. There was small insignificant reduction in weight and BMI after stevia intervention (p = 0.246 and p = 0.249 respectively). In conclusion, we have shown that short term stevia intake produced a small but significant increase in BP and effect on body weight and BMI were not significant. The rise in BP might be due to the increase in cortisol levels and cortisol/cortisone ratio indicating that stevia may possibly inhibit 11β-HSD2 enzyme by reducing the conversion of cortisol into cortisone. Therefore caution should be taken by the public who want to consume stevia for longer period of time as a weight reducing sweetener.

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Stevioside and Related Compounds – Molecules of Pharmaceutical Promise: A Critical Overview

Cited by 118 publications

References 98 publications

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Simple extraction and membrane purification process in isolation of steviosides with improved organoleptic activity

Effect of Stevia Consumption on Blood Pressure, Stress Hormone Levels and Anthropometrical Parameters in Healthy Persons

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