Stevioside acts directly on pancreatic β cells to secrete insulin: Actions independent of cyclic adenosine monophosphate and adenosine triphosphate—sensitivie K+-channel activity

Jeppesen, Per Bendix; Gregersen, Søren; Poulsen, Claus; Hermansen, Kjeld

doi:10.1016/s0026-0495(00)91325-8

Cited by 248 publications

(199 citation statements)

References 20 publications

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“…In this regard, Kudelski et al showed that intraperitoneal injection of NA in rats leads to an increase in nicotinamide adenine According to previous studies, stevia derivatives such as stevioside reduce the blood glucose level. In a similar study in 2000, Jeppesen et al showed that stevia derivatives by affecting pancreatic β-cells increase the insulin level and reduce blood glucose (31). As revealed by other researchers, the anti-diabetic effect of stevia and its glycoside might be exerted through the stimulation of peripheral glucose utilization or enhancement of glycolytic and glycogenic processes, concomitant with the decline in glycogenolysis and gluconeogenesis and glucose absorption in the duodenum (31)(32)(33)(34)(35)(36)(37)(38)(39).…”

Section: Discussionmentioning

confidence: 95%

Effect of the Aquatic Extract of Stevia on the Serum Level of Interleukin-6 in Streptozotocin-Nicotinamide Induced Diabetic Rats

et al. 2017

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Background: Diabetes, as a common chronic disorder, is the seventh leading cause of death in the world. This disorder is classified into two major types: type I and type II diabetes mellitus. Recently, researchers have identified a higher level of inflammatory cytokines in patients with type II diabetes, compared to the normal population. Today, plant-based therapies, given their anti-diabetic properties, have attracted the researchers' attention. One of the medicinal plants with anti-diabetic effects is Stevia rebaudiana Bertoni. Various hypotheses have been proposed to explain how stevioside, as a derivative of Stevia rebaudiana, can cause such a significant decline in blood glucose level. To the best of our knowledge, the exact anti-inflammatory and immunomodulatory effects of the aquatic extract of stevia are not fully understood. Therefore, the current research aimed to evaluate whether stevia can improve the interleukin-6 (IL-6) level in streptozotocin-nicotinamide-induced diabetic rats. Methods:In the present study, a cohort of rats was divided into five groups, each containing 11 rats: (1) normoglycemic group, receiving 1 mL of water; (2) diabetic control group, receiving 1 mL of water; (3) and (4) diabetic groups treated with the aquatic extracts of stevia (400 mg/kg) and metformin (500 mg/kg), respectively; and (5) healthy group treated with the aquatic extract of stevia (400 mg/kg). At the end of the experiment, the rats were sacrificed and blood samples were collected from the heart for evaluating serum IL-6 changes. Statistical analysis was performed, using one-way analysis of variance (ANOVA), followed by the least significant difference (LSD) post-hoc multiple comparison test. Results:The present results showed that IL-6 (P = 0.001) and fasting blood sugar (FBS) (P < 0.001) levels significantly increased in all diabetic groups, compared to healthy rats. Surprisingly, treatment with stevia could significantly reduce FBS (P < 0.001), as well as IL-6 level (P = 0.001) in comparison with the diabetic group.Conclusions: Based on the findings, inflammation can be ameliorated with the whole aquatic extract of stevia, as an anti-diabetic compound. Therefore, by considering IL-6 level as an indicator of insulin resistance, stevia can lead to a decline in IL-6 level and thereby reduce insulin resistance in diabetic patients.

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Section: Discussionmentioning

confidence: 95%

Effect of the Aquatic Extract of Stevia on the Serum Level of Interleukin-6 in Streptozotocin-Nicotinamide Induced Diabetic Rats

et al. 2017

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“…In another study it was concluded that stevioside and steviol stimulate insulin secretion via a direct action on beta cells [42] . The natural sweetener stevioside, which is found in the plant Stevia rebaudiana acts through stimulating insulin secretion via direct action on the 毬-cells of pancreatic islets [8] .…”

Section: Stevia Rebaudiana (Asteraceae)mentioning

confidence: 99%

An overview on antidiabetic medicinal plants having insulin mimetic property

Patel

Prasad

Kumar

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

612

379

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“…7,8 Stevioside was found to exert antihyperglycemic and insulinotropic effects in a non-obese animal model of type 2 diabetes 9 by acting directly on pancreatic cells. 10 However, its effects on adipose tissue and obesity-associated insulin resistance, inflammation, oxidative stress and atherosclerosis have not been determined. Therefore, our aim was to measure these effects and identify underlying molecular pathways.…”

Section: Introductionmentioning

confidence: 99%

Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice

et al. 2009

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Objective: Stevioside is a non-caloric natural sweetener that does not induce a glycemic response, making it attractive as sweetener to diabetics and others on carbohydrate-controlled diets. Obesity is frequently associated with insulin resistance and increased inflammation and oxidative stress. Therefore, we investigated its effects on insulin resistance, inflammation and oxidative stress related to atherosclerosis in obese insulin-resistant mice.Research design: Twelve-week-old mice were treated with stevioside (10 mg kg À1 , n ¼ 14) or placebo (n ¼ 20) for 12 weeks. Results: Stevioside had no effect on weight and triglycerides, but lowered glucose and insulin. Stevioside treatment improved adipose tissue maturation, and increased glucose transport, insulin signaling and antioxidant defense in white visceral adipose tissues. Together, these increases were associated with a twofold increase of adiponectin. In addition, stevioside reduced plaque volume in the aortic arch by decreasing the macrophage, lipid and oxidized low-density lipoprotein (ox-LDL) content of the plaque. The higher smooth muscle cell-to-macrophage ratio was indicative for a more stable plaque phenotype. The decrease in ox-LDL in the plaque was likely due to an increase in the antioxidant defense in the vascular wall, as evidenced by increased Sod1, Sod2 and Sod3. Circulating adiponectin was associated with improved insulin signaling and antioxidant defense in both the adipose tissue and the aorta of stevioside-treated mice. Conclusion: Stevioside treatment was associated with improved insulin signaling and antioxidant defense in both the adipose tissue and the vascular wall, leading to inhibition of atherosclerotic plaque development and inducing plaque stabilization.

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Stevioside acts directly on pancreatic β cells to secrete insulin: Actions independent of cyclic adenosine monophosphate and adenosine triphosphate—sensitivie K+-channel activity

Cited by 248 publications

References 20 publications

Effect of the Aquatic Extract of Stevia on the Serum Level of Interleukin-6 in Streptozotocin-Nicotinamide Induced Diabetic Rats

Effect of the Aquatic Extract of Stevia on the Serum Level of Interleukin-6 in Streptozotocin-Nicotinamide Induced Diabetic Rats

An overview on antidiabetic medicinal plants having insulin mimetic property

Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice

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