Steviol Rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments
Shuang Hao,
Brian Guthrie,
Soo-Kyung Kim
et al.
Abstract:Sucrose provide sweetness and energy when it binds to both the Venus fly trap domains (VFD) of heterodimeric sweet taste receptor (T1R2/T1R3),1 while non-caloric sweeteners (Sucralose, Aspartame, Neotame, Saccharin, Acesulfame-K (Ace-K), Suosan, SC-45647, Fructose, and D-Tryptophan) bind only at the VFD of T1R2 (VFD2) to provide high-intensity sweetness.2 Here, we address the binding mechanism of various steviol glycosides (Rebaudioside B (RebB), RebM, RebD, Rubusoside (Rubu), RebC), artificial sweeteners (Neo… Show more
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