Stevens-Johnson Syndrome During Treatment With Cimetidine

Ahmed, Alhumidi; McLarty, D.G.; Sharma, Sunita; Masawe, A. E. J.

doi:10.1016/s0140-6736(78)91910-4

Cited by 17 publications

(2 citation statements)

References 4 publications

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“…But severe ranitidine‐related mucocutaneous events have only been reported in one patient with idiopathic thrombocytopenic purpura 6 . Cimetidine, another H 2 receptor antagonist, has been reported to be associated with Stevens–Johnson syndrome in two case reports 7,8 . Adverse cutaneous reactions to drugs always occur within 1–2 weeks of initiation of the drug, and subside after the discontinuation of medication 2,9 .…”

Section: Discussionmentioning

confidence: 99%

Ranitidine‐related Stevens–Johnson syndrome in patients with severe liver diseases: A report of two cases

Chen

Huang

et al. 2001

J of Gastro and Hepatol

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Ranitidine is widely used and well tolerated. Ranitidine-related skin eruption is rare and usually mild. We presented two patients who developed Stevens-Johnson syndrome after ranitidine therapy. Before therapy, both patients had severe liver disease and jaundice. The first was a case of ketoconazole-induced hepatitis, and the second was a case of hepatitis C-related liver cirrhosis with hepatocellular carcinoma. Ranitidine was the most likely drug responsible for causing Stevens-Johnson syndrome in these two patients.

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Section: Discussionmentioning

confidence: 99%

Ranitidine‐related Stevens–Johnson syndrome in patients with severe liver diseases: A report of two cases

Chen

Huang

et al. 2001

J of Gastro and Hepatol

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“…Comments: H 2-blockers have been on the market for the past 10 years, but skin rashes due to their use have been thought rare until recently. A few reports on eruptions such as urticaria (1), maculopapular (2), lichenoid eruptions (3) and erythema multiforme (4) caused by H 2-blockers are available, but only a few serious cases with Stevens-Johnson syndrome due to cimetidine (5) have appeared in the literature. To the author's knowledge, only lichenoid eruptions (3) as a side effect deriving from roxatidine have been reported.…”

Section: Erythema Multiforme Caused By the H 2 -Blocker Roxatidinementioning

confidence: 99%