Sterols. CXII. Sapogenins. XLI. The Preparation of Trillin and its Conversion to Progesterone

Marker, Russell E.; Krueger, John W.

doi:10.1021/ja01869a023

Cited by 48 publications

(32 citation statements)

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“…Diosgenin has been used in traditional Chinese medicine for treatment of urethral and renal infections [10]. Diosgenin, made by hydrolysis of saponins, which were extracted from Kallstroemia pubescens, a plant which grows in India, shows presumed ability to minimize post-menopausal symptoms [11]. In Turkey, diosgenin is used as a good antispasmodic, that it can be used for cramps, coughs and for muscular spasms [12].…”

Section: Epidemiologic Studiesmentioning

confidence: 99%

Phytochemistry, Anthelmintic study of herbaceous aerial part of Kallstroemia pubescens (G. Don) & Review of Novel Effects of Diosgenin: A Plant Derived Steroid

Nigam¹

2018

IJCRPP

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The genus is named after A. Kallstroem who lived in the 18th century. Diosgenin is an aglycone of the steroidal saponin, dioscin in yam and is a principal raw material for the industrial production of steroid drugs. It belongs to triterpene group and is of great interest to the pharmaceutical industry because of its estrogenic effect on the mammary gland. It plays an important role in cholesterol metabolism and it is responsible for morphological and biochemical changes in megakaryocyte cells. Diosgenin is an important steroidal metabolite used as a starting material for the synthesis of steroidal drugs, as it exhibits estrogenic activity. In this, we have focused on the potential effects of diosgenin and its pharmacological properties. Keywords: Kallstroem; Diosgenin; Steroids; Sapogenins; Pharmacology.

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Section: Epidemiologic Studiesmentioning

confidence: 99%

Phytochemistry, Anthelmintic study of herbaceous aerial part of Kallstroemia pubescens (G. Don) & Review of Novel Effects of Diosgenin: A Plant Derived Steroid

Nigam¹

2018

IJCRPP

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“…Marker and co-workers [3][4][5] first discovered that the spiroketal ring system could be opened through acetolysis of diosgenin with acetic anhydride under autoclave conditions, and since then many efforts have been paid to make such a transformation more effective. [6][7][8][9][10][11] Oxidation of the resultant pseudodiosgenin diacetate 2, followed by hydrolysis of the oxidized product diosone 5 in acetic acid afforded 16-DPA.…”

Section: Introductionmentioning

confidence: 99%

“…The key step in the synthesis involving oxidation of pseudodiosgenin diacetate 2 to diosone 5 was carried out generally with chromium trioxide (CrO 3 ) as oxidant. [3][4][5]7,11 Other oxidants such as potassium dichromate, pyridinium chlorochromate, pyridinium dichromate and mixtures of them 12,13 were also examined to effect the oxidation reaction. Recently Chowdhury et al 13 found that the amount of CrO 3 could be reduced by about 50% when the oxidation transformation from 2 to 5 was performed under sonication.…”

Section: Introductionmentioning

confidence: 99%

An Environmentally Friendly Process for the Preparation of 16‐Dehydropregnenolone Acetate

Zhang

Liu

Xue-Xin³

et al. 2005

Chin. J. Chem.

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Instead of environmentally toxic chromium oxidant, singlet oxygen generated photochemically was used as environmentally friendly and benign oxidizing agent to accomplish the transformation of pseudodiosgenin diacetate to diosone efficiently in a low toxic and less expensive solvent acetone. Accordingly 16-dehydropregnenolone acetate (16-DPA), an important intermediate for preparation of steroidal drugs, was prepared in good yield (75%) when photoreaction was run in acetone/acetic anhydride/pyridine system. The mild reaction condition as well as simple and environmentally friendly process made the method commercially viable and important for production of 16-DPA in industrial scale.

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“…Citrate a t high concentrations (12 mM) inhibited the enzyme (7). Ethacrynic acid was reported to be one-half as potent as theophylline against the enzyme from beef heart (8). Recently, acidic anti-inflammatory agents were reported to inhibit phosphodiesterase (9-1 1).…”

mentioning

confidence: 99%

“…at 175" was used instead. Monoglucoside and maltoside of 25(R)-spirost-5-en-3P-ol(II) were prepared by known methods (8).…”

mentioning

confidence: 99%

Cytotoxic Saponins from the Chinese Herbal Drug Yunnan Bai Yao

Ravikumar

Hammesfahr

Sih

1979

Journal of Pharmaceutical Sciences

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Sterols. CXII. Sapogenins. XLI. The Preparation of Trillin and its Conversion to Progesterone

Cited by 48 publications

References 0 publications

Phytochemistry, Anthelmintic study of herbaceous aerial part of Kallstroemia pubescens (G. Don) & Review of Novel Effects of Diosgenin: A Plant Derived Steroid

Phytochemistry, Anthelmintic study of herbaceous aerial part of Kallstroemia pubescens (G. Don) & Review of Novel Effects of Diosgenin: A Plant Derived Steroid

An Environmentally Friendly Process for the Preparation of 16‐Dehydropregnenolone Acetate

Cytotoxic Saponins from the Chinese Herbal Drug Yunnan Bai Yao

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