Sterol‐standardized phytopharmaceutical from ground cherry: Corticoid‐like properties on human keratinocytes and fibroblasts and its effects in a randomized double‐blind placebo‐controlled clinical trial

Abstract

Background: Topical corticosteroids have been the most commonly prescribed drugs to treat skin inflammation, but their uses can lead to several adverse effects. Nowadays, new pharmacological strategies have been evaluated to improve dermatologic efficacy and reduce adverse effects, including natural products. Objectives:The aim of this study was to evaluate and compare the effects of a plant sterol standardized supercritical CO 2 phytopharmaceutical of Physalis angulata L. with hydrocortisone on the immune and inflammatory mediators, and skin repair components production. Moreover, we studied effects of both products on the skin microcirculation and temperature in a double-blind placebo-controlled clinical trial.Methods: Both products were evaluated on the immune (IL-6, IL-10, INF-γ, TNF-α, and IL-1α), inflammatory (COX-2, LOX, PLA 2 , PGE 2 , LTB 4 , histamine, and NF-κB), and repair components (TGF-β, GM-CSF, collagen, and GAG) production on human keratinocytes and fibroblast in non-stimulated and LPS-stimulated conditions. Indeed, in a randomized double-blind placebo-controlled clinical trial, we evaluated the effects of the both creams on the skin microcirculation and temperature using laser Doppler and infrared thermometer, respectively. Results:Physalis angulata acted on the skin, modulating immune status and inflammatory response producing corticoid-like effects, but different of hydrocortisone, increased skin repair factors. The effects of phytopharmaceutical cream in the clinical trial promoted a better reduction in skin microcirculation and temperature than hydrocortisone.Conclusions: Taken together, the results indicate that sterol standardized CO 2 supercritical preparation of P angulata is a new and innovative phytopharmaceutical with multiple pharmacological effects potentially useful as human skin protective product, particularly against cutaneous inflammatory disorders.

Effect of Physalis angulata leaf extract cream on Interleukin-4, Interleukin-6, and Immunoglobulin-E in mice with induced atopic dermatitis

“…Topically applied Physalis angulata is also reported as a new and innovative phytopharmaceutical with various pharmacological effects that are potentially useful to protect human skin, especially against inflammation. (14) Another study also showed that PA cream containing physalin-E conferred benefits as an anti-inflammatory agent in acute and chronic dermatitis in experimental animals, which has therapeutic potential for the chronic and recurrent inflammatory disease AD. (15) Our study might give suggestions about whether Physalis angulata is a potential antiinflammatory drug.…”