Steroids: reactions and partial synthesis (1999)

Hanson, James R.

doi:10.1039/b009026n

Cited by 7 publications

(3 citation statements)

References 99 publications

(101 reference statements)

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“…The infrared spectra of the solid chromyl acetate in a KBr pellet and in d 6 -DMSO solutions were taken from a previous study where the compound was obtained as reported in Ref. [24] and from our measurements [8].…”

Section: Vibrational Studymentioning

confidence: 99%

“…In organic chemistry, for a long time the chemical reactivity of chromyl acetate, CrO 2 (CH 3 COO) 2 was broadly studied because it is an effective reagent for the oxidation of numerous compounds, such as hydrocarbons [1,2], olefins [3,4], C-25 on cholestane side-chains to the corresponding C-25 hydroxy derivative [5], steroids [6] and indole alkaloids [7] among others, but so far their molecular structure is unknown. In a previous paper we could assign some of the observed bands in the infrared spectrum and for this their vibrational properties remain only partially characterized [8].…”

Section: Introductionmentioning

confidence: 99%

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Structural and Vibrational Study on Chromyl Acetate in Different Media

Brandán

2012

SpringerBriefs in Molecular Science

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In this chapter, the structural and vibrational properties of chromyl acetate in different media were studied using density functional theory (DFT) methods. The initial geometries were fully optimized at different theory levels and the harmonic wavenumbers were evaluated at the same levels. Also, the characteristics and nature of the Cr-O and Cr / O bonds for the stable structure were studied by means of the natural bond orbital (NBO) study while the topological properties of the electronic charge density were analyzed using the Bader atoms in the molecules theory (AIM). Besides, a complete assignment of all observed bands in the infrared spectrum for the compound was performed combining DFT calculations with Pulay 0 s scaled quantum mechanics force field (SQMFF) methodology.

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Section: Vibrational Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural and Vibrational Study on Chromyl Acetate in Different Media

Brandán

2012

SpringerBriefs in Molecular Science

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“…The desirability of applying combinatorial chemistry to the synthesis of libraries of steroidal derivatives is obvious. Steroids represent a broad class of natural products playing crucial roles in the homeostasis of biological systems. − Numerous existing drugs are, thus, steroidal derivatives exerting a wide variety of actions: receptor agonists or antagonists of estrogens, androgens, progestins and corticoids and inhibitors of steroidogenic enzymes. Recent advances in the area of signal transduction mediated by steroid receptors, particularly for selective modulators of estrogen and androgen receptors, make combinatorial synthesis of steroid derivatives an even more attractive approach for the development of new drugs acting on hormone-related diseases, such as cancers and osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Steroids and Combinatorial Chemistry

et al. 2004

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Fundamentals of Steroid Chemistry and Biochemistry

Brueggemeier¹,

Li²

2003

Burger's Medicinal Chemistry and Drug Discovery

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Steroids are a unique class of chemical compounds found throughout the animal and plant kingdom. This class includes sterols such as cholesterol and ergosterol, bile acids, and steroid hormones. Chemical research on steroids began with isolation and structure determination, and major research efforts focused on total synthesis and on the development of numerous reactions for modifying the steroid scaffold. Methods in microbial transformations of steroids were developed to produce large quantities of steroid starting materials at reduced costs. Research in steroid biochemistry first began with studies on the biosynthesis and metabolism of steroids, followed soon thereafter by investigations on the biochemical mechanism of action of steroids. Over the past several decades, steroid biochemistry and molecular biology have focused on steroidogenic enzymes, nuclear steroid receptors, and gene expression. The discovery of the anti‐inflammatory effects of cortisone in the treatment of rheumatoid arthritis and the report of the contraceptive effects of estrogen and progestin preparations illustrated for the first time that steroids could be considered as medicinal agents. As a result, extensive research on the medicinal chemistry, pharmacology, and clinical studies of steroid agonists and antagonists has evolved and continues to provide new insights and new medicinal agents for therapies in many different diseases and chemoprevention strategies.

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Steroids: reactions and partial synthesis (1999)

Cited by 7 publications

References 99 publications

Structural and Vibrational Study on Chromyl Acetate in Different Media

Structural and Vibrational Study on Chromyl Acetate in Different Media

Steroids and Combinatorial Chemistry

Fundamentals of Steroid Chemistry and Biochemistry

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