Steroidogenesis in the fungus Pleurotus ostreatus

Plemenitaš, Ana; Kastelic-Suhadolc, T.; Žigon, Dušan; Žakelj-Mavrič, Marija

doi:10.1016/s0305-0491(99)00053-x

Cited by 9 publications

(3 citation statements)

References 14 publications

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“…The reasons for these sexual differences are indistinct. Previous reports show that some fungal species possess steroidogenic activity and substrates, mainly testosterone or androstendione, in their mycelium 3,5 . Additionally, a steroidogenic enzyme 17β‐hydroxysteroid dehydrogenase (17β‐HSD), has been identified in the cytosol of the mycelium of Rhizopus nigricans 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Recent data have suggested that vertebrate hormonal signal transduction mechanisms might have originated in early eukaryotes 1,2 . Previous papers have revealed endogenous steroidogenesis and the identification of a steroidal substrate in many fungal species 3–5 . Rhizopus is a filamentous fungi belonging to the family Mucoraceae of group Thallophyta, and is widely used for the produc‐tion of pharmacologically active steroids through steroid hydroxylation 6 .…”

Section: Introductionmentioning

confidence: 99%

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Effects of Rhizopus extract administration on somatic growth and sexual maturation in lacustrine sockeye salmon Oncorhynchus nerka

Bhandari

Ushikoshi²,

Fukuoka

et al. 2002

Fisheries Sci

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The filamentous fungi Rhizopus, like many fungal species, possesses physiologically active substances. Rhizopus extract (RU) is reported to be effective for various aspects of growth and reproduction in many vertebrates. The effects of RU administration on body growth and plasma levels of steroid hormones were investigated in lacustrine sockeye salmon Oncorhynchus nerka. One‐year‐old fish were fed daily with RU (20 mg/kg feed) from July 1999 to October 2000 for 15 months. Fish were sampled every month and plasma levels of testosterone (T), 11‐ketotestosterone (11‐KT), estradiol‐17β (E2) and 17α,20β‐dihydroxy‐4‐pregnen‐3‐one (DHP) were measured by time‐resolved fluoroimmunoassay. Body growth of RU‐fed fish of both sexes increased significantly in 1+ and 2+ October, and 2+ January–March and July. All RU‐fed males and one female matured in 2+ October. RU‐fed 1+ precociously mature males showed increased plasma levels of T, 11‐KT and DHP in 1+ October. In 2+ males, RU significantly elevated plasma levels of T from May to June, 11‐KT from June to July, and DHP in October. In sockeye salmon, administration of RU accelerated body growth of both sexes and sexual maturation in males, suggesting physiologically active substances present in RU enhance somatic growth and sexual maturation by sex‐specific mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Rhizopus extract administration on somatic growth and sexual maturation in lacustrine sockeye salmon Oncorhynchus nerka

Bhandari

Ushikoshi²,

Fukuoka

et al. 2002

Fisheries Sci

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“…It has been suggested that the vertebrate hormonal signal transduction mechanisms may have their origins in early eukaryotes (Janssens 1987; Pertseva 1991). Consecutively, the presence of mammalian‐like peptide and steroid hormones, steroid enzymes and protein receptors in the mycelium of several fungus species has been reported (Kastelic‐Suhadolc, Plemenitaš & Žigon 1994; Plementiaš, Kastelic‐Suhadolc, Žigon & Žakelj‐Mavrič 1999; Lanišnik & Žakelj‐Mavrič 2000). These findings, mainly endogenous steroidogenesis and characterization of the bioactive substances in the cytosols of the fungi tested so far, may indicate the possibility of other fungal species possessing similar properties in their mycelium (Pogačar, Zorko & Žakelj‐Mavrič 1998; Kristan, Lanišnik, Stojan, Gerber, Kremmer & Adamski 2003).…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro effects of Rhizopus extract on body growth and steroid production in masu salmon, Oncorhynchus masou Brevoort

Mingist

Ushikoshi²,

Ueda

2007

Aquaculture Res

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This study investigated in vivo and in vitro effects of Rhizopus (filamentous fungus) extract (RU) in masu salmon Oncorhynchus masou Brevoort. Underyearling fish were fed with RU for 16 months. Monthly changes in body growth, gonadal maturation and serum levels of sex steroids were monitored. Gonads were also incubated at 0, 1, 10, 100 and 1000 µg RU mL − 1 Leibovitz's L-15 medium for 18 h. Levels of steroids in serum and cultured medium were measured. It was determined that RU-fed immature and mature males, when compared to control groups, showed significantly higher body growth during spring, summer, and the spawning period. Similarly, immature RU-fed females showed significantly higher fork length and body weight in autumn, spring and summer. Furthermore, RU-fed males showed significantly higher levels of serum testosterone (T) and 11-ketotestosterone (11-KT) levels in pre-spawning season, and 17α,20β-dihydroxy-4-pregnen-3-one (DHP) in spawning season. In vitro RU incubation of gonads showed a dose-dependent and significant increase in T, 11-KT, estradiol-17βand DHP release in the medium. It appears that the causes of enhanced body growth and increased steroid production herein observed in salmonids are the physiologically active substances that may be contained in the mycelium of the fungus.

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Hormone signaling in evolution and development: a non-model system approachs

2004

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Cooption and modularity are informative concepts in evolutionary developmental biology. Genes function within complex networks that act as modules in development. These modules can then be coopted in various functional and evolutionary contexts. Hormonal signaling, the main focus of this review, has a modular character. By regulating the activities of genes, proteins and other cellular molecules, a hormonal signal can have major effects on physiological and ontogenetic processes within and across tissues over a wide spatial and temporal scale. Because of this property, we argue that hormones are frequently involved in the coordination of life history transitions (LHTs) and their evolution (LHE). Finally, we promote the usefulness of a comparative, non-model system approach towards understanding how hormones function and guide development and evolution, highlighting thyroid hormone function in echinoids as an example.

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Steroidogenesis in the fungus Pleurotus ostreatus

Cited by 9 publications

References 14 publications

Effects of Rhizopus extract administration on somatic growth and sexual maturation in lacustrine sockeye salmon Oncorhynchus nerka

Effects of Rhizopus extract administration on somatic growth and sexual maturation in lacustrine sockeye salmon Oncorhynchus nerka

In vivo and in vitro effects of Rhizopus extract on body growth and steroid production in masu salmon, Oncorhynchus masou Brevoort

Hormone signaling in evolution and development: a non-model system approachs

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