Steroidogenesis—Adrenal Cell Signal Transduction

Gallo‐Payet, Nicole; Battista, Marie-Claude

doi:10.1002/cphy.c130050

Cited by 59 publications

(46 citation statements)

References 758 publications

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“…B 282: 20152080 types (i.e. steroidogenic versus non-steroidogenic) to establish the precise role of these cells in steroid metabolism (reviewed in [35]; but see [43]). We tested the role of melatonin independent of photoperiod-induced changes in reproductive physiology on aggression, and our data strongly support the idea that melatonin drives seasonal changes in DHEA synthesis and aggression.…”

Section: Discussionmentioning

confidence: 99%

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

et al. 2015

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Classic findings have demonstrated an important role for sex steroids as regulators of aggression, but this relationship is lacking within some environmental contexts. In mammals and birds, the adrenal androgen dehydroepiandrosterone (DHEA), a non-gonadal precursor of biologically active steroids, has been linked to aggression. Although females, like males, use aggression when competing for limited resources, the mechanisms underlying female aggression remain understudied. Here, we propose a previously undescribed endocrine mechanism regulating female aggression via direct action of the pineal hormone melatonin on adrenal androgens. We examined this in a solitary hamster species, Phodopus sungorus, in which both sexes are highly territorial across the seasons, and display increased aggression concomitant with decreased serum levels of sex steroids in short 'winter-like' days. Short-but not long-day females had increased adrenal DHEA responsiveness co-occurring with morphological changes in the adrenal gland. Further, serum DHEA and total adrenal DHEA content were elevated in short days. Lastly, melatonin increased DHEA and aggression and stimulated DHEA release from cultured adrenals. Collectively, these findings demonstrate that DHEA is a key peripheral regulator of aggression and that melatonin coordinates a 'seasonal switch' from gonadal to adrenal regulation of aggression by direct action on the adrenal glands.

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Section: Discussionmentioning

confidence: 99%

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

et al. 2015

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“…The main stimuli responsible for modulating zG size are AngII and plasma K + levels (Gallo-Payet and Battista, 2014). AngII is an octapeptide, derived from serial proteolytic cleavage of angiotensinogen and Angiotensin I, which acutely regulates blood pressure through direct effects on vascular tone.…”

Section: Signaling Pathways and Zonationmentioning

confidence: 99%

“…It is composed of concentric zones of steroidogenic cells surrounding the chromaffin cells of the adrenal medulla (Gallo-Payet and Battista, 2014; Yates et al, 2013). Each zone of the cortex produces distinct steroid hormones that affect a variety of physiological functions.…”

Section: Introductionmentioning

confidence: 99%

“…Proper control of steroidogenic function in the adult adrenal cortex relies not only on appropriate endocrine signaling but also on the integrity of tissue structure and homeostasis (Gallo-Payet and Battista, 2014). Disruption of zonation and homeostasis has been implicated in many adrenal diseases such as primary aldosteronism, cortisol-producing adenomas, primary pigmented nodular adrenocortical disease (PPNAD), congenital adrenal hyper- and hypoplasia and adrenocortical carcinoma (Walczak and Hammer, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Regulation of zonation and homeostasis in the adrenal cortex

Pignatti

Leng

Carlone

et al. 2017

Molecular and Cellular Endocrinology

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The adult adrenal cortex is organized into concentric zones, each specialized to produce distinct steroid hormones. Cellular composition of the cortex is highly dynamic and subject to diverse signaling controls. Cortical homeostasis and regeneration rely on centripetal migration of steroidogenic cells from the outer to the inner cortex, which is accompanied by direct conversion of zona glomerulosa (zG) into zona fasciculata (zF) cells. Given the important impact of tissue structure and growth on steroidogenic function, it is essential to understand the mechanisms governing adrenal zonation and homeostasis. Towards this end, we review the distinctions between each zone by highlighting their morphological and ultra-structural features, discuss key signaling pathways influencing zonal identity, and evaluate current evidence for long-term self-renewing stem cells in the adult cortex. Finally, we review data supporting zG-to-zF transdifferentiation/direct conversion as a major mechanism of adult cortical renewal.

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“…The regulation of steroidogenesis is predominantly controlled by pituitary-synthesized trophic hormones, the luteinizing (LH) (Dufau, 1998), the follicule-stimulating (FSH) and adrenocorticotropin hormones (ACTH), angiotensin II (Ang II) (Gallo-Payet and Battista, 2014;Manna and Stocco, 2005) and many other factors, such as cytokines (Bornstein et al, 2004;Haidan et al, 2000) and growth factors (Manna and Stocco, 2005). Normal function of both ovary and testis is long recognized to be dependent on LH and FSH.…”

Section: Introductionmentioning

confidence: 99%