Steroidal Saponins from Tribulus terrestris

Tribulus terrestris is a valuable herb known for its application in the folk medicine in many parts of the world. Furostanol and spirostanol saponins of tigogenin, neotigogenin, gitogenin, neogitogenin, hecogenin, neohecogenin, diosgenin, chlorogenin, ruscogenin and sarsasapogenin type are frequently found in this plant. Four sulphated saponins of tigogenin and diosgenin type are also isolated. Extracts and steroidal saponins have been found to possess various pharmacological activities. Preparations based on the saponin fraction of T. terrestris are used for treatment of infertility and libido disorders in men and women, as well as for treatment of cardiac diseases. Food supplements containing T. terrestris extracts are on sale in USA and Europe with claim of a general stimulating action.

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“…Repeated CC on silica gel and HPLC are frequently used for separation of saponins in crude saponin fractions (Cai et al, 2001;Xu et al, 2001).…”

Section: Isolation Of Saponinsmentioning

confidence: 98%

“…Both the spirostanol and furostanol saponins give yellow spots on thin layer chromatography (TLC) with anisaldehyde reagent, but only the furostanol saponins furnish a red colour with Ehrlich's reagent (Cai et al, 2001).…”

Section: Isolation Of Saponinsmentioning

confidence: 99%

Saponins in Tribulus terrestris – Chemistry and Bioactivity

2005

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“…Numerous research studies report on its effectiveness in male and female libido disorders, impotence, infertility, and sperm motility. Some studies focus on its cardiovascular, cytotoxic, and antimicrobial activities [5][6][7]. The occurrence of saponins, flavonoids, alkaloids, lignanamides, and cinammic acid amides in T. terrestris has been described [8,9].…”

Section: Introductionmentioning

confidence: 99%

Response Surface Optimization of Essential Oil and Diosgenin Extraction from Tribulus terrestris via Supercritical Fluid Technology

2011

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Four operating parameters of supercritical carbon dioxide extraction were optimized by the response surface method. The central composite rotatable design was used to maximize extraction recovery of essential oil (specifically diosgenin) from Tribulus terrestris. The obtained data were adequately fitted into two second-order polynomial models for essential oil and diosgenin. The linear terms of pressure, temperature, and extraction dynamic time, the quadratics of pressure and extraction dynamic time, and the interactions of the following two variables: (i) pressure and temperature, (ii) pressure and extraction dynamic time, and (iii) temperature and extraction dynamic time had significant effects on diosgenin recovery.

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“…the clinical trials show that the saponins of T. terrestris possess coronary artery dilation effect, improve coronary circulation, and act as antihypertensive and vasodilator agents. they are recommended for treatment of angina pectoris and other cardiovascular diseases, including hypertension and atherosclerosis (9,27,43,46,48,51,58,62).…”

Section: Complex Investigations Of Tribulus Terrestris L For Sustainmentioning

confidence: 99%