Steroidal oxazoles, oxazolines, and oxazolidines

Abstract

In recent years the interest of this investigator has been attracted to a series of new compounds in which a cyclopentanoperhydrophenanthrene system is condensed with various heterocyclic rings. As was to be expected, the addition of heterocycles to steroids often leads to a change of their physiological activity and the appearance of new interesting biological properties. Since the numerous data on the synthesis and properties of the steroidal oxazoles, oxazolines, and oxazolidines are scattered, this stimulated us to write the present review, in which the literature published up to the end of 1994 is systematized.

1,1'‐Bis(oxazolin‐2‐yl)ferrocenes: An Investigation of Their Complexation Behavior toward [Pd(η3‐allyl)Cl]2

“…Oxazolines are an intensively studied class of compounds. These five-membered heterocycles are found in natural metal chelators, [1][2][3] show interesting biological properties, [4,5] and also play an important role in synthesis [6][7][8][9][10] as well as have a remarkable range of applicability. Their uses vary widely from organic [6][7][8] and coordination chemistry, [9,10] via polymer chemistry, [11][12][13] to antiacaricide as well as antiinsecticidic purposes.…”

Recent syntheses of steroidal oxazoles, oxazolines and oxazolidines

“…To the best of our knowledge and much to our surprise, there are no reports on this subject since 1996. 23…”

6,11-Bisthia Steroidal Analogues: Synthesis, Characterization, and Evaluation of Antimicrobial-, Antituberculosis-, and Antitumor Activity

“…The general process of drug discovery has been the phenotypic observations of the impact of a naturally occurring compound or a synthesized one on its bioactivity. An extensive focus of research has been directed recently towards modified steroids bearing heterocycles fused to the A-or D-ring of the steroid nucleus [1][2][3][4][5]. Several types of steroidal [3,2-c]pyrazoles, such as androst-4-eno-and androstano [3,2-c]pyrazoles [6], 5α-pregnano-and pregn-4eno [3,2-c]pyrazoles [7] were synthesized by formylation at the 2-position followed by the reaction of the resulting 2-hydroxymethylene-3-ketosteroids with hydrazines.…”